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- トロフェリマ・ウィッペリ
- ラ
- Tropheryma whipplei
- 関
- ウィップル病、トロフェリマ属
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Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/11 14:18:51」(JST)
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| Tropheryma whipplei |
| Scientific classification |
| Kingdom: |
Bacteria |
| Phylum: |
Actinobacteria |
| Class: |
Actinobacteria |
| Subclass: |
Actinobacteridae |
| Order: |
Actinomycetales |
| Family: |
Cellulomonadaceae |
| Genus: |
Tropheryma |
| Species: |
T. whipplei |
| Binomial name |
Tropheryma whipplei
La Scola et al. 2001 |
Tropheryma whipplei, formerly called Tropheryma whippelii,[1] is a bacterium and the causative organism of Whipple's disease.[2]
While T. whipplei is categorized with the Gram-positive Actinobacteria, the organism is commonly found to be Gram-negative or Gram-indeterminate when stained in the laboratory.[2] Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case.[3]
History of the name
No name was given to the organism until 1991 when the name Tropheryma[4] whippelii was proposed after sections of the bacterial genome were sequenced.[5] The name was changed to Tropheryma whipplei in 2001 (correcting the spelling of Whipple's name) when the organism was deposited in bacterial collections.[2]
Pathogenesis
-
Main article: Whipple's disease
References
- ^ Liang Z, La Scola B, Raoult D (January 2002). "Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei". Clin. Diagn. Lab. Immunol. 9 (1): 156–9. doi:10.1128/CDLI.9.1.156-159.2002. PMC 119894. PMID 11777846. http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=11777846.
- ^ a b c La Scola B, Fenollar F, Fournier PE, Altwegg M, Mallet MN, Raoult D (July 2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". Int. J. Syst. Evol. Microbiol. 51 (Pt 4): 1471–9. PMID 11491348. http://ijs.sgmjournals.org/cgi/pmidlookup?view=long&pmid=11491348.
- ^ Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues". Johns Hopkins Hosp Bull 18: 382–91.
- ^ From Greek τροφή trophê, "nourishment, food" and ἔρυμα eruma, "fence, a defence against, barrier".
- ^ Relman D, Schmidt T, MacDermott R, Falkow S (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med 327 (5): 293–301. doi:10.1056/NEJM199207303270501. PMID 1377787.
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Actinobacteria (high-G+C) Infectious diseases · Bacterial diseases: G+ (primarily A00–A79, 001–041, 080–109)
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| Actinomycineae |
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Actinomycetaceae
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Actinomyces israelii (Actinomycosis, Cutaneous actinomycosis) · Tropheryma whipplei (Whipple's disease) · Arcanobacterium haemolyticum (Arcanobacterium haemolyticum infection)
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|
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Propionibacteriaceae
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Propionibacterium acnes
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|
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| Corynebacterineae |
|
Mycobacteriaceae
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|
M. tuberculosis/
M. bovis
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Tuberculosis: Ghon focus/Ghon's complex · Pott disease · brain (Meningitis, Rich focus) · Tuberculous lymphadenitis (Tuberculous cervical lymphadenitis) · cutaneous (Scrofuloderma, Erythema induratum, Lupus vulgaris, Prosector's wart, Tuberculosis cutis orificialis, Tuberculous cellulitis, Tuberculous gumma) · Lichen scrofulosorum · Tuberculid (Papulonecrotic tuberculid) · Primary inoculation tuberculosis · Miliary · Tuberculous pericarditis · Urogenital tuberculosis · Multi-drug-resistant tuberculosis · Extensively drug-resistant tuberculosis
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|
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M. leprae
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Leprosy: Tuberculoid leprosy · Borderline tuberculoid leprosy · Borderline leprosy · Borderline lepromatous leprosy · Lepromatous leprosy · Histoid leprosy
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Nontuberculous
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R1: M. kansasii · M. marinum (Aquarium granuloma)
R2: M. gordonae
R3: M. avium complex/Mycobacterium avium/Mycobacterium intracellulare/MAP (MAI infection) · M. ulcerans (Buruli ulcer) · M. haemophilum
R4/RG: M. fortuitum · M. chelonae · M. abscessus
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Nocardiaceae
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Nocardia asteroides/Nocardia brasiliensis (Nocardiosis) · Rhodococcus equi
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Corynebacteriaceae
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Corynebacterium diphtheriae (Diphtheria) · Corynebacterium minutissimum (Erythrasma) · Corynebacterium jeikeium (Group JK corynebacterium sepsis)
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| Bifidobacteriaceae |
Gardnerella vaginalis
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gr+f/gr+a (t)/gr-p (c)/gr-o
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drug (J1p, w, n, m, vacc)
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UpToDate Contents
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English Journal
- [Whipple's disease in an elderly patient with a substantial weight loss and gastrointestinal symptoms.]
