WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
any high mountain

PrepTutorEJDIC

アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
高山,高峰

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/02 14:36:08」(JST)

wiki en

alpha-Naphthoflavone, also known as 7,8-benzoflavone and 2-phenyl-benzo(h)chromen-4-one, is a synthetic^[1]^[2] flavone derivative. It can be prepared from 2-naphthol and cinnamaldehyde.^[3]

alpha-Naphthoflavone is a potent inhibitor of the enzyme aromatase, the enzyme that converts testosterone to estrogen.^[1]^[2] alpha-Naphthoflavone has been shown to cause abnormal testicular development in young chickens.^[4]

References

^ ^a ^b Campbell, Deborah R.; Kurzer, Mindy S. (1993). "Flavonoid inhibition of aromatase enzyme activity in human preadipocytes". Journal of Steroid Biochemistry and Molecular Biology. 46 (3): 381–388. doi:10.1016/0960-0760(93)90228-O. PMID 9831487.
^ ^a ^b Kellis JT Jr; Vickery LE (1984). "Inhibition of human estrogen synthetase (aromatase) by flavones". Science. 225 (4666): 1032–1034. doi:10.1126/science.6474163. PMID 6474163.
^ Harvey, Ronald G.; Hahn, Jung Tai; Bukowska, Maria; Jackson, Henry (1990). "A new chromone and flavone synthesis and its utilization for the synthesis of potentially antitumorigenic polycyclic chromones and flavones". The Journal of Organic Chemistry. 55 (25): 6161. doi:10.1021/jo00312a023.
^ Trefil, P.; Micakova, A.; Stiborova, M.; Poplstein, M.; Brillard, J.P.; Hodek, P. (2004). "Effects of alpha-naphthoflavone on body growth and gonad development in chickens (Gallus domesticus)". Czech Journal of Animal Science - UZPI. 49 (6): 231–238.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. α-1アンチトリプシン欠乏の治療 treatment of alpha 1 antitrypsin deficiency
2. ステロイド5 -α-レダクターゼ2欠乏症 steroid 5 alpha reductase 2 deficiency
3. αサラセミアの病態生理 pathophysiology of alpha thalassemia
4. 原発性肝細胞癌の臨床的特徴および診断 clinical features and diagnosis of primary hepatocellular carcinoma
5. α-1アンチトリプシン欠乏症の臨床症状、診断、および自然経過 clinical manifestations diagnosis and natural history of alpha 1 antitrypsin deficiency

English Journal

Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent.

Flores-Pérez A1, Elizondo G2.
Chemico-biological interactions.Chem Biol Interact.2018 Feb 1;281:98-105. doi: 10.1016/j.cbi.2017.12.029. Epub 2017 Dec 20.
PMID 29274324

The synthesis of chalcones as anticancer prodrugs and their bioactivation in CYP1 expressing breast cancer cells.

Ruparelia KC1, Zeka K1, Ijaz T1, Ankrett DN1, Wilsher NE1, Butler PC1, Tan HL1, Lodhi S1, Bhambra AS1, Potter GAPRRA1, Arroo RR1, Beresford KJM1.
Medicinal chemistry (Shariqah (United Arab Emirates)).Med Chem.2018 Jan 12. doi: 10.2174/1573406414666180112120134. [Epub ahead of print]
PMID 29332599

Resveratrol supports and alpha-naphthoflavone disrupts growth of human ovarian follicles in an in vitro tissue culture model.

Hao J1, Tuck AR2, Sjödin MOD2, Lindberg J2, Sand A3, Niklasson B4, Argyraki M4, Hovatta O4, Damdimopoulou P5.
Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2018 Jan 1;338:73-82. doi: 10.1016/j.taap.2017.11.009. Epub 2017 Nov 14.
PMID 29146461

Japanese Journal

Induction of cytochrome P-450 1A1 by omeprazole in human HepG2 cells is protein tyrosine kinase-dependent and is not inhibited by alpha-naphthoflavone

KIKUCHI H.
Arch Biochem Biophys 358, 351-358, 1998
NAID 80010639815

Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells

MERCHANT M
Toxicol Appl Pharmacol 120, 179-185, 1993
NAID 30022974812

Related Pictures

Anna V. Gubskaya's Homepage alpha-Naphthoflavone products,China alpha-Naphthoflavone supplier alpha-Naphthoflavone, 99.5%, ACROS Organics™ 1g; Glass bottle alpha-Naphthoflavone α-Naphthoflavone, CAS 604-59-1 | SCBT - Santa Cruz Biotechnology α-NF suppresses 3T3-L1 pre-adipocyte differentiation. Differentiation | Download Alfa Aesar™ alpha-Naphthoflavone, 97%: Other Organics A-Z Chemikalien 北京上草生物科技有限公司官网（www.china-api.cn; www.leaderherb.com

★リンクテーブル★

リンク元	「αナフトフラボン」「α-ナフトフラボン」
関連記事	「alpha」

「αナフトフラボン」

*alpha*-Naphthoflavone
Names
	IUPAC name 2-phenylbenzo[h]chromen-4-one
	Other names 7,8-Benzoflavone, ANF,2-phenylbenzo[h]chromen-4-one
Identifiers
CAS Number	604-59-1 ;
3D model (Jmol)	Interactive image;
ChEBI	CHEBI:76995 ;
ChemSpider	11297 ;
DrugBank	DB07453 ;
ECHA InfoCard	100.009.156
	InChI InChI=1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H Key: VFMMPHCGEFXGIP-UHFFFAOYSA-N ; InChI=1/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H Key: VFMMPHCGEFXGIP-UHFFFAOYAW ;
	SMILES O=C\1c4c(O/C(=C/1)c2ccccc2)c3ccccc3cc4 ;
Properties
Chemical formula	C19H12O2
Molar mass	272.30 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references