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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/06 21:14:23」(JST)

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TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.^[1]

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.^[2]

Interactions

TRAF5 has been shown to interact with ASK1,^[3]^[4] TNFRSF13B,^[5] CD134,^[6] CD30,^[7] CD40,^[8]^[9] RANK^[10]^[11]^[12] and TNFRSF14.^[13]^[14]

References

^ Tang XX, Pleasure DE, Ikegaki N (May 1997). "cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors". Genomics 41 (1): 17–24. doi:10.1006/geno.1997.4615. PMID 9126477.
^ "Entrez Gene: TRAF5 TNF receptor-associated factor 5".
^ Nishitoh, H; Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell (UNITED STATES) 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. ISSN 1097-2765. PMID 9774977. Cite uses deprecated parameters (help)
^ Hoeflich, K P; Yeh W C, Yao Z, Mak T W, Woodgett J R (October 1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)". Oncogene (ENGLAND) 18 (42): 5814–20. doi:10.1038/sj.onc.1202975. ISSN 0950-9232. PMID 10523862. Cite uses deprecated parameters (help)
^ Xia, X Z; Treanor J, Senaldi G, Khare S D, Boone T, Kelley M, Theill L E, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng S Y, Boyle W J, Hsu H (July 2000). "Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation". J. Exp. Med. (UNITED STATES) 192 (1): 137–43. doi:10.1084/jem.192.1.137. ISSN 0022-1007. PMC 1887716. PMID 10880535. Cite uses deprecated parameters (help)
^ Kawamata, S; Hori T, Imura A, Takaori-Kondo A, Uchiyama T (March 1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation". J. Biol. Chem. (UNITED STATES) 273 (10): 5808–14. doi:10.1074/jbc.273.10.5808. ISSN 0021-9258. PMID 9488716. Cite uses deprecated parameters (help)
^ Aizawa, S; Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (January 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. (UNITED STATES) 272 (4): 2042–5. doi:10.1074/jbc.272.4.2042. ISSN 0021-9258. PMID 8999898. Cite uses deprecated parameters (help)
^ Tsukamoto, N; Kobayashi N, Azuma S, Yamamoto T, Inoue J (February 1999). "Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. ISSN 0027-8424. PMC 15446. PMID 9990007. Cite uses deprecated parameters (help)
^ Ishida, T K; Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J (September 1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (18): 9437–42. doi:10.1073/pnas.93.18.9437. ISSN 0027-8424. PMC 38446. PMID 8790348. Cite uses deprecated parameters (help)
^ Darnay, B G; Haridas V, Ni J, Moore P A, Aggarwal B B (August 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". J. Biol. Chem. (UNITED STATES) 273 (32): 20551–5. doi:10.1074/jbc.273.32.20551. ISSN 0021-9258. PMID 9685412. Cite uses deprecated parameters (help)
^ Darnay, B G; Ni J, Moore P A, Aggarwal B B (March 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". J. Biol. Chem. (UNITED STATES) 274 (12): 7724–31. doi:10.1074/jbc.274.12.7724. ISSN 0021-9258. PMID 10075662. Cite uses deprecated parameters (help)
^ Galibert, L; Tometsko M E, Anderson D M, Cosman D, Dougall W C (December 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. (UNITED STATES) 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. ISSN 0021-9258. PMID 9852070. Cite uses deprecated parameters (help)
^ Hsu, H; Solovyev I, Colombero A, Elliott R, Kelley M, Boyle W J (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". J. Biol. Chem. (UNITED STATES) 272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. ISSN 0021-9258. PMID 9153189. Cite uses deprecated parameters (help)
^ Marsters, S A; Ayres T M, Skubatch M, Gray C L, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022. Cite uses deprecated parameters (help)

UpToDate Contents

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English Journal

MiR-26b inhibits melanoma cell proliferation and enhances apoptosis by suppressing TRAF5-mediated MAPK activation.

Li M1, Long C1, Yang G1, Luo Y1, Du H2.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Mar 11;471(3):361-7. doi: 10.1016/j.bbrc.2016.02.021. Epub 2016 Feb 10.
Alterations in microRNA-26b (miR-26b) expression have been shown to participate in various malignant tumor developments. However, the possible function of miR-26b in human melanoma cells remains unclarified. In this study, quantitative polymerase chain reaction was used to explore the expression pro
PMID 26872428

Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.

Kutilek VD1, Andrews CL2, Richards MP2, Xu Z2, Sun T2, Chen Y2, Hashke A2, Smotrov N2, Fernandez R2, Nickbarg EB2, Chamberlin C2, Sauvagnat B2, Curran PJ2, Boinay R2, Saradjian P2, Allen SJ2, Byrne N2, Elsen NL3, Ford RE2, Hall DL2, Kornienko M2, Rickert KW4, Sharma S2, Shipman JM2, Lumb KJ2, Coleman K5, Dandliker PJ2, Kariv I2, Beutel B2.
Journal of biomolecular screening.J Biomol Screen.2016 Mar 11. pii: 1087057116637353. [Epub ahead of print]
The primary objective of early drug discovery is to associate druggable target space with a desired phenotype. The inability to efficiently associate these often leads to failure early in the drug discovery process. In this proof-of-concept study, the most tractable starting points for drug discover
PMID 26969322

TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classical IKK complex in hematopoietic cells.

Zhang L1, Blackwell K1, Workman LM1, Gibson-Corley KN1, Olivier AK1, Bishop GA2, Habelhah H3.
Journal of cell science.J Cell Sci.2016 Feb 12. pii: jcs.180554. [Epub ahead of print]
The role of TRAF2 and TRAF5 in TNFα-induced NF-κB activation has become complicated due to accumulation of conflicting data. Here, we report that 7-day old TRAF2 knockout (KO) and TRAF2/TRAF5 double KO (TRAF2/5 DKO) mice exhibit enhanced canonical IKK and caspase-8 activation in spleen and liver,
PMID 26872784

Japanese Journal

TRAF5はIL-6シグナルを制御することでT[H]17分化を抑制する

臨床免疫・アレルギー科 63(4), 396-400, 2015-04
NAID 40020445095

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death

J Biol Chem 276, 36530-36534, 2001
NAID 80012645381

Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

Proc. Natl Acad. Sci. USA 96, 9803, 1999
NAID 30016229736

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★リンクテーブル★

リンク元	「TNF受容体関連因子5」「TNF receptor-associated factor 5」
関連記事	「TRAF」

「TNF受容体関連因子5」

TNF receptor-associated factor 5
Identifiers
Symbols	TRAF5 ; MGC:39780; RNF84
External IDs	OMIM: 602356 HomoloGene: 27079 GeneCards: TRAF5 Gene
Gene ontology
Molecular function	• ubiquitin-protein ligase activity; • signal transducer activity; • protein binding; • zinc ion binding; • ubiquitin protein ligase binding; • thioesterase binding;
Cellular component	• cytoplasm; • centrosome; • internal side of plasma membrane; • CD40 receptor complex;
Biological process	• apoptotic process; • signal transduction; • positive regulation of cell proliferation; • regulation of apoptotic process; • positive regulation of I-kappaB kinase/NF-kappaB cascade; • positive regulation of sequence-specific DNA binding transcription factor activity; • positive regulation of NF-kappaB transcription factor activity;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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