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- Tropheryma whipplei
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/23 03:32:16」(JST)
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Tropheryma whipplei |
Scientific classification |
Kingdom: |
Bacteria |
Phylum: |
Actinobacteria |
Class: |
Actinobacteria |
Subclass: |
Actinobacteridae |
Order: |
Actinomycetales |
Family: |
Cellulomonadaceae |
Genus: |
Tropheryma |
Species: |
T. whipplei |
Binomial name |
Tropheryma whipplei
La Scola et al. 2001 |
Tropheryma whipplei, formerly called Tropheryma whippelii,[1] is a bacterium and the causative organism of Whipple's disease[2] and rarely endocarditis.
While T. whipplei is categorized with the Gram-positive Actinobacteria, the organism is commonly found to be Gram-negative or Gram-indeterminate when stained in the laboratory.[2] Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case.[3]
Contents
- 1 History of the name
- 2 Pathogenesis
- 3 Genome structure
- 4 References
History of the name
No name was given to the organism until 1991 when the name Tropheryma[4] whippelii was proposed after sections of the bacterial genome were sequenced.[5] The name was changed to Tropheryma whipplei in 2001 (correcting the spelling of Whipple's name) when the organism was deposited in bacterial collections.[2]
Pathogenesis
Main article: Whipple's disease
Genome structure
Several strains of Tropheryma whipplei have been sequenced.[6][7]
References
- ^ Liang Z, La Scola B, Raoult D; La Scola; Raoult (January 2002). "Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei". Clin. Diagn. Lab. Immunol. 9 (1): 156–9. doi:10.1128/CDLI.9.1.156-159.2002. PMC 119894. PMID 11777846.
- ^ a b c La Scola B, Fenollar F, Fournier PE, Altwegg M, Mallet MN, Raoult D; Fenollar; Fournier; Altwegg; Mallet; Raoult (July 2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". Int. J. Syst. Evol. Microbiol. 51 (Pt 4): 1471–9. PMID 11491348.
- ^ Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues". Johns Hopkins Hosp Bull 18: 382–91.
- ^ From Greek τροφή trophê, "nourishment, food" and ἔρυμα eruma, "fence, a defence against, barrier".
- ^ Relman D, Schmidt T, MacDermott R, Falkow S; Schmidt; MacDermott; Falkow (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med 327 (5): 293–301. doi:10.1056/NEJM199207303270501. PMID 1377787.
- ^ Raoult D, et al. (2003). "Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome". Genome Res 13 (8): 1800–9. doi:10.1101/gr.1474603 (inactive 2015-02-01). PMC 403771. PMID 12902375.
- ^ Bentley, SD.; Maiwald, M.; Murphy, LD.; Pallen, MJ.; Yeats, CA.; Dover, LG.; Norbertczak, HT.; Besra, GS.; et al. (Feb 2003). "Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei". Lancet 361 (9358): 637–44. doi:10.1016/S0140-6736(03)12597-4. PMID 12606174.
