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1. 選択的セロトニン再取り込み阻害剤：薬理学、投与方法、および副作用selective serotonin reuptake inhibitors pharmacology administration and side effects [show details]
…Citalopram; Escitalopram; Fluoxetine; Fluvoxamine; Paroxetine; Sertraline ; The development of antidepressant medications has proceeded through different historical phases. Fluoxetine was synthesized in 1972 …
2. 小児単極性うつ病および薬物療法：薬剤の選択pediatric unipolar depression and pharmacotherapy choosing a medication [show details]
…first line pharmacotherapy is fluoxetine . There is more consistent, high quality evidence for the efficacy of fluoxetine than other antidepressants . The efficacy of fluoxetine is discussed elsewhere in this …
3. 小児や青年の不安障害への薬物療法pharmacotherapy for anxiety disorders in children and adolescents [show details]
…youths to either fluoxetine or placebo . No differences between groups were found between groups based on clinician and teacher ratings; parent ratings found participants assigned to fluoxetine improved compared …
4. 乳児への授乳による抗うつ薬およびベンゾジアゼピン曝露の安全性safety of infant exposure to antidepressants and benzodiazepines through breastfeeding [show details]
…discontinued fluoxetine after delivery (n = 38) . Nevertheless, weights in the infants exposed to fluoxetine through breast milk were judged to be adequate, based upon national norms. Fluoxetine has a long …
5. 妊娠中の抗うつ薬の服用および催奇形性やそのほかの悪影響が生じる危険性について：選択的セロトニン再取り込み阻害薬（SSRI）antenatal use of antidepressants and risk of teratogenicity and adverse pregnancy outcomes selective serotonin reuptake inhibitors ssris [show details]
…use of fluoxetine during pregnancy and an increased risk of birth defects . As an example, a meta-analysis of four studies (n >1,200,000 births) compared infants of mothers who used fluoxetine during pregnancy …

English Journal

Pharmacodynamics of ClpP Activating Antibiotic Combinations against Gram-Positive Pathogens.

Mroue N, Arya A, Brown Gandt A, Russell C, Han A, Gavrish E, LaFleur M.
Antimicrobial agents and chemotherapy. 2019 Oct;().
It is often difficult to cure endocarditis, osteomyelitis, and device-associated infections caused by Gram-positive pathogens, despite therapy with clinically appropriate antibiotics. This may be due to antibiotic tolerance or resistance development. Acyldepsipeptides are a class of bactericidal com
PMID 31611348

The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory Gene as a Novel Antibiotic Resistance Factor.

Thomy D, Culp E, Adamek M, Cheng EY, Ziemert N, Wright GD, Sass P, Brötz-Oesterhelt H.
Applied and environmental microbiology. 2019 Oct;85(20).
The increasing threat posed by multiresistant bacterial pathogens necessitates the discovery of novel antibacterials with unprecedented modes of action. ADEP1, a natural compound produced by NRRL 15010, is the prototype for a new class of acyldepsipeptide (ADEP) antibiotics. ADEP antibiotics deregu
PMID 31399403

Acyldepsipeptide probes facilitate specific detection of caseinolytic protease P independent of its oligomeric and activity state.

Eyermann B, Meixner M, Brötz-Oesterhelt H, Antes I, Sieber SA.
Chembiochem : a European journal of chemical biology. 2019 Sep;().
Caseinolytic protease P (ClpP) is a tetradecameric peptidase which assembles with chaperones such as ClpX to gain proteolytic activity. Acyldepsipeptides (ADEPs) represent small molecule mimics of ClpX, which bind into hydrophobic pockets on the apical site of the complex and thereby induce activati
PMID 31487112

Japanese Journal

並列言語ADETRAN4のVPP-500での利用と評価

今村俊幸,杉山和徳,野木達夫
情報処理学会研究報告. HPC,[ハイパフォーマンスコンピューティング] 58, 13-18, 1995-10-18
… 科学技術計算に現れる様々な数値計算においてADI法の様な交互方向の作用素分割によって並列化がうまくなされるという視点から並列計算スキームADEPSと共にアーキテクチャー・ADENAファミリーが野木により提唱されてきた。 …
NAID 110002932271

外傷を契機として症状が発現したMorgagni孔ヘルニアの1治験例

舘林孝幸,大貫恭正,伊藤秀幸,笹野進,西内正樹,新田澄郎
日本臨床外科医学会雑誌 54(10), 2574-2577, 1993
Morgagni孔ヘルニアは比較的稀な疾患である.症例は71歳,女性,肥満体型で分娩歴2回であった.外傷による右第4, 5肋骨骨折後9ヵ月目頃より徐々に呼吸困難,胸痛を訴え,胸部X線上,受傷直後には不明瞭だった右心横隔膜部の腫瘤影が,境界明瞭な大きな腫瘤影となり, CT上にても前縦隔に脂肪濃度の腫瘤影を認めたが確診できず,胸骨縦切開にて手術を行い大網を内容とするMorgagni孔ヘルニアと診断した …
NAID 130003598439

並列計算モデルPB対ADEPS

野木達夫
応用数理 3(3), 207-224, 1993
… On the other hand, the paper proposes the author's own model, say, ADEPS (Alternating Direction Execution of 'Parallel over Segments') and it shows that ADEPS allows directly to express many standard parallel schemes for many kinds of problems by using new parallel language ADETRAN4, which is also based upon ADEPS and is designed by the author. …
NAID 110007390440

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