TNF受容体関連因子2

関: TNF receptor-associated factor 2

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/20 18:59:17」(JST)

wiki en

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.^[1]

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms complexes with other TRAF proteins. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. cIAP1 can ubiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.^[2]

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

Interactions

TRAF2 has been shown to interact with BCL10,^[3] CD30,^[4]^[5] CFLAR,^[6]^[7] IKK2,^[8]^[9] MAP3K7IP2,^[9]^[10] CD137,^[11]^[12] Caveolin 1,^[13]^[14] CD27,^[15]^[16] TNFRSF13B,^[17] TANK-binding kinase 1,^[18]^[19] TRAF1,^[18]^[20] CD40,^[21]^[22]^[23] UBE2N,^[24] MAP3K14,^[23]^[25] MAP4K2,^[26] CASP8AP2,^[27] HIVEP3,^[28] TNFAIP3,^[29] TNFRSF1B,^[1]^[18]^[20]^[30]^[31]^[32]^[33] TNFRSF1A,^[34]^[35]^[36] SPHK1,^[37] Low affinity nerve growth factor receptor,^[38] TNFRSF14,^[32]^[39] CHUK,^[8]^[9]^[40] CD134,^[12] EDARADD,^[41] RIPK1,^[20]^[23]^[34]^[42] RANK,^[43]^[44]^[45]^[46] TNFSF14,^[47] TANK,^[18]^[31]^[48]^[49] Baculoviral IAP repeat-containing protein 3,^[3]^[50]^[51]^[52] BIRC2,^[3]^[36]^[50]^[51]^[52]^[53] MAP4K5,^[54] ASK1,^[55]^[56]^[57] TRADD,^[18]^[20]^[23]^[35]^[42]^[58]^[59] MAP3K1^[60] and TRAF interacting protein.^[61]

