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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/19 12:15:00」(JST)

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For the cancer of developing teeth, see ameloblastoma.

Adamantinoma (from the Greek word adamantinos, meaning "very hard"^[1]) is a rare bone cancer, making up less than 1% of all bone cancers.^[2] It almost always occurs in the bones of the lower leg^[3] and involves both epithelial and osteofibrous tissue.^[4]

The condition was first described by Fischer in 1913.^[5]^[6]

Presentation[edit source | edit]

Patients typically present with swelling with or without pain. The slow-growing tumor predominantly arises in long bones in a subcutaneous location (95% in the tibia or fibula).^[3] Most commonly, patients are in their second or third decade, but adamantinoma can occur over a wide age range.

Benign osteofibrous dysplasia may be a precursor of adamantinoma^[4]^[7] or a regressive phase of adamantinoma.^[8]

Histologically, islands of epithelial cells are found in a fibrous stroma. The tumor is typically well-demarcated, osteolytic and eccentric, with cystic zones resembling soap bubbles.^[2]

Treatment[edit source | edit]

Treatment consists of wide resection or amputation. Metastases are rare at presentation but may occur in up to 30% of patients during the disease course. Prognosis is excellent, with overall survival of 85% at 10 years, but is lower when wide surgical margins cannot be obtained. This tumor is insensitive to radiation so chemotherapy is not typically used unless the cancer has metastized to the lungs or other organs.^[2]

Prior name for ameloblastoma[edit source | edit]

The typically benign odontogenic tumor known as ameloblastoma was first recognized in 1827 by Cusack but did not yet have any designation.^[9] In 1885, this kind of odontogenic neoplasm was designated as an adamantinoma by Malassez^[10] and was finally renamed to the modern name ameloblastoma in 1930 by Ivey and Churchill.^[11]^[12] Some authors still confusingly misuse the term adamantinoma to describe ameloblastomas, however they differ in histology and frequency of malignancy.

References[edit source | edit]

^ Brazis PW, Miller NR, Lee AG, Holliday MJ (1995). "Neuro-ophthalmologic Aspects of Ameloblastoma". Skull Base Surg 5 (4): 233–44. doi:10.1055/s-2008-1058921. PMC 1656531. PMID 17170964.
^ ^a ^b ^c Ernest U. Conrad (2008). Orthopaedic Oncology: Diagnosis and Treatment. Thieme. pp. 143–145.
^ ^a ^b Jain D, Jain VK, Vasishta RK, Ranjan P, Kumar Y (2008). "Adamantinoma: A clinicopathological review and update". Diagn Pathol 3: 8. doi:10.1186/1746-1596-3-8. PMC 2276480. PMID 18279517.
^ ^a ^b Hatori M, Watanabe M, Hosaka M, Sasano H, Narita M, Kokubun S (May 2006). "A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature". Tohoku J. Exp. Med. 209 (1): 53–9. doi:10.1620/tjem.209.53. PMID 16636523.
^ "Adamantinoma: Overview - eMedicine". Archived from the original on 25 December 2008. Retrieved 2009-01-04.
^ Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.
^ Springfield DS, Rosenberg AE, Mankin HJ, Mindell ER. (1994). "Relationship between osteofibrous dysplasia and adamantinoma.". Clin Orthop Relat Res.: 234–44. PMID 7994967.
^ Gleason, Briana C., Liegl-Atzwanger, Bernadette. "Osteofibrous Dysplasia and Adamantinoma in Children and Adolescents: A Clinicopathologic Reappraisal". American Journal of Surgical Pathology 32 (3): 363–376. doi:10.1097/PAS.0b013e318150d53e.
^ J.W. Cusack (1827). "Report of the amputations of the lower jaw". Dublin Hosp Rec 4: 1–38.
^ L. Malassez (1885). "Sur Le role des debris epitheliaux papdentaires". Arch Physiol Norm Pathol 5: 309–340 6:379–449.
^ R.H. Ivey, H.R. Churchill, (1930). "The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin,". Am Assoc Dent Sch Trans 7: 240–245.
^ Madhup, R; Kirti, S; Bhatt, M; Srivastava, M; Sudhir, S; Srivastava, A (Jan 2006). "Giant ameloblastoma of jaw successfully treated by radiotherapy". Oral Oncology Extra 42 (1): 22–25. doi:10.1016/j.ooe.2005.08.004.

UpToDate Contents

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1. 小児および思春期における良性骨腫瘍：概要 benign bone tumors in children and adolescents an overview

English Journal

Adamantinoma of the distal femur diagnosed 5 years after initial surgery: a case report.

Cao K1,2, Susa M3, Watanabe I1, Nishimoto K1, Horiuchi K1, Sasaki A4, Hayashi Y4, Emoto K4, Kameyama K4, Nakamura M1, Matsumoto M1, Morioka H1.
Journal of medical case reports.J Med Case Rep.2016 Jun 23;10(1):185. doi: 10.1186/s13256-016-0974-8.
BACKGROUND: Adamantinoma arising in the femur is extremely rare. We report a case of an adamantinoma occurring in the right medial femoral condyle that was diagnosed 5 years after the primary surgery.CASE PRESENTATION: A 74-year-old Asian woman first complained of right knee pain without any cause.
PMID 27337984

Clinicopathological features of five unusual cases of intraosseous myoepithelial carcinomas, mimicking conventional primary bone tumours, including EWSR1 rearrangement in one case.

