- 関
- acrosome
WordNet
- a process at the anterior end of a sperm cell that produces enzymes to facilitate penetration of the egg
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/25 21:36:38」(JST)
[Wiki en表示]
The acrosome is an organelle that develops over the anterior half of the head in the spermatozoa (sperm cells) of many animals. It is a cap-like structure derived from the Golgi apparatus. Acrosome formation is completed during testicular maturation. In Eutherian mammals the acrosome contains digestive enzymes (including hyaluronidase and acrosin).[1] These enzymes break down the outer membrane of the ovum, called the zona pellucida, allowing the haploid nucleus in the sperm cell to join with the haploid nucleus in the ovum.
This shedding of the acrosome, or acrosome reaction, can be stimulated in vitro by substances a sperm cell may encounter naturally such as progesterone or follicular fluid, as well as the more commonly used calcium ionophore A23187. This can be done to serve as a positive control when assessing the acrosome reaction of a sperm sample by flow cytometry[2] or fluorescence microscopy. This is usually done after staining with a fluoresceinated lectin such as FITC-PNA, FITC-PSA, FITC-ConA, or fluoresceinated antibody such as FITC-CD46.[3]
In the case of globozoospermia (sperm with round heads), the Golgi apparatus is not transformed into the acrosome, causing male infertility.[4]
References
- ^ "acrosome definition - Dictionary - MSN Encarta". Archived from the original on 2009-10-31. Retrieved 2007-08-15.
- ^ Miyazaki R, Fukuda M, Takeuchi H, Itoh S, Takada M (1990). "Flow cytometry to evaluate acrosome-reacted sperm". Arch. Androl. 25 (3): 243–51. doi:10.3109/01485019008987613. PMID 2285347.
- ^ Carver-Ward JA, Moran-Verbeek IM, Hollanders JM (February 1997). "Comparative flow cytometric analysis of the human sperm acrosome reaction using CD46 antibody and lectins". J. Assist. Reprod. Genet. 14 (2): 111–9. doi:10.1007/bf02765780. PMC 3454831. PMID 9048242.
- ^ Hermann Behre; Eberhard Nieschlag (2000). Andrology : Male Reproductive Health and Dysfunction. Berlin: Springer. p. 155. ISBN 3-540-67224-9.
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Structures of the cell / organelles (TH H1.00.01.2-3)
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| Endomembrane system |
- Cell membrane
- Nucleus
- Nucleolus
- Endoplasmic reticulum
- Golgi apparatus
- Parenthesome
- Autophagosome
- Vesicles
- Exosome
- Lysosome
- Endosome
- Phagosome
- Vacuole
- Cytoplasmic granules
- Melanosome
- Microbody
- Glyoxysome
- Peroxisome
- Weibel–Palade body
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| Cytoskeleton |
- Microfilaments
- Intermediate filaments
- Microtubules
- Prokaryotic cytoskeleton
- MTOCs
- Centrosome
- Centriole
- Basal body
- Spindle pole body
- Myofibril
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| Endosymbionts |
- Mitochondrion
- Plastids
- Chloroplast
- Chromoplast
- Gerontoplast
- Leucoplast
- Amyloplast
- Elaioplast
- Proteinoplast
- Tannosome
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| Other internal |
- RNA
- Ribosome
- Spliceosome
- Vault
- Cytoplasm
- Proteasome
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| External |
- Undulipodium
- Cilium
- Flagellum
- Axoneme
- Radial spoke
- Extracellular matrix
- Acrosome
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B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)
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UpToDate Contents
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- 1. 男性生殖生理学 male reproductive physiology
- 2. 男性不妊症の評価 evaluation of male infertility
- 3. 子宮内避妊：器具、候補および選択 intrauterine contraception devices candidates and selection
English Journal
- Characterization and possible function of glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein GAPDHS in mammalian sperm.
- Margaryan H1, Dorosh A, Capkova J, Manaskova-Postlerova P, Philimonenko A, Hozak P, Peknicova J.
- Reproductive biology and endocrinology : RB&E.Reprod Biol Endocrinol.2015 Dec;13(1):8. doi: 10.1186/s12958-015-0008-1. Epub 2015 Mar 8.
- BACKGROUND: Sperm proteins are important for the sperm cell function in fertilization. Some of them are involved in the binding of sperm to the egg. We characterized the acrosomal sperm protein detected by a monoclonal antibody (MoAb) (Hs-8) that was prepared in our laboratory by immunization of BAL
- PMID 25778484
- Characterization of BRD4 during Mammalian Postmeiotic Sperm Development.