References

^ ^a ^b Song HY, Donner DB (September 1995). "Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor". Biochem J. 309 ( Pt 3) (Pt 3): 825–9. PMC 1135706. PMID 7639698.
^ "Entrez Gene: TRAF2 TNF receptor-associated factor 2".
^ ^a ^b ^c Yoneda, T; Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. (UNITED STATES) 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. ISSN 0021-9258. PMID 10753917. Cite uses deprecated parameters (help)
^ Aizawa, S; Nakano H; Ishida T; Horie R; Nagai M; Ito K; Yagita H; Okumura K; Inoue J; Watanabe T (January 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. (UNITED STATES) 272 (4): 2042–5. doi:10.1074/jbc.272.4.2042. ISSN 0021-9258. PMID 8999898.
^ Ansieau, S; Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss H J (November 1996). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (24): 14053–8. doi:10.1073/pnas.93.24.14053. ISSN 0027-8424. PMC 19493. PMID 9411448. Cite uses deprecated parameters (help) (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
^ Shu, H B; Halpin D R; Goeddel D V (June 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity (UNITED STATES) 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. ISSN 1074-7613. PMID 9208847.
^ Kataoka, T; Budd R C, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J (June 2000). "The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways". Curr. Biol. (ENGLAND) 10 (11): 640–8. doi:10.1016/S0960-9822(00)00512-1. ISSN 0960-9822. PMID 10837247. Cite uses deprecated parameters (help)
^ ^a ^b Devin, A; Lin Y; Yamaoka S; Li Z; Karin M; Liu Zg (June 2001). "The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF". Mol. Cell. Biol. (United States) 21 (12): 3986–94. doi:10.1128/MCB.21.12.3986-3994.2001. ISSN 0270-7306. PMC 87061. PMID 11359906.
^ ^a ^b ^c Li, Shitao; Wang Lingyan; Dorf Martin E (January 2009). "PKC phosphorylation of TRAF2 mediates IKKα/β recruitment and K63-linked polyubiquitination". Mol. Cell (United States) 33 (1): 30–42. doi:10.1016/j.molcel.2008.11.023. PMC 2643372. PMID 19150425.
^ Takaesu, G; Kishida S; Hiyama A; Yamaguchi K; Shibuya H; Irie K; Ninomiya-Tsuji J; Matsumoto K (April 2000). "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". Mol. Cell (UNITED STATES) 5 (4): 649–58. doi:10.1016/S1097-2765(00)80244-0. ISSN 1097-2765. PMID 10882101.
^ Jang, I K; Lee Z H; Kim Y J; Kim S H; Kwon B S (January 1998). "Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B". Biochem. Biophys. Res. Commun. (UNITED STATES) 242 (3): 613–20. doi:10.1006/bbrc.1997.8016. ISSN 0006-291X. PMID 9464265.
^ ^a ^b Arch, R H; Thompson C B (January 1998). "4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB". Mol. Cell. Biol. (UNITED STATES) 18 (1): 558–65. ISSN 0270-7306. PMC 121523. PMID 9418902.
^ Feng, X; Gaeta M L; Madge L A; Yang J H; Bradley J R; Pober J S (March 2001). "Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors". J. Biol. Chem. (United States) 276 (11): 8341–9. doi:10.1074/jbc.M007116200. ISSN 0021-9258. PMID 11112773.
^ Cao, Haiming; Courchesne William E; Mastick Cynthia Corley (March 2002). "A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase". J. Biol. Chem. (United States) 277 (11): 8771–4. doi:10.1074/jbc.C100661200. ISSN 0021-9258. PMID 11805080.
^ Yamamoto, H; Kishimoto T; Minamoto S (November 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". J. Immunol. (UNITED STATES) 161 (9): 4753–9. ISSN 0022-1767. PMID 9794406.
^ Akiba, H; Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware C F, Malinin N L, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. ISSN 0021-9258. PMID 9582383. Cite uses deprecated parameters (help)
^ Xia, X Z; Treanor J, Senaldi G, Khare S D, Boone T, Kelley M, Theill L E, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng S Y, Boyle W J, Hsu H (July 2000). "Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation". J. Exp. Med. (UNITED STATES) 192 (1): 137–43. doi:10.1084/jem.192.1.137. ISSN 0022-1007. PMC 1887716. PMID 10880535. Cite uses deprecated parameters (help)
^ ^a ^b ^c ^d ^e Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. Cite uses deprecated parameters (help)
^ Bonnard, M; Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itié A, Wakeham A, Shahinian A, Henzel W J, Elia A J, Shillinglaw W, Mak T W, Cao Z, Yeh W C (September 2000). "Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcription". EMBO J. (ENGLAND) 19 (18): 4976–85. doi:10.1093/emboj/19.18.4976. ISSN 0261-4189. PMC 314216. PMID 10990461. Cite uses deprecated parameters (help)
^ ^a ^b ^c ^d Takeuchi, M; Rothe M; Goeddel D V (August 1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. (UNITED STATES) 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. ISSN 0021-9258. PMID 8702708.
^ McWhirter, S M; Pullen S S; Holton J M; Crute J J; Kehry M R; Alber T (July 1999). "Crystallographic analysis of CD40 recognition and signaling by human TRAF2". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (15): 8408–13. doi:10.1073/pnas.96.15.8408. ISSN 0027-8424. PMC 17529. PMID 10411888.
^ Tsukamoto, N; Kobayashi N; Azuma S; Yamamoto T; Inoue J (February 1999). "Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. ISSN 0027-8424. PMC 15446. PMID 9990007.
^ ^a ^b ^c ^d Malinin, N L; Boldin M P; Kovalenko A V; Wallach D (February 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature (ENGLAND) 385 (6616): 540–4. doi:10.1038/385540a0. ISSN 0028-0836. PMID 9020361.
^ Deng, L; Wang C; Spencer E; Yang L; Braun A; You J; Slaughter C; Pickart C; Chen Z J (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain". Cell (UNITED STATES) 103 (2): 351–61. doi:10.1016/S0092-8674(00)00126-4. ISSN 0092-8674. PMID 11057907.
^ Luftig, M A; Cahir-McFarland E; Mosialos G; Kieff E (May 2001). "Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". J. Biol. Chem. (United States) 276 (18): 14602–6. doi:10.1074/jbc.C100103200. ISSN 0021-9258. PMID 11278268.
^ Yuasa, T; Ohno S; Kehrl J H; Kyriakis J M (August 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". J. Biol. Chem. (UNITED STATES) 273 (35): 22681–92. doi:10.1074/jbc.273.35.22681. ISSN 0021-9258. PMID 9712898.
^ Choi, Y H; Kim K B, Kim H H, Hong G S, Kwon Y K, Chung C W, Park Y M, Shen Z J, Kim B J, Lee S Y, Jung Y K (July 2001). "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. (United States) 276 (27): 25073–7. doi:10.1074/jbc.M102941200. ISSN 0021-9258. PMID 11340079. Cite uses deprecated parameters (help)
^ Oukka, Mohamed; Kim Sean T; Lugo Geancarlo; Sun Jenny; Wu Lai-Chu; Glimcher Laurie H (January 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Mol. Cell (United States) 9 (1): 121–31. doi:10.1016/S1097-2765(01)00434-8. ISSN 1097-2765. PMID 11804591.
^ Song, H Y; Rothe M; Goeddel D V (June 1996). "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6721–5. doi:10.1073/pnas.93.13.6721. ISSN 0027-8424. PMC 39093. PMID 8692885.
^ Hostager, Bruce S; Bishop Gail A (April 2002). "Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b". J. Immunol. (United States) 168 (7): 3318–22. doi:10.4049/jimmunol.168.7.3318. ISSN 0022-1767. PMID 11907088.
^ ^a ^b Rothe, M; Xiong J; Shu H B; Williamson K; Goddard A; Goeddel D V (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. ISSN 0027-8424. PMC 38654. PMID 8710854.
