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Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms.

Carr R 3rd1, Koziol-White C1, Zhang J1, Lam H1, An SS1, Tall GG1, Panettieri RA Jr1, Benovic JL2.
Molecular pharmacology.Mol Pharmacol.2016 Jan;89(1):94-104. doi: 10.1124/mol.115.100339. Epub 2015 Oct 13.
Gαqβγ heterotrimer (Gq), an important mediator in the pathology of airway disease, plays a central role in bronchoconstriction and airway remodeling, including airway smooth muscle growth and inflammation. Current therapeutic strategies to treat airway disease include the use of muscarinic and le
PMID 26464325

The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma.

Kwak HJ1, Park DW1, Seo JY1, Moon JY1, Kim TH1, Sohn JW1, Shin DH1, Yoon HJ1, Park SS1, Kim SH1.
Experimental & molecular medicine.Exp Mol Med.2015 Dec 11;47:e198. doi: 10.1038/emm.2015.91.
Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is available. The Wnt/β-catenin signaling pathway is involved in various physiological
PMID 26655831

Temporal and Spatial Expression of TGF-β Following Airway Remodeling to Tobacco Smoke in Rats.

Hoang LL1, Nguyen YP2, Aspeé R3, Bolton SJ4, Shen YH5, Wang L6, Kenyon NJ7, Smiley-Jewell S8, Pinkerton KE9.
American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2015 Dec 4. [Epub ahead of print]
Airway remodeling is strongly correlated with the progression of chronic obstructive pulmonary disease (COPD). In this study, our goal is to characterize progressive structural changes in site-specific airways, along with the temporal and spatial expression of transforming growth factor-β (TGF-β)
PMID 26637070

Matsuse Hiroto,Kohno Shigeru
Expert Opinion on Pharmacotherapy 15(3), 353-363, 2014-02
… Introduction: The prevalence of bronchial asthma, which is a chronic inflammatory disorder of the airway, is increasing worldwide. … Several issues such as predicted responses, effects of peripheral airway and airway remodeling and alternative administration routes remain to be clarified before LTRAs could serve a more effective role in the treatment of asthma. …
NAID 120005394591

Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids.

Kanemitsu Yoshihiro,Matsumoto Hisako,Izuhara Kenji,Tohda Yuji,Kita Hideo,Horiguchi Takahiko,Kuwabara Kazunobu,Tomii Keisuke,Otsuka Kojiro,Fujimura Masaki,Ohkura Noriyuki,Tomita Katsuyuki,Yokoyama Akihito,Ohnishi Hiroshi,Nakano Yasutaka,Oguma Tetsuya,Hozawa Soichiro,Nagasaki Tadao,Ito Isao,Oguma Tsuyoshi,Inoue Hideki,Tajiri Tomoko,Iwata Toshiyuki,Izuhara Yumi,Ono Junya,Ohta Shoichiro,Tamari Mayumi,Hirota Tomomitsu,Yokoyama Tetsuji,Niimi Akio,Mishima Michiaki
The Journal of allergy and clinical immunology 132(2), 305-312.e3, 2013-08
… [Background]Periostin, an extracellular matrix protein, contributes to subepithelial thickening in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. … However, the relationship between periostin and the development of airflow limitation, a functional consequence of airway remodeling, remains unknown. …
NAID 120005342661

リンク元	「気道壁リモデリング」
関連記事	「airway」