関: cobamamide

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/19 17:13:25」(JST)

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Cobamamide (AdoCbl), which is also known as adenosylcobalamin and dibencozide, is, along with methylcobalamin (MeCbl), one of the active forms of vitamin B₁₂. As a nutritional supplement, it is available in tabletted form, but unlike cyanocobalamin, methylcobalamin, and hydroxocobalamin, it is not available in injectable form.

An enzyme that uses adenosylcobalamin as a cofactor is methylmalonyl-CoA mutase (MCM).

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1. 有機酸血症 organic acidemias

English Journal

Radical Use of Rossmann and TIM Barrel Architectures for Controlling Coenzyme B(12) Chemistry.

Dowling DP, Croft AK, Drennan CL.SourceHoward Hughes Medical Institute.
Annual review of biophysics.Annu Rev Biophys.2012 Jun 9;41:403-27.
The ability of enzymes to harness free-radical chemistry allows for some of the most amazing transformations in nature, including reduction of ribonucleotides and carbon skeleton rearrangements. Enzyme cofactors involved in this chemistry can be large and complex, such as adenosylcobalamin (coenzyme
PMID 22577824

Ultrafast Infrared Spectral Fingerprints of Vitamin B(12) and Related Cobalamins.

Jones AR, Russell HJ, Greetham GM, Towrie M, Hay S, Scrutton NS.SourceManchester Interdisciplinary Biocentre and Faculty of Life Sciences, University of Manchester , U.K.
The journal of physical chemistry. A.J Phys Chem A.2012 Jun 1. [Epub ahead of print]
Vitamin B(12) (cyanocobalamin, CNCbl) and its derivatives are structurally complex and functionally diverse biomolecules. The excited state and radical pair reaction dynamics that follow their photoexcitation have been previously studied in detail using UV-visible techniques. Similar time-resolved i
PMID 22612868

Japanese Journal

Purification and some properties of wild-type and N-terminal-truncated ethanolamine ammonia-lyase of Escherichia coli

Akita Keita,Hieda Naoki,Baba Nobuyuki [他],KAWAGUCHI Satoshi,SAKAMOTO Hirohisa,NAKANISHI Yuka,YAMANISHI Mamoru,MORI Koichi,TORAYA Tetsuo
The journal of biochemistry 147(1), 83-93, 2010-01-01
NAID 10027873305

微生物に学ぶビタミンＢ１２代謝のシステム酵素学

虎谷哲夫
薬学雑誌. 乙号 130(11), 1453-1462, 2010
… We have investigated bacterial adenosylcobalamin-dependent enzymes and elucidated their structure-based fine mechanisms. …
NAID 130000451695

ビタミンB_<12>補酵素関与酵素の再活性化タンパク質に関する研究

森光一
ビタミン 83(3), 95-110, 2009-03-25
… Adenosylcobalamin-dependent enzymes tend to inactivate holoenzyme accompanying the modification of the coenzyme. … We identified reactivating factors for inactivated holoenzymes of adenosylcobalamin-dependent diol dehydratase (DD), glycerol dehydratase (GD), and ethanolamine ammonia-lyase (EAL), i.e., DDR, GDR, and EALR, respectively. …
NAID 110007161410

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★リンクテーブル★

リンク元	「アデノシルコバラミン」「cobamamide」
拡張検索	「5'-deoxyadenosylcobalamin」

「アデノシルコバラミン」

Cobamamide
Systematic (IUPAC) name
	Coα-[α-(5,6-dimethylbenzimidazolyl)]-Coβ-; (5'-deoxy-5'-adenosyl)cobamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	US: OTC;
Identifiers
CAS Number	13870-90-1
ATC code	B03BA04
PubChem	CID 5459907
ChemSpider	16736117
KEGG	D00042
ChEBI	CHEBI:18408
Chemical data
Formula	C72H100CoN18O17P
Molar mass	1579.58 g/mol
	InChI InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31?,34?,35?,36?,37?,41-,52-,53-,56?,57+,59?,60?,61?,62?;4-,6-,7-,10-;/m11./s1 ; Key:ZIHHMGTYZOSFRC-CXGXMSGESA-L ;
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