^ ^a ^b Marsters, S A; Ayres T M; Skubatch M; Gray C L; Rothe M; Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022.
^ Carpentier, Isabelle; Coornaert Beatrice; Beyaert Rudi (October 2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation". Biochem. Biophys. Res. Commun. (United States) 374 (4): 752–7. doi:10.1016/j.bbrc.2008.07.103. PMID 18671942.
^ ^a ^b Hsu, H; Huang J; Shu H B; Baichwal V; Goeddel D V (April 1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity (UNITED STATES) 4 (4): 387–96. doi:10.1016/S1074-7613(00)80252-6. ISSN 1074-7613. PMID 8612133.
^ ^a ^b Hsu, H; Shu H B; Pan M G; Goeddel D V (January 1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell (UNITED STATES) 84 (2): 299–308. doi:10.1016/S0092-8674(00)80984-8. ISSN 0092-8674. PMID 8565075.
^ ^a ^b Shu, H B; Takeuchi M; Goeddel D V (November 1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. ISSN 0027-8424. PMC 19479. PMID 8943045.
^ Xia, Pu; Wang Lijun, Moretti Paul A B, Albanese Nathaniel, Chai Fugui, Pitson Stuart M, D'Andrea Richard J, Gamble Jennifer R, Vadas Mathew A (March 2002). "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". J. Biol. Chem. (United States) 277 (10): 7996–8003. doi:10.1074/jbc.M111423200. ISSN 0021-9258. PMID 11777919. Cite uses deprecated parameters (help)
^ Ye, X; Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang J J, Leo E, Zapata J, Hauser C A, Reed J C, Bredesen D E (October 1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. (UNITED STATES) 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. ISSN 0021-9258. PMID 10514511. Cite uses deprecated parameters (help)
^ Hsu, H; Solovyev I; Colombero A; Elliott R; Kelley M; Boyle W J (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". J. Biol. Chem. (UNITED STATES) 272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. ISSN 0021-9258. PMID 9153189.
^ Régnier, C H; Song H Y; Gao X; Goeddel D V; Cao Z; Rothe M (July 1997). "Identification and characterization of an IkappaB kinase". Cell (UNITED STATES) 90 (2): 373–83. doi:10.1016/S0092-8674(00)80344-X. ISSN 0092-8674. PMID 9244310.
^ Yan, Minhong; Zhang Zemin; Brady John Ridgway; Schilbach Sarah; Fairbrother Wayne J; Dixit Vishva M (March 2002). "Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice". Curr. Biol. (England) 12 (5): 409–13. doi:10.1016/S0960-9822(02)00687-5. ISSN 0960-9822. PMID 11882293.
^ ^a ^b Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (September 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302. Cite uses deprecated parameters (help)
^ Darnay, B G; Haridas V; Ni J; Moore P A; Aggarwal B B (August 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". J. Biol. Chem. (UNITED STATES) 273 (32): 20551–5. doi:10.1074/jbc.273.32.20551. ISSN 0021-9258. PMID 9685412.
^ Darnay, B G; Ni J; Moore P A; Aggarwal B B (March 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". J. Biol. Chem. (UNITED STATES) 274 (12): 7724–31. doi:10.1074/jbc.274.12.7724. ISSN 0021-9258. PMID 10075662.
^ Galibert, L; Tometsko M E; Anderson D M; Cosman D; Dougall W C (Dec 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. (UNITED STATES) 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. ISSN 0021-9258. PMID 9852070.
^ Kim, H H; Lee D E; Shin J N; Lee Y S; Jeon Y M; Chung C H; Ni J; Kwon B S; Lee Z H (January 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Lett. (NETHERLANDS) 443 (3): 297–302. doi:10.1016/S0014-5793(98)01731-1. ISSN 0014-5793. PMID 10025951.
^ Kuai, Jun; Nickbarg Elliott; Wooters Joe; Qiu Yongchang; Wang Jack; Lin Lih-Ling (April 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. (United States) 278 (16): 14363–9. doi:10.1074/jbc.M208672200. ISSN 0021-9258. PMID 12571250.
^ Nomura, F; Kawai T; Nakanishi K; Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes Cells (ENGLAND) 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. ISSN 1356-9597. PMID 10759890.
^ Pomerantz, J L; Baltimore D (Dec 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". EMBO J. (ENGLAND) 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. ISSN 0261-4189. PMC 1171732. PMID 10581243.
^ ^a ^b Uren, A G; Pakusch M; Hawkins C J; Puls K L; Vaux D L (May 1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (10): 4974–8. doi:10.1073/pnas.93.10.4974. ISSN 0027-8424. PMC 39390. PMID 8643514.
^ ^a ^b Roy, N; Deveraux Q L; Takahashi R; Salvesen G S; Reed J C (Dec 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. (ENGLAND) 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. ISSN 0261-4189. PMC 1170295. PMID 9384571.
^ ^a ^b Li, Xiaoming; Yang Yili; Ashwell Jonathan D (March 2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature (England) 416 (6878): 345–7. doi:10.1038/416345a. ISSN 0028-0836. PMID 11907583.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Cite uses deprecated parameters (help)
^ Shi, C S; Leonardi A; Kyriakis J; Siebenlist U; Kehrl J H (September 1999). "TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related". J. Immunol. (UNITED STATES) 163 (6): 3279–85. ISSN 0022-1767. PMID 10477597.
^ Nishitoh, H; Saitoh M; Mochida Y; Takeda K; Nakano H; Rothe M; Miyazono K; Ichijo H (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell (UNITED STATES) 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. ISSN 1097-2765. PMID 9774977.
^ Hoeflich, K P; Yeh W C; Yao Z; Mak T W; Woodgett J R (October 1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)". Oncogene (ENGLAND) 18 (42): 5814–20. doi:10.1038/sj.onc.1202975. ISSN 0950-9232. PMID 10523862.
^ Gan, Boyi; Peng Xu; Nagy Tamas; Alcaraz Ana; Gu Hua; Guan Jun-Lin (October 2006). "Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways". J. Cell Biol. (United States) 175 (1): 121–33. doi:10.1083/jcb.200604129. ISSN 0021-9525. PMC 2064504. PMID 17015619.
^ Park, Y C; Ye H; Hsia C; Segal D; Rich R L; Liou H C; Myszka D G; Wu H (June 2000). "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction". Cell (UNITED STATES) 101 (7): 777–87. doi:10.1016/S0092-8674(00)80889-2. ISSN 0092-8674. PMID 10892748.
^ Tsao, D H; McDonagh T; Telliez J B; Hsu S; Malakian K; Xu G Y; Lin L L (June 2000). "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway". Mol. Cell (UNITED STATES) 5 (6): 1051–7. doi:10.1016/S1097-2765(00)80270-1. ISSN 1097-2765. PMID 10911999.
^ Baud, V; Liu Z G; Bennett B; Suzuki N; Xia Y; Karin M (May 1999). "Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain". Genes Dev. (UNITED STATES) 13 (10): 1297–308. doi:10.1101/gad.13.10.1297. ISSN 0890-9369. PMC 316725. PMID 10346818.
^ Lee, S Y; Lee S Y; Choi Y (April 1997). "TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation". J. Exp. Med. (UNITED STATES) 185 (7): 1275–85. doi:10.1084/jem.185.7.1275. ISSN 0022-1007. PMC 2196258. PMID 9104814.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. エプスタインバーウイルス（EBウイルス）のウイルス学 virology of epstein barr virus
2. 原発性縦隔大細胞型B細胞リンパ腫 primary mediastinal large b cell lymphoma
3. 関節リウマチにおけるHLAおよびその他の感受性遺伝子 hla and other susceptibility genes in rheumatoid arthritis
4. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy
5. びまん性大細胞型B細胞性リンパ腫および原発性縦隔大細胞型B細胞リンパ腫の病理学 pathobiology of diffuse large b cell lymphoma and primary mediastinal large b cell lymphoma