Rekhi B1, Joshi S2, Panchwagh Y3,4, Gulia A5, Borges A6,7, Bajpai J8, Jambehekar NA1, Pant V6, Mandholkar M3, Byregowda S5, Puri A5.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.APMIS.2016 Apr;124(4):278-90. doi: 10.1111/apm.12506. Epub 2016 Jan 14.
Primary intraosseous myoepithelial tumours, including carcinomas are rare tumours. The concept of histopathological spectrum of these tumours is evolving. We describe clinicopathological and immunohistochemical features of five myoepithelial carcinomas, including molecular cytogenetic results in one
PMID 26768122

18F-FDG PET/CT in staging and follow-up of adamantinoma.

Albano D1, Bosio G2, Bertagna F2.
Revista espanola de medicina nuclear e imagen molecular.Rev Esp Med Nucl Imagen Mol.2016 Mar 14. pii: S2253-654X(16)00023-8. doi: 10.1016/j.remn.2016.02.001. [Epub ahead of print]
PMID 26988310

Japanese Journal

骨線維性異形成の7例

中里智治,松下廉,山田聡,大塚隆信
中部日本整形外科災害外科学会雑誌. 中部日本整形外科災害外科学会抄録 50(1), 13-14, 2007-01-01
NAID 10018895105

Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report.

Namba Yuzaburo,Kimata Yoshihiro,Koshima Isao,Sugihara Shinsuke,Sato Tohru
Acta Medica Okayama 60(4), 233-236, 2006-08
… We treated a case with left tibial adamantinoma by use of a contralateral fibular osteoadiposal flap. …
NAID 120002305898

A Classic Adamantinoma Arising from Osteofibrous Dysplasia-like Adamantinoma in the Lower Leg : A Case Report and Review of the Literature

HATORI MASAHITO,WATANABE MIKA,HOSAKA MASAMI,SASANO HIRONOBU,NARITA MASAHARU,KOKUBUN SHOICHI
THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 209(1), 53-59, 2006-05-01
NAID 10017418775

Related Pictures

★リンクテーブル★

リンク元	「エナメル上皮腫」「アダマンチノーマ」
拡張検索	「adamantinomatous type」「pituitary adamantinoma」

「エナメル上皮腫」

Adamantinoma
	Classification and external resources
	; Micrograph of an adamantinoma showing the biphasic histomorphology. H&E stain..
ICD-O:	9310/0
DiseasesDB	31676
eMedicine	radio/11
MeSH	D050398

　　[★]

英: ameloblastoma
ラ: adamantinoma
同: アダマンチノーマ, アメロブラストーマ
関: 歯原性腫瘍

「アダマンチノーマ」

　　[★]

英: adamantinoma
関: エナメル上皮腫

「adamantinomatous type」

　　[★]

同: エナメル上皮腫型

「pituitary adamantinoma」

　　[★] 下垂体エナメル上皮腫

[pmid17170964-1] Brazis PW, Miller NR, Lee AG, Holliday MJ (1995). "Neuro-ophthalmologic Aspects of Ameloblastoma". Skull Base Surg 5 (4): 233–44. doi:10.1055/s-2008-1058921. PMC 1656531. PMID 17170964.

[Radiation-2] Ernest U. Conrad (2008). Orthopaedic Oncology: Diagnosis and Treatment. Thieme. pp. 143–145.

[pmid18279517-3] Jain D, Jain VK, Vasishta RK, Ranjan P, Kumar Y (2008). "Adamantinoma: A clinicopathological review and update". Diagn Pathol 3: 8. doi:10.1186/1746-1596-3-8. PMC 2276480. PMID 18279517.

[pmid16636523-4] Hatori M, Watanabe M, Hosaka M, Sasano H, Narita M, Kokubun S (May 2006). "A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature". Tohoku J. Exp. Med. 209 (1): 53–9. doi:10.1620/tjem.209.53. PMID 16636523.

[urlAdamantinoma:_Overview_-_eMedicine-5] "Adamantinoma: Overview - eMedicine". Archived from the original on 25 December 2008. Retrieved 2009-01-04.

[6] Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.

[7] Springfield DS, Rosenberg AE, Mankin HJ, Mindell ER. (1994). "Relationship between osteofibrous dysplasia and adamantinoma.". Clin Orthop Relat Res.: 234–44. PMID 7994967.

[8] Gleason, Briana C., Liegl-Atzwanger, Bernadette. "Osteofibrous Dysplasia and Adamantinoma in Children and Adolescents: A Clinicopathologic Reappraisal". American Journal of Surgical Pathology 32 (3): 363–376. doi:10.1097/PAS.0b013e318150d53e.

[Cusack-9] J.W. Cusack (1827). "Report of the amputations of the lower jaw". Dublin Hosp Rec 4: 1–38.

[Malassez-10] L. Malassez (1885). "Sur Le role des debris epitheliaux papdentaires". Arch Physiol Norm Pathol 5: 309–340 6:379–449.

[Ivey-11] R.H. Ivey, H.R. Churchill, (1930). "The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin,". Am Assoc Dent Sch Trans 7: 240–245.

[Madhup-12] Madhup, R; Kirti, S; Bhatt, M; Srivastava, M; Sudhir, S; Srivastava, A (Jan 2006). "Giant ameloblastoma of jaw successfully treated by radiotherapy". Oral Oncology Extra 42 (1): 22–25. doi:10.1016/j.ooe.2005.08.004.

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adamantinoma