Control of Early Theiler's Murine Encephalomyelitis Virus Replication in Macrophages by Interleukin-6 Occurs in Conjunction with STAT1 Activation and Nitric Oxide Production.
Moore TC, Bush KL, Cody L, