同: Adalat, Procardia
関: Nifedipine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/21 13:39:25」(JST)

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1. 安定狭心症のマネージメントにおけるカルシウム拮抗剤 calcium channel blockers in the management of stable angina pectoris
2. アテローム性心血管疾患患者における目標血圧の意義 what is the goal blood pressure in patients with atherosclerotic cardiovascular disease
3. 裂肛：内科的および外科的マネージメント anal fissure medical and surgical management
4. 切迫早産の予防 inhibition of acute preterm labor
5. カルシウム拮抗剤の主な副作用および安全性 major side effects and safety of calcium channel blockers

English Journal

Confirmed efficacy of topical nifedipine in the treatment of facial wrinkles.

Calabrò G1, De Vita V, Patalano A, Mazzella C, Lo Conte V, Antropoli C.Author information 1Department of Dermatology, University of Naples Federico II , Naples , Italy.AbstractINTRODUCTION: Over the past two decades, there has been increasing demand for aesthetic procedures to reverse the effects of aging, particularly in the facial area. Recently, topical nifedipine has been proposed for its anti-wrinkle efficacy.
The Journal of dermatological treatment.J Dermatolog Treat.2014 Aug;25(4):319-25. doi: 10.3109/09546634.2013.802759. Epub 2013 Jun 2.
INTRODUCTION: Over the past two decades, there has been increasing demand for aesthetic procedures to reverse the effects of aging, particularly in the facial area. Recently, topical nifedipine has been proposed for its anti-wrinkle efficacy.OBJECTIVE: To confirm the anti-wrinkle efficacy of a 0.5%
PMID 23688162

Effect of storage conditions on the recrystallization of drugs in solid dispersions with crospovidone.

Shibata Y1, Fujii M, Suzuki A, Koizumi N, Kanada K, Yamada M, Watanabe Y.Author information 1Pharmaceutical Research Laboratories, Kissei Pharmaceutical Co, Ltd , Azumino-city, Nagano , Japan and.AbstractThe physical stability of amorphous solid dispersions (SDs) is influenced by their storage conditions. The goal of this work was to investigate the factors affecting the recrystallization of drugs in SDs after storage under conditions of high temperature and high humidity. SDs of three drugs (dipyridamole, nifedipine and indomethacin) with different functional groups (amino, carbonyl and hydroxyl) and onset times for crystallization of the amorphous state were prepared using crospovidone (CrosPVP). All of the drugs in the SDs remained in an amorphous state at 25 °C/50% relative humidity (RH) in closed glass bottles for at least six months. Under conditions of high temperature (40 °C/75%RH/closed and 60 °C/open), differences in interactions between the hydrogen bond donors of the drugs and the amide carbonyl group of CrosPVP are essential factors for recrystallization of the drugs in the SDs. On the other hand, under condition of high humidity (40 °C/75%RH/open), in addition to the difference in the interaction between the drug and CrosPVP, the rate of increase in moisture content affects their recrystallization in SDs.
Pharmaceutical development and technology.Pharm Dev Technol.2014 Jun;19(4):468-74. doi: 10.3109/10837450.2013.795168. Epub 2013 May 17.
The physical stability of amorphous solid dispersions (SDs) is influenced by their storage conditions. The goal of this work was to investigate the factors affecting the recrystallization of drugs in SDs after storage under conditions of high temperature and high humidity. SDs of three drugs (dipyri
PMID 23682860

Differential Effects of the Gβ5-RGS7 Complex on Muscarinic M3 Receptor-Induced Ca2+ Influx and Release.

Karpinsky-Semper D1, Volmar CH, Brothers SP, Slepak VZ.Author information 1Department of Molecular and Cellular Pharmacology (D.K.-S., V.Z.S.) and Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences (C.-H.V., S.P.B.), University of Miami Miller School of Medicine, Miami, Florida.AbstractThe G protein β subunit Gβ5 uniquely forms heterodimers with R7 family regulators of G protein signaling (RGS) proteins (RGS6, RGS7, RGS9, and RGS11) instead of Gγ. Although the Gβ5-RGS7 complex attenuates Ca(2+) signaling mediated by the muscarinic M3 receptor (M3R), the route of Ca(2+) entry (i.e., release from intracellular stores and/or influx across the plasma membrane) is unknown. Here, we show that, in addition to suppressing carbachol-stimulated Ca(2+) release, Gβ5-RGS7 enhanced Ca(2+) influx. This novel effect of Gβ5-RGS7 was blocked by nifedipine and 2-aminoethoxydiphenyl borate. Experiments with pertussis toxin, an RGS domain-deficient mutant of RGS7, and UBO-QIC {L-threonine,(3R)-N-acetyl-3-hydroxy-L-leucyl-(aR)-a-hydroxybenzenepropanoyl-2,3-idehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-3-hydroxy-4- methyl-1-oxo-2-[(1-oxopropyl)amino]pentyl]oxy]-L-leucyl-N,O-dimethyl-,(7→1)-lactone (9CI)}, a novel inhibitor of Gq, showed that Gβ5-RGS7 modulated a Gq-mediated pathway. These studies indicate that Gβ5-RGS7, independent of RGS7 GTPase-accelerating protein activity, couples M3R to a nifedipine-sensitive Ca(2+) channel. We also compared the action of Gβ5-RGS7 on M3R-induced Ca(2+) influx and release elicited by different muscarinic agonists. Responses to Oxo-M [oxotremorine methiodide N,N,N,-trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide] were insensitive to Gβ5-RGS7. Pilocarpine responses consisted of a large release and modest influx components, of which the former was strongly inhibited whereas the latter was insensitive to Gβ5-RGS7. McN-A-343 [(4-hydroxy-2-butynyl)-1-trimethylammonium-3-chlorocarbanilate chloride] was the only compound whose total Ca(2+) response was enhanced by Gβ5-RGS7, attributed to, in part, by the relatively small Ca(2+) release this partial agonist stimulated. Together, these results show that distinct agonists not only have differential M3R functional selectivity, but also confer specific sensitivity to the Gβ5-RGS7 complex.
Molecular pharmacology.Mol Pharmacol.2014 May;85(5):758-68. doi: 10.1124/mol.114.091843. Epub 2014 Feb 28.
The G protein β subunit Gβ5 uniquely forms heterodimers with R7 family regulators of G protein signaling (RGS) proteins (RGS6, RGS7, RGS9, and RGS11) instead of Gγ. Although the Gβ5-RGS7 complex attenuates Ca(2+) signaling mediated by the muscarinic M3 receptor (M3R), the route of Ca(2+) entry (
PMID 24586057

Japanese Journal

Effects of treatment with once-daily nifedipine CR and twice-daily benidipine on prevention of symptomatic attacks in patients with coronary spastic angina pectoris-Adalat Trial vs Coniel in Tokyo against Coronary Spastic Angina (ATTACK CSA)

OIKAWA Yuji,MATSUNO Syunsuke,YAJIMA Junji,NAKAMURA Masato,ONO Tsuyoshi,ISHIWATA Sugao,FUJIMOTO Yo,AIZAWA Tadanori
Journal of cardiology 55(2), 238-247, 2010-03-15
NAID 10027052203

本態性高血圧患者における先発医薬品(アダラートCR)から後発医薬品(コリネールCR)への切り替えに関する臨床評価

菊池大輔,小原拓,高橋則男 [他]
ジェネリック研究 2(1), 37-43, 2008-08
NAID 40016294512

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