- Jensen MB1, Stawowy M, Christiansen J.
- Ugeskrift for laeger.Ugeskr Laeger.2014 Dec 15;176(25A). pii: V12120724.
- Whipple's disease is a multisystemic infection with Tropheryma whipplei often characterised by its gastrointestinal involvement. However, due to the broad spectrum of unspecific symptoms, the diagnosis is often delayed. We report a case of a 70 year-old-man, who presented with extensive weight loss
- PMID 25497640
- [Whipple's disease and Tropheryma whipplei infections in internal medicine. When thinking about it? How to treat?].
- Lagier JC1, Fenollar F1, Raoult D2.
- La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne.Rev Med Interne.2014 Dec;35(12):801-7. doi: 10.1016/j.revmed.2014.04.016. Epub 2014 Jun 2.
- Tropheryma whipplei culture and genome sequencing have, thanks to new tools, rationalized both diagnosis and treatment of Whipple's disease. Whipple's disease involves mainly Caucasian male, approximately 50-years-old, suffering from arthralgia, weight loss and diarrhea. A worsening of clinical mani
- PMID 24933290
- Gorilla gorilla gorilla gut: a potential reservoir of pathogenic bacteria as revealed using culturomics and molecular tools.
- Bittar F1, Keita MB1, Lagier JC1, Peeters M2, Delaporte E2, Raoult D1.
- Scientific reports.Sci Rep.2014 Nov 24;4:7174. doi: 10.1038/srep07174.
- Wild apes are considered to be the most serious reservoir and source of zoonoses. However, little data are available about the gut microbiota and pathogenic bacteria in gorillas. For this propose, a total of 48 fecal samples obtained from 21 Gorilla gorilla gorilla individuals (as revealed via micro
- PMID 25417711
Japanese Journal
- Whipple Disease Diagnosed with PCR Using Formalin-fixed Paraffin-embedded Specimens of the Intestinal Mucosa
- Yajima Nobuhisa,Wada Ryuichi,Kimura Sotai,Matsuzaki Yutaka,Chiba Daisuke,Ebina Yoshihito,Ohkusu Kiyofumi,Yagihashi Soroku
- Internal Medicine 52(2), 219-222, 2013
- … PCR using FFPE specimens amplified a fragment of 16S rDNA from Tropheryma whipplei. …
- NAID 130003365854
- Central Nervous System Relapse of Whipple's Disease
- Uryu Kiyoaki,Sakai Takashi,Yamamoto Tomonori,Mae Takahito,Willard Yoshie Iwasaki,Sugita Hiroji,Asano Koukichi,Yamashita Kenichi,Harada Hiromasa,Fukuda Kou
- Internal Medicine 51(15), 2045-2050, 2012
- … Tropheryma whipplei DNA was detected by a polymerase chain reaction in his cerebrospinal fluid. …
- NAID 130002062266
- 大久保 智恵,藤崎 智明,横田 英介 [他],川崎 啓祐,大城 由美
- 日本内科学会雑誌 98(10), 2598-2600, 2009-10-10
- … Whipple病は放線菌近縁のグラム陽性桿菌Tropheryma whipplei（T. …
- NAID 10025609871
Related Links
- Tropheryma whipplei is rod shaped, a gram-postive bacterium (5). It was finally isolated in eukaryotic cells in the year 2000 and propagated in culture at thirty-seven degrees Celsius, but was believed to resist culturing for a long time ...
- Tropheryma whipplei endocarditis differs from classic Whipple disease, which primarily affects the gastrointestinal system. We diagnosed 28 cases of T. whipplei endocarditis in Marseille, France, and compared them with cases ...
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