English Journal

A systematic review of p53 regulation of oxidative stress in skeletal muscle.

Beyfuss K1, Hood DA1.
Redox report : communications in free radical research.Redox Rep.2018 Dec;23(1):100-117. doi: 10.1080/13510002.2017.1416773. Epub 2018 Jan 3.
PMID 29298131

RACK1/TRAF2 regulation of modulator of apoptosis-1 (MOAP-1).

Law J1, Kwek I1, Svystun O1, Lim J1, Tan CT2, Luong L1, Yu VC2, Baksh S3.
Biochimica et biophysica acta.Biochim Biophys Acta.2018 May;1865(5):684-694. doi: 10.1016/j.bbamcr.2018.02.006. Epub 2018 Feb 19.
PMID 29470995

CDCA3 promotes cell proliferation by activating the NF-κB/cyclin D1 signaling pathway in colorectal cancer.

Zhang W1, Lu Y1, Li X1, Zhang J2, Zheng L1, Zhang W1, Lin C1, Lin W1, Li X3.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2018 Apr 5. pii: S0006-291X(18)30797-6. doi: 10.1016/j.bbrc.2018.04.034. [Epub ahead of print]
PMID 29627567

Japanese Journal

14-3-3 Protein Protects Against Cardiac Endoplasmic Reticulum Stress (ERS) and ERS-Initiated Apoptosis in Experimental Diabetes

Sari Flori R.,Watanabe Kenichi,Thandavarayan Rajarajan A.,Harima Meilei,Zhang Shaosong,Muslin Anthony J.,Kodama Makoto,Aizawa Yoshifusa
Journal of Pharmacological Sciences advpub(0), 1007120415, 2010
… In conclusion, partial depletion of 14-3-3 protein in the diabetic heart exacerbates cardiac ERS and activates ERS-induced apoptosis pathways, at least in part, through the regulation of CHOP and caspase-12 via the Ire1α/TRAF2 pathway. …
NAID 130000301209

TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40

JABARA Haifa H.,WENG Yu,SANNIKOVA Tatyana,GEHA Raif S.
International immunology 21(4), 447-488, 2009-04-01
NAID 10025385817

Related Pictures

Oncogene - Figure 1 for article: Ubiquitin FIGURE 3 | IAPs function as E3 ligases in S1P与TRAF2的结合模式图，TRAF2 www.biomedcentral.com - Figure Tumor necrosis factor alpha - Wikipedia The role of TRAF2 phosphorylation in RANKL gp130はインターロイキン6および

★リンクテーブル★

リンク元	「TNF受容体関連因子2」「TNF receptor-associated factor 2」
関連記事	「TRAF」

「TNF受容体関連因子2」

TNF receptor-associated factor 2
	; PDB rendering based on 1ca4.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1CA4, 1CA9, 1CZY, 1CZZ, 1D00, 1D01, 1D0A, 1D0J, 1F3V, 1QSC, 3KNV, 3M06, 3M0A, 3M0D
Identifiers
Symbols	TRAF2 ; MGC:45012; TRAP; TRAP3
External IDs	OMIM: 601895 MGI: 101835 HomoloGene: 22520 GeneCards: TRAF2 Gene
Gene ontology
Molecular function	• ubiquitin-protein transferase activity; • signal transducer activity; • tumor necrosis factor receptor binding; • CD40 receptor binding; • protein binding; • zinc ion binding; • ligase activity; • enzyme binding; • protein phosphatase binding; • mitogen-activated protein kinase kinase kinase binding; • ubiquitin protein ligase binding; • thioesterase binding; • protein complex binding; • identical protein binding; • sphingolipid binding;
Cellular component	• cytoplasm; • cytosol; • cell cortex; • cytoplasmic side of plasma membrane; • CD40 receptor complex; • membrane raft;
Biological process	• positive regulation of T cell cytokine production; • protein complex assembly; • apoptotic process; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • signal transduction; • activation of NF-kappaB-inducing kinase activity; • protein catabolic process; • positive regulation of interleukin-2 production; • tumor necrosis factor-mediated signaling pathway; • negative regulation of glial cell apoptotic process; • regulation of apoptotic process; • positive regulation of JUN kinase activity; • cellular protein complex assembly; • innate immune response; • positive regulation of T cell activation; • regulation of immunoglobulin secretion; • positive regulation of sequence-specific DNA binding transcription factor activity; • positive regulation of NF-kappaB transcription factor activity; • protein heterooligomerization; • protein autoubiquitination; • protein homotrimerization; • protein K63-linked ubiquitination; • positive regulation of protein homodimerization activity; • apoptotic signaling pathway; • positive regulation of extrinsic apoptotic signaling pathway; • regulation of extrinsic apoptotic signaling pathway in absence of ligand;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: TNF receptor-associated factor 2、TRAF2

「TNF receptor-associated factor 2」

　　[★]

TNF受容体関連因子2

関: TRAF2

「TRAF」

　　[★]

TNF受容体関連因子

関: TNF receptor-associated factor、tumor necrosis factor receptor-associated factor

[pmid7639698-1] Song HY, Donner DB (September 1995). "Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor". Biochem J. 309 ( Pt 3) (Pt 3): 825–9. PMC 1135706. PMID 7639698.

[2] "Entrez Gene: TRAF2 TNF receptor-associated factor 2".

[pmid10753917-3] Yoneda, T; Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. (UNITED STATES) 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. ISSN 0021-9258. PMID 10753917. Cite uses deprecated parameters (help)

[pmid8999898-4] Aizawa, S; Nakano H; Ishida T; Horie R; Nagai M; Ito K; Yagita H; Okumura K; Inoue J; Watanabe T (January 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. (UNITED STATES) 272 (4): 2042–5. doi:10.1074/jbc.272.4.2042. ISSN 0021-9258. PMID 8999898.

[pmid8943059-5] Ansieau, S; Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss H J (November 1996). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (24): 14053–8. doi:10.1073/pnas.93.24.14053. ISSN 0027-8424. PMC 19493. PMID 9411448. Cite uses deprecated parameters (help) (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)

[pmid9208847-6] Shu, H B; Halpin D R; Goeddel D V (June 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity (UNITED STATES) 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. ISSN 1074-7613. PMID 9208847.

[pmid10837247-7] Kataoka, T; Budd R C, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J (June 2000). "The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways". Curr. Biol. (ENGLAND) 10 (11): 640–8. doi:10.1016/S0960-9822(00)00512-1. ISSN 0960-9822. PMID 10837247. Cite uses deprecated parameters (help)

[pmid11359906-8] Devin, A; Lin Y; Yamaoka S; Li Z; Karin M; Liu Zg (June 2001). "The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF". Mol. Cell. Biol. (United States) 21 (12): 3986–94. doi:10.1128/MCB.21.12.3986-3994.2001. ISSN 0270-7306. PMC 87061. PMID 11359906.

