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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/10 23:58:35」(JST)

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Adipsia is a condition that can affect both humans and other animals^[1] and involves an absence of thirst.^[2] Its underlying causes vary but have included anomalies involving the hypothalamus, pituitary and corpus collosum.^[3] Although Diabetes insipidus usually involves polydipsia, it can also rarely occur not just in the absence of polydipsia but in the presence of such diminished thirst as to fit hypodipsia or adipsia. While adipsia is rare, and may occur in the absence of any structural lesions to the hypothalamus,^[4] it may also be seen medically in association with hypothalmus/pituitary involvement in Diabetes Insipidus (Adipsic Diabetes Insipidus)^[5] and/or hypernatremia^[6] or following pituitary/hypothalmus surgery.^[7]

Testing

Initial testing for adipsia involves electrolyte, blood urea nitrogen and creatinine levels, serum and urine osmolality, blood hormone levels, like vassopressin. In patients who have defects in thirst regulation and vassopresin secretion, serum vassopresin levels are low or absent.^[8]

References

^ Crawford, M. A.; Kittleson, M. D.; Fink, G. D. (1984). "Hypernatremia and adipsia in a dog". Journal of the American Veterinary Medical Association 184 (7): 818–21. PMID 6725116. edit
^ http://www.britannica.com/EBchecked/topic/5956/adipsia
^ http://e-enm.org/search.php?where=aview&id=10.3803/EnM.2012.27.3.232&code=2008ENM&vmode=PUBREADER
^ Hayek, A; Peake, G. T. (1982). "Hypothalamic adipsia without demonstrable structural lesion". Pediatrics 70 (2): 275–8. PMID 6808452. edit
^ Crowley, R. K.; Sherlock, M; Agha, A; Smith, D; Thompson, C. J. (2007). "Clinical insights into adipsic diabetes insipidus: A large case series". Clinical Endocrinology 66 (4): 475–82. doi:10.1111/j.1365-2265.2007.02754.x. PMID 17371462. edit
^ http://emedicine.medscape.com/article/981022-treatment
^ http://link.springer.com/article/10.1007%2Fs11102-006-8280-x#page-1
^ http://emedicine.medscape.com/article/981022-workup

UpToDate Contents

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1. 高ナトリウム血症の病因および評価 etiology and evaluation of hypernatremia
2. 腎性尿崩症の臨床症状および原因 clinical manifestations and causes of nephrogenic diabetes insipidus
3. 多尿および尿崩症の診断 diagnosis of polyuria and diabetes insipidus
4. 中枢性尿崩症の臨床症状および原因 clinical manifestations and causes of central diabetes insipidus
5. 中枢性尿崩症の治療 treatment of central diabetes insipidus

English Journal

Behavioral effects following repeated exposure to hexachloronaphthalene in rats.

Kilanowicz A, Wiaderna D, Lutz P, Szymczak W.SourceDepartment of Toxicology, Faculty of Pharmacy, Medical University, Lodz, Poland. anna.kilanowicz@umed.lodz.pl
Neurotoxicology.Neurotoxicology.2012 Jun;33(3):361-9. doi: 10.1016/j.neuro.2012.02.011. Epub 2012 Feb 25.
Polychlorinated naphthalenes (PCNs), including hexachloronaphthalene (HxCN), are widespread global environmental contaminants. Our experiments were aimed at assessing HxCN effects on motor behavior, long-term memory, pain sensitivity, magnitude of stress-induced analgesia, auditory function and sens
PMID 22387569

Objective assessment of thirst recovery in patients with adipsic diabetes insipidus.

Sinha A, Ball S, Jenkins A, Hale J, Cheetham T.SourceDepartment of Paediatric Endocrinology, Great North Children's Hospital, Newcastle-upon-Tyne, UK. Akash.sinha@nuth.nhs.uk
Pituitary.Pituitary.2011 Dec;14(4):307-11. doi: 10.1007/s11102-011-0294-3.
Adipsic diabetes insipidus (ADI) is characterised by impaired thirst and defective AVP secretion. We have assessed the thirst response to graded osmotic stimulation using a visual analog scale (VAS) in patients with a history of ADI following surgery for a craniopharyngioma. The patients were though
PMID 21301966

Involvement of nitric oxide in lipopolysaccharide induced anorexia.

Riediger T, Cordani C, Potes CS, Lutz TA.SourceInstitute of Veterinary Physiology, University of Zurich, Zurich, Switzerland. triedig@vetphys.uzh.ch
Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2010 Nov;97(1):112-20. doi: 10.1016/j.pbb.2010.04.015. Epub 2010 Apr 27.
Treatment with the bacterial endotoxin lipopolysaccharide (LPS) is a commonly used model to induce disease-related anorexia. Following LPS treatment inducible nitric oxide synthase (iNOS) is expressed in the hypothalamic arcuate nucleus (ARC), where nitric oxide (NO) inhibits orexigenic neurons. Int
PMID 20430051

Japanese Journal

Adipsia increases risk of death in patients with central diabetes insipidus

Arima Hiroshi,Wakabayashi Toshihiko,Nagatani Tetsuya,Fujii Masazumi,Hirakawa Akihiro,Murase Takashi,Yambe Yuko,Yamada Tsutomu,Yamakawa Fumiko,Yamamori Ikuo,Yamauchi Masako,Oiso Yutaka
Endocrine Journal 61(2), 143-148, 2014
… We have reviewed 149 patients with CDI in three hospitals using databases of the electronic medical recording systems, and examined whether adipsia could affect the morbidity and mortality in CDI patients with multivariable analyses. …
NAID 130004718261

脳脊髄液と血清から抗甲状腺抗体が検出された無飲症性高ナトリウム血症の犬の1例(内科学)

Kang Ji-Houn,Chang Dongwoo,Lee Young Won [他],NA Ki-Jeong,YANG Mhan-Pyo
The journal of veterinary medical science 69(7), 751-754, 2007-07-25
4歳,雄,体重27kgのラブラドルレトリーバーが,突然,精神遅滞や旋回運動,頭部を押付けるといった臨床徴候を呈した.この犬は水を好んで摂取することはなく,無敗症が持続し,人工的な高塩素血症を伴った高ナトリウム血症がみられた.一連の内分泌検査と画像検査所見から,甲状腺機能低下症が示唆され,脳脊髄液と血清からは抗甲状腺抗体の存在が明らかになった.レポチロキシンナトリウムを投与したところ,神経徴候は処置 …
NAID 110006366686