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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/06 20:59:04」(JST)

English Journal

Effects of synthetic and natural in vivo inhibitors of β-glucuronidase on azoxymethane-induced colon carcinogenesis in rats.

Morita N, Walaszek Z, Kinjo T, Nishimaki T, Hanausek M, Slaga TJ, Mori H, Yoshimi N.SourceTumor Pathology, University of the Ryukyus, 207 Uehara, Japan.
Molecular medicine reports.Mol Med Rep.2008 Sep-Oct;1(5):741-6. doi: 10.3892/mmr_00000022.
D-Glucaric acid is a non-toxic natural compound found in many fruits and vegetables. Our previous studies have shown that the β-glucuronidase inhibitor D-glucaro-1,4-lactone, an active metabolite of D-glucaric acid, inhibits chemically-induced tumorigenesis in rodents. D-Glucaro-1,4-lactone has a s
PMID 21479479

[Study of preventive effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU) or combination of HCFU and 2.5-di-O-acetyl-D-glucaro (1-4) (6-3) dilactone (SLA) after preservative operation against bladder cancer].

Wada S, Yasumoto R, Kashihara N, Kishimoto T, Maekawa M, Hayahara N, Kawakita J, Nishijima T, Morikawa Y, Horii A, et al.SourceDepartment of Urology, Osaka City University Medical School.
Hinyokika kiyo. Acta urologica Japonica.Hinyokika Kiyo.1992 Jan;38(1):19-24.
To treat superficial bladder cancer or invasive bladder cancer presenting as a solitary tumor, conservative therapy such as transurethral resection of bladder tumor or partial cystectomy has long been carried out. We studied the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), and the effects of th
PMID 1546564

Repression by sustained-release beta-glucuronidase inhibitors of chemical carcinogen-mediated induction of a marker oncofetal protein in rodents.

Walaszek Z, Hanausek-Walaszek M, Webb TE.SourceDepartment of Physiological Chemistry, Ohio State University College of Medicine, Columbus.
Journal of toxicology and environmental health.J Toxicol Environ Health.1988;23(1):15-27.
The degree of induction of an oncofetal protein marker in rodents by selected chemical carcinogens has been correlated with changes in carcinogenicity induced by dietary D-glucaro-1,4-lactone (GL) based anticarcinogens. These potent anticarcinogens may act to increase the clearance of carcinogens as
PMID 3336058

リンク元

Aceglatone
v; t; e;
Systematic (IUPAC) name
	(3R,3aR,6S,6aR)-2,5-Dioxohexahydrofuro[3,2-b]furan-3,6-diyl diacetate
Clinical data
Trade names	Glucaron
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	642-83-1
ATC code	?
PubChem	CID 636372
ChemSpider	599998
UNII	347Q3OOJ13
Synonyms	D-Glucaric acid di-γ-lactone 2,5-diacetate; 2,5-Di-O-acetyl-D-glucaro-1,4:6,3-dilactone; 2,5-Di-O-acetyl-D-glucosaccharo-1,4:6,3-dilactone
Chemical data
Formula	C10H10O8
Mol. mass	258.18 g/mol
	SMILES O=C1O[C@H]2[C@@H](OC(=O)C)C(=O)O[C@H]2[C@@H]1OC(=O)C;
	InChI InChI=1S/C10H10O8/c1-3(11)15-7-5-6(18-9(7)13)8(10(14)17-5)16-4(2)12/h5-8H,1-2H3/t5-,6-,7-,8+/m1/s1 ; Key:ZOZKYEHVNDEUCO-XUTVFYLZSA-N ;
Physical data
Melt. point	185–186 °C (365–367 °F)
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