[pmid19150425-9] Li, Shitao; Wang Lingyan; Dorf Martin E (January 2009). "PKC phosphorylation of TRAF2 mediates IKKα/β recruitment and K63-linked polyubiquitination". Mol. Cell (United States) 33 (1): 30–42. doi:10.1016/j.molcel.2008.11.023. PMC 2643372. PMID 19150425.

[pmid10882101-10] Takaesu, G; Kishida S; Hiyama A; Yamaguchi K; Shibuya H; Irie K; Ninomiya-Tsuji J; Matsumoto K (April 2000). "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". Mol. Cell (UNITED STATES) 5 (4): 649–58. doi:10.1016/S1097-2765(00)80244-0. ISSN 1097-2765. PMID 10882101.

[pmid9464265-11] Jang, I K; Lee Z H; Kim Y J; Kim S H; Kwon B S (January 1998). "Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B". Biochem. Biophys. Res. Commun. (UNITED STATES) 242 (3): 613–20. doi:10.1006/bbrc.1997.8016. ISSN 0006-291X. PMID 9464265.

[pmid9418902-12] Arch, R H; Thompson C B (January 1998). "4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB". Mol. Cell. Biol. (UNITED STATES) 18 (1): 558–65. ISSN 0270-7306. PMC 121523. PMID 9418902.

[pmid11112773-13] Feng, X; Gaeta M L; Madge L A; Yang J H; Bradley J R; Pober J S (March 2001). "Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors". J. Biol. Chem. (United States) 276 (11): 8341–9. doi:10.1074/jbc.M007116200. ISSN 0021-9258. PMID 11112773.

[pmid11805080-14] Cao, Haiming; Courchesne William E; Mastick Cynthia Corley (March 2002). "A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase". J. Biol. Chem. (United States) 277 (11): 8771–4. doi:10.1074/jbc.C100661200. ISSN 0021-9258. PMID 11805080.

[pmid9794406-15] Yamamoto, H; Kishimoto T; Minamoto S (November 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". J. Immunol. (UNITED STATES) 161 (9): 4753–9. ISSN 0022-1767. PMID 9794406.

[pmid9582383-16] Akiba, H; Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware C F, Malinin N L, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. ISSN 0021-9258. PMID 9582383. Cite uses deprecated parameters (help)

[pmid10880535-17] Xia, X Z; Treanor J, Senaldi G, Khare S D, Boone T, Kelley M, Theill L E, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng S Y, Boyle W J, Hsu H (July 2000). "Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation". J. Exp. Med. (UNITED STATES) 192 (1): 137–43. doi:10.1084/jem.192.1.137. ISSN 0022-1007. PMC 1887716. PMID 10880535. Cite uses deprecated parameters (help)

[pmid14743216-18] Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. Cite uses deprecated parameters (help)

[pmid10990461-19] Bonnard, M; Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itié A, Wakeham A, Shahinian A, Henzel W J, Elia A J, Shillinglaw W, Mak T W, Cao Z, Yeh W C (September 2000). "Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcription". EMBO J. (ENGLAND) 19 (18): 4976–85. doi:10.1093/emboj/19.18.4976. ISSN 0261-4189. PMC 314216. PMID 10990461. Cite uses deprecated parameters (help)

[pmid8702708-20] Takeuchi, M; Rothe M; Goeddel D V (August 1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. (UNITED STATES) 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. ISSN 0021-9258. PMID 8702708.

[pmid10411888-21] McWhirter, S M; Pullen S S; Holton J M; Crute J J; Kehry M R; Alber T (July 1999). "Crystallographic analysis of CD40 recognition and signaling by human TRAF2". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (15): 8408–13. doi:10.1073/pnas.96.15.8408. ISSN 0027-8424. PMC 17529. PMID 10411888.

[pmid9990007-22] Tsukamoto, N; Kobayashi N; Azuma S; Yamamoto T; Inoue J (February 1999). "Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. ISSN 0027-8424. PMC 15446. PMID 9990007.

[pmid9020361-23] Malinin, N L; Boldin M P; Kovalenko A V; Wallach D (February 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature (ENGLAND) 385 (6616): 540–4. doi:10.1038/385540a0. ISSN 0028-0836. PMID 9020361.

[pmid11057907-24] Deng, L; Wang C; Spencer E; Yang L; Braun A; You J; Slaughter C; Pickart C; Chen Z J (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain". Cell (UNITED STATES) 103 (2): 351–61. doi:10.1016/S0092-8674(00)00126-4. ISSN 0092-8674. PMID 11057907.

[pmid11278268-25] Luftig, M A; Cahir-McFarland E; Mosialos G; Kieff E (May 2001). "Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". J. Biol. Chem. (United States) 276 (18): 14602–6. doi:10.1074/jbc.C100103200. ISSN 0021-9258. PMID 11278268.

