アラニン脱水素酵素
WordNet
- a crystalline amino acid that occurs in many proteins
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/05/07 23:38:05」(JST)
[Wiki en表示]
alanine dehydrogenase |
Identifiers |
EC number |
1.4.1.1 |
CAS number |
9029-06-5 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
|
Alanine dehydrogenase (EC 1.4.1.1) is an enzyme that catalyzes the chemical reaction
- L-alanine + H2O + NAD+ pyruvate + NH3 + NADH + H+
The 3 substrates of this enzyme are L-alanine, water, and nicotinamide adenine dinucleotide+, whereas its 4 products are pyruvate, ammonia, NADH, and hydrogen ion.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-alanine:NAD+ oxidoreductase (deaminating). Other names in common use include AlaDH, L-alanine dehydrogenase, NAD+-linked alanine dehydrogenase, alpha-alanine dehydrogenase, NAD+-dependent alanine dehydrogenase, alanine oxidoreductase, and NADH-dependent alanine dehydrogenase. This enzyme participates in taurine and hypotaurine metabolism and reductive carboxylate cycle (CO2 fixation).
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1OMO, 1PJB, 1PJC, 1SAY, 1VLL, and 2EEZ.
References
- O'Connor RJ and Halvorson H (1961). "The substrate specificity of L-alanine dehydrogenase". Biochim. Biophys. Acta 48 (1): 47–55. doi:10.1016/0006-3002(61)90513-3. PMID 13730044.
- Pierard A and Wiame JM (1960). "Proprietes de la L(+)-alanine-deshydrogenase". Biochim. Biophys. Acta 37 (3): 490–502. doi:10.1016/0006-3002(60)90506-0.
- Yoshida A and Freese E (1965). "Enzymic properties of alanine dehydrogenase of Bacillus subtilis". Biochim. Biophys. Acta 96: 248–262. PMID 14298830.
UpToDate Contents
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English Journal
- Protective effects of Cholestin on ethanol induced oxidative stress in rats.
- Hsieh YL1, Yeh YH, Lee YT, Huang CY.
- Journal of the science of food and agriculture.J Sci Food Agric.2015 Mar 15;95(4):799-808. doi: 10.1002/jsfa.6904. Epub 2014 Oct 14.
- BACKGROUND: Male Wistar rats were divided into seven groups as follows: group A, basal diet; group B, basal diet with Cholestin at 0.1667 g kg(-1) body weight (BW); groups C-F, oral feeding of ethanol at 7.9 g kg(-1) BW; groups D-F, Cholestin in diet at 0.1667, 0.3333 and 0.5 g kg(-1) BW
- PMID 25200286
- Design and development of novel Mycobacterium tuberculosisl-alanine dehydrogenase inhibitors.
- Saxena S1, Samala G1, Sridevi JP1, Devi PB1, Yogeeswari P1, Sriram D2.
- European journal of medicinal chemistry.Eur J Med Chem.2015 Mar 6;92:401-14. doi: 10.1016/j.ejmech.2014.12.046. Epub 2014 Dec 27.
- In the present study, we used crystal structure of MTB L-AlaDH protein complex with N6-methyl adenosine for structure based virtual screening of in house database to identify new small molecule inhibitors for MTB-L-AlaDH. Two molecules identified as better leads and were modified synthetically to ob
- PMID 25585006
- Desalting large protein complexes during native electrospray mass spectrometry by addition of amino acids to the working solution.
- Clarke DJ1, Campopiano DJ.
- The Analyst.Analyst.2015 Mar 2. [Epub ahead of print]
- Native mass spectrometry is a rapidly emerging field for characterising the structure of proteins and protein assemblies. The technique relies on electrospray ionisation (ESI) to efficiently ionise the protein analyte and transmit it into the gas phase with retention of protein structure, non-covale
- PMID 25729779
Japanese Journal
- Blood levels related to the Z-score of bone mineral density in young males and females
- Joo Sun-Hyung,Kim Min-Tae,Cho Jae-Hwan,Lee Hae-Kag,Ahn Jae-Ouk
- Journal of Physical Therapy Science 27(4), 1117-1120, 2015
- … [Results] The results showed a correlation of 0.212 for total protein, −0.317 for alanine aminotransferase, −0.199 for gamma-glutamyl transferase, −0.358 for alkaline phosphatase, 0.266 for uric acid, −0.313 for lactate dehydrogenase, 0.244 for creatinine, −0.234 for the red blood cell count, and −0.230 for the red cell distribution width in patients with less than expected level for their age. …
- NAID 130005067517
- 汎用性殺虫剤を投与したウィスター系雄ラットにおける血漿,赤血球膜結合酵素および細胞組織の変化
- Nwozo Sarah,Akpodono Enor,Oyinloye Babatunji
- Journal of Pesticide Science advpub(0), 2015
- … Glucose-6-phosphate dehydrogenase (G6PD), glutathione-S-transferase (GST), acetylcholine (ACH), and body weight decreased significantly in DDVP- and LMB-treated rats only. … Plasma urea and creatinine were insignificant, while aspartate aminotransferase (AST) and alanine amino transferase (ALT) increased significantly in DDVP only; …
- NAID 130004939773
- 汎用殺虫剤を投与したウィスター系雄ラットにおける血漿,赤血球膜結合酵素および細胞組織の変化
- Nwozo Sarah,Akpodono Enor,Oyinloye Babatunji
- Journal of Pesticide Science 40(1), 13-18, 2015
- … Glucose-6-phosphate dehydrogenase (G6PD), glutathione-S-transferase (GST), acetylcholine (ACH), and body weight decreased significantly in DDVP- and LMB-treated rats only. … Plasma urea and creatinine were insignificant, while aspartate aminotransferase (AST) and alanine amino transferase (ALT) increased significantly in DDVP only; …
- NAID 130004939752
Related Links
- Catalyzes the reversible reductive amination of pyruvate to L-alanine. This enzyme is a key factor in the assimilation of L-alanine as an energy source through ... « Hide 10 20 30 40 50 MLIGVPKEIK ...
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★リンクテーブル★
[★]
アラニン
- 関
- A、Ala、alanyl、L-alanine
[★]
脱水素酵素 デヒドロゲナーゼ
[★]
脱水素酵素 デヒドロゲナーゼ