Gram-positive bacterial infection: Actinobacteria (primarily A00–A79, 001–041, 080–109)
|
|
Actinomycineae |
Actinomycetaceae |
- Actinomyces israelii
- Actinomycosis
- Cutaneous actinomycosis
- Tropheryma whipplei
- Arcanobacterium haemolyticum
- Arcanobacterium haemolyticum infection
- Actinomyces gerencseriae
|
|
Propionibacteriaceae |
|
|
|
Corynebacterineae |
Mycobacteriaceae |
M. tuberculosis/
M. bovis |
- Tuberculosis: Ghon focus/Ghon's complex
- Pott disease
- brain
- Tuberculous lymphadenitis
- Tuberculous cervical lymphadenitis
- cutaneous
- Scrofuloderma
- Erythema induratum
- Lupus vulgaris
- Prosector's wart
- Tuberculosis cutis orificialis
- Tuberculous cellulitis
- Tuberculous gumma
- Lichen scrofulosorum
- Tuberculid
- Papulonecrotic tuberculid
- Primary inoculation tuberculosis
- Miliary
- Tuberculous pericarditis
- Urogenital tuberculosis
- Multi-drug-resistant tuberculosis
- Extensively drug-resistant tuberculosis
|
|
M. leprae |
- Leprosy: Tuberculoid leprosy
- Borderline tuberculoid leprosy
- Borderline leprosy
- Borderline lepromatous leprosy
- Lepromatous leprosy
- Histoid leprosy
|
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Nontuberculous |
R1: |
|
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R2: |
|
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R3: |
- M. avium complex/Mycobacterium avium/Mycobacterium intracellulare/MAP
- M. ulcerans
- M. haemophilum
|
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R4/RG: |
- M. fortuitum
- M. chelonae
- M. abscessus
|
|
|
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Nocardiaceae |
- Nocardia asteroides/Nocardia brasiliensis
- Rhodococcus equi
|
|
Corynebacteriaceae |
- Corynebacterium diphtheriae
- Corynebacterium minutissimum
- Corynebacterium jeikeium
- Group JK corynebacterium sepsis
|
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Bifidobacteriaceae |
|
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UpToDate Contents
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English Journal
- Relapsing Whipple's disease: a case report and literature review.
- Ruggiero E1, Zurlo A, Giantin V, Galeazzi F, Mescoli C, Nante G, Petruzzellis F, Manzato E.
- European journal of gastroenterology & hepatology.Eur J Gastroenterol Hepatol.2015 Dec 8. [Epub ahead of print]
- Whipple's disease is a rare infection caused by Tropheryma whipplei, a Gram-negative Bacillus usually found in macrophages of the lamina propria of the small intestine. The typical clinical manifestations of classic Whipple's disease are diarrhea, weight loss, malabsorption, abdominal pain, and arth
- PMID 26649803
- Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma.
- Simpson JL1, Daly J2, Baines KJ3, Yang IA4, Upham JW5, Reynolds PN6, Hodge S6, James AL7, Hugenholtz P2, Willner D2, Gibson PG8.
- The European respiratory journal.Eur Respir J.2015 Dec 2. pii: ERJ-00405-2015. doi: 10.1183/13993003.00405-2015. [Epub ahead of print]
- Asthma is a chronic inflammatory disorder of the airways where bacteria may act as protagonists of chronic inflammation. Little is known about the relation of airway inflammation to the presence of specific bacterial taxa. We sought to describe the sputum microbiome in adults with poorly controlled
- PMID 26647445
- Tropheryma whipplei Endocarditis: A Two-patient Case Series.
- Borne RT1, Babu A2, Levi M3, Brieke A1, Quaife RA4.
- The American journal of medicine.Am J Med.2015 Dec;128(12):1364-6. doi: 10.1016/j.amjmed.2015.06.053. Epub 2015 Jul 31.
- BACKGROUND: Whipple endocarditis is caused by Tropheryma whipplei and is a well-described complication of Whipple's disease. Limited and small case series have been published regarding the presentation, diagnosis, and clinical course of this disease.METHODS/RESULTS: We describe 2 cases of patients w
- PMID 26239095
Japanese Journal
- 電子顕微鏡所見とPCR法で確診したWhipple病の1例
- Whipple Disease Diagnosed with PCR Using Formalin-fixed Paraffin-embedded Specimens of the Intestinal Mucosa
- Central Nervous System Relapse of Whipple's Disease
Related Links
- Tropheryma whipplei is rod shaped, a gram-postive bacterium (5). It was finally isolated in eukaryotic cells in the year 2000 and propagated in culture at thirty-seven degrees Celsius, but was believed to resist culturing for a long time ...
- 1. Clin Microbiol Rev. 2001 Jul;14(3):561-83. Whipple's disease and "Tropheryma whippelii". Dutly F, Altwegg M. Whipple's disease is a rare bacterial infection that may involve any organ system in the body. It occurs primarily in ...
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