[pmid9712898-26] Yuasa, T; Ohno S; Kehrl J H; Kyriakis J M (August 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". J. Biol. Chem. (UNITED STATES) 273 (35): 22681–92. doi:10.1074/jbc.273.35.22681. ISSN 0021-9258. PMID 9712898.

[pmid11340079-27] Choi, Y H; Kim K B, Kim H H, Hong G S, Kwon Y K, Chung C W, Park Y M, Shen Z J, Kim B J, Lee S Y, Jung Y K (July 2001). "FLASH coordinates NF-kappa B activity via TRAF2". J. Biol. Chem. (United States) 276 (27): 25073–7. doi:10.1074/jbc.M102941200. ISSN 0021-9258. PMID 11340079. Cite uses deprecated parameters (help)

[pmid11804591-28] Oukka, Mohamed; Kim Sean T; Lugo Geancarlo; Sun Jenny; Wu Lai-Chu; Glimcher Laurie H (January 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Mol. Cell (United States) 9 (1): 121–31. doi:10.1016/S1097-2765(01)00434-8. ISSN 1097-2765. PMID 11804591.

[pmid8692885-29] Song, H Y; Rothe M; Goeddel D V (June 1996). "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6721–5. doi:10.1073/pnas.93.13.6721. ISSN 0027-8424. PMC 39093. PMID 8692885.

[pmid11907088-30] Hostager, Bruce S; Bishop Gail A (April 2002). "Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b". J. Immunol. (United States) 168 (7): 3318–22. doi:10.4049/jimmunol.168.7.3318. ISSN 0022-1767. PMID 11907088.

[pmid8710854-31] Rothe, M; Xiong J; Shu H B; Williamson K; Goddard A; Goeddel D V (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. ISSN 0027-8424. PMC 38654. PMID 8710854.

[pmid9162022-32] Marsters, S A; Ayres T M; Skubatch M; Gray C L; Rothe M; Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022.

[pmid18671942-33] Carpentier, Isabelle; Coornaert Beatrice; Beyaert Rudi (October 2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation". Biochem. Biophys. Res. Commun. (United States) 374 (4): 752–7. doi:10.1016/j.bbrc.2008.07.103. PMID 18671942.

[pmid8612133-34] Hsu, H; Huang J; Shu H B; Baichwal V; Goeddel D V (April 1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity (UNITED STATES) 4 (4): 387–96. doi:10.1016/S1074-7613(00)80252-6. ISSN 1074-7613. PMID 8612133.

[pmid8565075-35] Hsu, H; Shu H B; Pan M G; Goeddel D V (January 1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell (UNITED STATES) 84 (2): 299–308. doi:10.1016/S0092-8674(00)80984-8. ISSN 0092-8674. PMID 8565075.

[pmid8943045-36] Shu, H B; Takeuchi M; Goeddel D V (November 1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. ISSN 0027-8424. PMC 19479. PMID 8943045.

[pmid11777919-37] Xia, Pu; Wang Lijun, Moretti Paul A B, Albanese Nathaniel, Chai Fugui, Pitson Stuart M, D'Andrea Richard J, Gamble Jennifer R, Vadas Mathew A (March 2002). "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". J. Biol. Chem. (United States) 277 (10): 7996–8003. doi:10.1074/jbc.M111423200. ISSN 0021-9258. PMID 11777919. Cite uses deprecated parameters (help)

[pmid10514511-38] Ye, X; Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang J J, Leo E, Zapata J, Hauser C A, Reed J C, Bredesen D E (October 1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. (UNITED STATES) 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. ISSN 0021-9258. PMID 10514511. Cite uses deprecated parameters (help)

[pmid9153189-39] Hsu, H; Solovyev I; Colombero A; Elliott R; Kelley M; Boyle W J (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". J. Biol. Chem. (UNITED STATES) 272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. ISSN 0021-9258. PMID 9153189.

[pmid9244310-40] Régnier, C H; Song H Y; Gao X; Goeddel D V; Cao Z; Rothe M (July 1997). "Identification and characterization of an IkappaB kinase". Cell (UNITED STATES) 90 (2): 373–83. doi:10.1016/S0092-8674(00)80344-X. ISSN 0092-8674. PMID 9244310.

[pmid11882293-41] Yan, Minhong; Zhang Zemin; Brady John Ridgway; Schilbach Sarah; Fairbrother Wayne J; Dixit Vishva M (March 2002). "Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice". Curr. Biol. (England) 12 (5): 409–13. doi:10.1016/S0960-9822(02)00687-5. ISSN 0960-9822. PMID 11882293.

[pmid11479302-42] Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (September 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302. Cite uses deprecated parameters (help)

[pmid9685412-43] Darnay, B G; Haridas V; Ni J; Moore P A; Aggarwal B B (August 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". J. Biol. Chem. (UNITED STATES) 273 (32): 20551–5. doi:10.1074/jbc.273.32.20551. ISSN 0021-9258. PMID 9685412.

