the process of introducing an acyl group into a compound
English Journal
Revisiting the metabolism and physiological functions of caprylic acid (C8:0) with special focus on ghrelin octanoylation.
Lemarié F1, Beauchamp E1, Legrand P1, Rioux V2.
Biochimie.Biochimie.2015 Aug 4. pii: S0300-9084(15)00249-7. doi: 10.1016/j.biochi.2015.08.002. [Epub ahead of print]
Caprylic acid (octanoic acid, C8:0) belongs to the class of medium-chain saturated fatty acids (MCFAs). Dairy products and specific oils like coconut oil are natural sources of dietary C8:0 but higher intakes of this fatty acid can be provided with MCT (Medium-Chain Triglycerides) oil that consists
The Journal of biological chemistry.J Biol Chem.2015 Jul 29. pii: jbc.M115.651356. [Epub ahead of print]
Protein S-acyltransferases, also known as palmitoyltransferases (PATs), are characterized by the presence of a 50 amino acid domain called the DHHC domain. Within this domain, these four amino acids constitute a highly conserved motif. It has been proposed that the palmitoylation reaction occurs thr
We utilized several computational approaches to evaluate the binding energies of tyrosine (Tyr) and several unnatural Tyr analogs, to several orthogonal aaRSes derived from Methanocaldococcus jannaschii and Escherichia coli tyrosyl-tRNA synthetases. The present study reveals the following: (1) AutoD
Rearrangements of 1, 2-epoxy alcohol derivatives having electron-withdrawing protective groups such as acyl or sulfonyl group have been developed leading to the asymmetric construction of chiral quate …
Acyl halides and anhydrides of carboxylic acids are also commonly used acylating agents to acylate amines to form amides or acylate alcohols to form esters. The amines and alcohols are nucleophiles; the mechanism is nucleophilic ...