- Bryant JM1, Donahue G2, Wang X3, Meyer-Ficca M4, Luense LJ2, Weller AH2, Bartolomei MS2, Blobel GA5, Meyer RG4, Garcia BA3, Berger SL6.
- Molecular and cellular biology.Mol Cell Biol.2015 Apr 15;35(8):1433-48. doi: 10.1128/MCB.01328-14. Epub 2015 Feb 17.
- During spermiogenesis, the postmeiotic phase of mammalian spermatogenesis, transcription is progressively repressed as nuclei of haploid spermatids are compacted through a dramatic chromatin reorganization involving hyperacetylation and replacement of most histones with protamines. Although BRDT fun
- PMID 25691659
- P38 participates in spermatogenesis and acrosome reaction prior to fertilization in Chinese mitten crab Eriocheir sinensis.
- Zhu M1, Sun WJ1, Wang YL1, Li Q1, Yang HD1, Duan ZL1, He L2, Wang Q3.
- Gene.Gene.2015 Apr 1;559(2):103-11. doi: 10.1016/j.gene.2014.11.050. Epub 2014 Nov 26.
- P38 mitogen-activated protein kinases (MAPKs) comprise a family of serine/threonine protein kinases that play important roles in cellular responses to inflammatory cytokines and environmental stresses. These kinases are involved in controlling cell division, differentiation and death in mammalian te
- PMID 25433091
Japanese Journal
- Effects of acrosomal conditions of frozen-thawed spermatozoa on the results of artificial insemination in Japanese Black cattle
- KISHIDA Kazumi,SAKASE Mitsuhiro,MINAMI Kenta,ARAI Miyuki M.,SYOJI Reiko,KOHAMA Namiko,AKIYAMA Takayuki,OKA Akio,HARAYAMA Hiroshi,FUKUSHIMA Moriyuki
- Journal of Reproduction and Development advpub(0), 2015
- … The purposes of this study were to examine the relationship between male artificial insemination (AI) fertility and sperm acrosomal conditions assessed by new and conventional staining techniques and to identify possible reproductive dysfunctions causing low conception rates in AI using frozen-thawed spermatozoa with poor acrosomal conditions in Japanese Black bulls. …
- NAID 130005093794
- Glutathione supplementation to semen extender improves the quality of frozen-thawed canine spermatozoa for transcervical insemination
- OGATA Kazuko,SASAKI Aiko,KATO Yuka,TAKEDA Arisa,WAKABAYASHI Mikio,SARENTONGLAGA Borjigin,YAMAGUCHI Mio,HARA Asuka,FUKUMORI Rika,NAGAO Yoshikazu
- Journal of Reproduction and Development 61(2), 116-122, 2015
- … These results indicate that supplementation of semen extender with 5 mM GSH was effective in improving motility, longevity and acrosomal integrity and inhibiting LP levels in post-thaw canine spermatozoa, without any adverse impacts on full-term development after transcervical insemination. …
- NAID 130005064910
- Glutathione supplementation to semen extender improves the quality of frozen-thawed canine spermatozoa for transcervical insemination
- OGATA Kazuko,SASAKI Aiko,KATO Yuka,TAKEDA Arisa,WAKABAYASHI Mikio,SARENTONGLAGA Borjigin,YAMAGUCHI Mio,HARA Asuka,FUKUMORI Rika,NAGAO Yoshikazu
- Journal of Reproduction and Development advpub(0), 2015
- … These results indicate that supplementation of semen extender with 5 mM GSH was effective in improving motility, longevity and acrosomal integrity and inhibiting LP levels in post-thaw canine spermatozoa, without any adverse impacts on full-term development after transcervical insemination. …
- NAID 130004774194
Related Links
- acrosomal /ac·ro·so·mal/ (ak″ro-so´mal) pertaining to the acrosome. acrosome (ak'ro-som?) [ acro-+ -some] A specialized lysosome on the head of a sperm cell that contains enzymes to digest the membrane of an egg cell. acrosomal (ak?ro-so'mal), ...
- Define acrosomal. acrosomal synonyms, acrosomal pronunciation, acrosomal translation, English dictionary definition of acrosomal. n. A caplike structure at the anterior end of a spermatozoon that produces enzymes aiding in ...