関: fibrin tissue adhesive

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/11 00:29:43」(JST)

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Fibrin glue applied after drying the scleral bed in an intraocular lens operation

Fibrin glue (also called fibrin sealant) is a formulation used to create a fibrin clot.^[1]^[2]^[3]^[4]^[5]^[6]^[7] It is made up of fibrinogen (lyophilised pooled human concentrate) and thrombin (bovine, which is reconstituted with calcium chloride)^[1] that are applied to the tissue sites to glue them together.^[1] Thrombin is an enzyme and converts fibrinogen into fibrin monomers between 10 and 60 seconds giving rise to a three-dimensional gel.^[6]^[8]

Factors that influence dimensional structure of fibrin gel giving rise to fine or coarse gel

Changing concentration of fibrinogen
Changing concentration of thrombine- increase concentration increases ultimate tensile strength and youngs modulus of gel
Changing concentration of calcium
pH
Temperature

It may also contain aprotinin, fibronectin and plasminogen.^[9] This glue can be used for repairing dura tears, bronchial fistulas and for achieving hemostasis after spleen and liver trauma.^[6] It is also employed in "no sutures" corneal transplantation, pterygium excision with amniotic membrane or conjunctival autograft, and in ocular trauma for corneal or conjunctival defects.^[10]^[11]

References

^ ^a ^b ^c http://www.bmj.com/cgi/content/extract/308/6934/933
^ http://www.theannals.com/cgi/content/abstract/22/12/946
^ http://www.medhelp.org/forums/gastro/archive/1054.html
^ http://content.karger.com/ProdukteDB/produkte.asp?Doi=8552
^ http://www.healthsystem.virginia.edu/internet/stac/research/spfibgl.cfm
^ ^a ^b ^c http://www.ijps.org/article.asp?issn=0970-0358;year=2003;volume=36;issue=1;spage=14;epage=17;aulast=Saxena
^ http://www3.interscience.wiley.com/journal/121466570/abstract
^ Spotnitz, W. . (2009). "Fibrin Sealant: Past, Present, and Future: A Brief Review". World journal of surgery 34 (4): 632–634. doi:10.1007/s00268-009-0252-7. PMID 19820991. edit
^ Tisseel From the Swedish official drug catalog
^ Narendran N, Mohamed S, Shah S (July 2007). "No sutures corneal grafting--a novel use of overlay sutures and fibrin glue in Deep Anterior Lamellar Keratoplasty". Cont Lens Anterior Eye 30 (3): 207–9. doi:10.1016/j.clae.2007.02.007. PMID 17379570.
^ Dal Pizzol, MM; Roggia, MF; Kwitko, S; Marinho, DR; Rymer, S (2009). "Use of fibrin glue in ocular surgery". Arquivos brasileiros de oftalmologia 72 (3): 308–12. PMID 19668958. edit

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1. 手術室で使用される局所止血剤および組織接着剤の概要 overview of topical hemostatic agents and tissues adhesives used in the operating room
2. フィブリンシーラント fibrin sealant
3. フィブリノゲンの異常 disorders of fibrinogen
4. 婦人科外科手術における出血のマネージメント management of hemorrhage in gynecologic surgery

English Journal

A comparative study of the regenerative effect of sinus bone grafting with platelet-rich fibrin-mixed Bio-Oss(®) and commercial fibrin-mixed Bio-Oss(®): An experimental study.

Xuan F1, Lee CU1, Son JS1, Jeong SM1, Choi BH2.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.J Craniomaxillofac Surg.2014 Jun;42(4):e47-50. doi: 10.1016/j.jcms.2013.05.029. Epub 2013 Aug 2.
Anorganic bovine bone (Bio-Oss(®)) particles are one of the most popular grafting materials. The particles are often mixed with platelet-rich fibrin (PRF) or a commercial fibrin (Tisseel(®)) to form a mouldable graft material. The objective of this study was to compare the potentials of PRF-mixed
PMID 23911120

Quilting sutures, fibrin tissue adhesive or both in reducing the incidence of seroma in the latissimus dorsi flap donor site? An evidence-based analysis.

Cheng HT1, Hsu YC2, Wu CI2.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS.J Plast Reconstr Aesthet Surg.2014 Jun;67(6):881-2. doi: 10.1016/j.bjps.2013.12.042. Epub 2014 Jan 4.
PMID 24439215

Characterization of Mechanics and Cytocompatibility of Fibrin-Genipin Annulus Fibrosus Sealant with the Addition of Cell Adhesion Molecules.

Guterl CC1, Torre OM, Purmessur D, Dave K, Likhitpanichkul M, Hecht AC, Nicoll SB, Iatridis JC.
Tissue engineering. Part A.Tissue Eng Part A.2014 May 6. [Epub ahead of print]
There is an unmet clinical need for a biomaterial sealant capable of repairing small annulus fibrosus (AF) defects. Causes of these defects include painful intervertebral disc herniations, microdiscectomy procedures, morbidity associated with needle puncture injury from discography, and future nucle
PMID 24684314

Japanese Journal

フィブリン接着剤を用いた膝前十字靱帯固定術後の理学療法

木村典代,熊崎大輔,谷埜予士次 [他]
関西理学療法 5, 137-141, 2005-00-00
NAID 40007307993

Controlled survival study of the effects of Tisseel or a combination of FloSeal and Tisseel on major vascular injury and major collecting-system injury during partial nephrectomy in a porcine model

L'ESPERANCE JO
J Endourol 19, 1114-1121, 2005
NAID 30018213924

Biochemical characterization of autologous fibrin sealants produced by CryoSeal^( !R) and Vivostat^( !R) in comparison to the homologous fibrin sealant product Tissucol/Tisseel^( !R)

BUCHTA C
Biomaterials 26, 6233-6241, 2005
NAID 30003054922

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