アデノシルホモシステイン
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English Journal
- A metabolomics-driven approach reveals metabolic responses and mechanisms in the rat heart following myocardial infarction.
- Nam M1, Jung Y2, Ryu DH3, Hwang GS4.
- International journal of cardiology.Int J Cardiol.2017 Jan 15;227:239-246. doi: 10.1016/j.ijcard.2016.11.127. Epub 2016 Nov 11.
- BACKGROUND: Myocardial infarction (MI) is caused by myocardial necrosis resulting from prolonged ischemia. However, the biological mechanisms underlying MI remain unclear.METHODS: We evaluated metabolic and lipidomic changes in rat heart tissue from sham and MI at 1h, 1day and 10day after coronary l
- PMID 27852445
- Transient Kinetics Define a Complete Kinetic Model for Protein Arginine Methyltransferase 1.
- Hu H1, Luo C2, Zheng YG3.
- The Journal of biological chemistry.J Biol Chem.2016 Dec 23;291(52):26722-26738. doi: 10.1074/jbc.M116.757625. Epub 2016 Nov 10.
- Protein arginine methyltransferases (PRMTs) are the enzymes responsible for posttranslational methylation of protein arginine residues in eukaryotic cells, particularly within the histone tails. A detailed mechanistic model of PRMT-catalyzed methylation is currently lacking, but it is essential for
- PMID 27834681
- Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.
- Mattocks DA1, Mentch SJ2, Shneyder J1, Ables GP1, Sun D3, Richie JP Jr4, Locasale JW2, Nichenametla SN5.
- Experimental gerontology.Exp Gerontol.2016 Dec 7;88:1-8. doi: 10.1016/j.exger.2016.12.003. [Epub ahead of print]
- Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR die
- PMID 27940170
Japanese Journal
- Relationship between blood levels of methyl donor and folate and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study
- Journal of Clinical Biochemistry and Nutrition 54(2), 122-128, 2014
- NAID 130004879354
- Design and Synthesis of Amide Derivatives as S-Adenosyl-L-Homocysteine Hydrolase Inhibitors
- Identification of DJ-1-Associated Regions on Human Genes from SH-SY5Y Cells using Chromatin Immunoprecipitation Sequence Technique
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