[pmid10075662-44] Darnay, B G; Ni J; Moore P A; Aggarwal B B (March 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". J. Biol. Chem. (UNITED STATES) 274 (12): 7724–31. doi:10.1074/jbc.274.12.7724. ISSN 0021-9258. PMID 10075662.

[pmid9852070-45] Galibert, L; Tometsko M E; Anderson D M; Cosman D; Dougall W C (Dec 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. (UNITED STATES) 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. ISSN 0021-9258. PMID 9852070.

[pmid10025951-46] Kim, H H; Lee D E; Shin J N; Lee Y S; Jeon Y M; Chung C H; Ni J; Kwon B S; Lee Z H (January 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Lett. (NETHERLANDS) 443 (3): 297–302. doi:10.1016/S0014-5793(98)01731-1. ISSN 0014-5793. PMID 10025951.

[pmid12571250-47] Kuai, Jun; Nickbarg Elliott; Wooters Joe; Qiu Yongchang; Wang Jack; Lin Lih-Ling (April 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. (United States) 278 (16): 14363–9. doi:10.1074/jbc.M208672200. ISSN 0021-9258. PMID 12571250.

[pmid10759890-48] Nomura, F; Kawai T; Nakanishi K; Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes Cells (ENGLAND) 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. ISSN 1356-9597. PMID 10759890.

[pmid10581243-49] Pomerantz, J L; Baltimore D (Dec 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". EMBO J. (ENGLAND) 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. ISSN 0261-4189. PMC 1171732. PMID 10581243.

[pmid8643514-50] Uren, A G; Pakusch M; Hawkins C J; Puls K L; Vaux D L (May 1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (10): 4974–8. doi:10.1073/pnas.93.10.4974. ISSN 0027-8424. PMC 39390. PMID 8643514.

[pmid9384571-51] Roy, N; Deveraux Q L; Takahashi R; Salvesen G S; Reed J C (Dec 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. (ENGLAND) 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. ISSN 0261-4189. PMC 1170295. PMID 9384571.

[pmid11907583-52] Li, Xiaoming; Yang Yili; Ashwell Jonathan D (March 2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature (England) 416 (6878): 345–7. doi:10.1038/416345a. ISSN 0028-0836. PMID 11907583.

[pmid16189514-53] Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Cite uses deprecated parameters (help)

[pmid10477597-54] Shi, C S; Leonardi A; Kyriakis J; Siebenlist U; Kehrl J H (September 1999). "TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related". J. Immunol. (UNITED STATES) 163 (6): 3279–85. ISSN 0022-1767. PMID 10477597.

[pmid9774977-55] Nishitoh, H; Saitoh M; Mochida Y; Takeda K; Nakano H; Rothe M; Miyazono K; Ichijo H (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell (UNITED STATES) 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. ISSN 1097-2765. PMID 9774977.

[pmid10523862-56] Hoeflich, K P; Yeh W C; Yao Z; Mak T W; Woodgett J R (October 1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)". Oncogene (ENGLAND) 18 (42): 5814–20. doi:10.1038/sj.onc.1202975. ISSN 0950-9232. PMID 10523862.

[pmid17015619-57] Gan, Boyi; Peng Xu; Nagy Tamas; Alcaraz Ana; Gu Hua; Guan Jun-Lin (October 2006). "Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways". J. Cell Biol. (United States) 175 (1): 121–33. doi:10.1083/jcb.200604129. ISSN 0021-9525. PMC 2064504. PMID 17015619.

[pmid10892748-58] Park, Y C; Ye H; Hsia C; Segal D; Rich R L; Liou H C; Myszka D G; Wu H (June 2000). "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction". Cell (UNITED STATES) 101 (7): 777–87. doi:10.1016/S0092-8674(00)80889-2. ISSN 0092-8674. PMID 10892748.

[pmid10911999-59] Tsao, D H; McDonagh T; Telliez J B; Hsu S; Malakian K; Xu G Y; Lin L L (June 2000). "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway". Mol. Cell (UNITED STATES) 5 (6): 1051–7. doi:10.1016/S1097-2765(00)80270-1. ISSN 1097-2765. PMID 10911999.

[pmid10346818-60] Baud, V; Liu Z G; Bennett B; Suzuki N; Xia Y; Karin M (May 1999). "Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain". Genes Dev. (UNITED STATES) 13 (10): 1297–308. doi:10.1101/gad.13.10.1297. ISSN 0890-9369. PMC 316725. PMID 10346818.

[pmid9104814-61] Lee, S Y; Lee S Y; Choi Y (April 1997). "TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation". J. Exp. Med. (UNITED STATES) 185 (7): 1275–85. doi:10.1084/jem.185.7.1275. ISSN 0022-1007. PMC 2196258. PMID 9104814.

匿名

検索

案内

案内

TRAF2