English Journal

Effect of acyl chain length on selective biocatalytic deacylation on O-aryl glycosides and separation of anomers.

Aggarwal N1, Arya A1, Mathur D1, Singh S1, Tyagi A1, Kumar R1, Rana N1, Singh R2, Prasad AK3.
Bioorganic chemistry.Bioorg Chem.2014 Apr;53:83-91. doi: 10.1016/j.bioorg.2014.02.004. Epub 2014 Feb 22.
It has been demonstrated that Lipozyme® TL IM (Thermomyces lanuginosus lipase immobilised on silica) can selectively deacylate the ester function involving the C-5' hydroxyl group of α-anomers over the other acyl functions of anomeric mixture of peracylated O-aryl α,β-D-ribofuranoside. The analy
PMID 24632507

Smith CA1, Antunes NT, Toth M, Vakulenko SB.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2014;58(4):2135-43. doi: 10.1128/AAC.01983-13. Epub 2014 Jan 27.
Class D β-lactamases capable of hydrolyzing last-resort carbapenem antibiotics represent a major challenge for treatment of bacterial infections. Wide dissemination of these enzymes in Acinetobacter baumannii elevated this pathogen to the category of most deadly and difficult to treat. We present h
PMID 24468777

Pollegioni L1, Rosini E, Molla G.
Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2013 Mar;97(6):2341-55. doi: 10.1007/s00253-013-4741-0. Epub 2013 Feb 16.
Cephalosporins currently constitute the most widely prescribed class of antibiotics and are used to treat diseases caused by both Gram-positive and Gram-negative bacteria. Cephalosporins contain a 7-aminocephalosporanic acid (7-ACA) nucleus which is derived from cephalosporin C (CephC). The 7-ACA nu
PMID 23417342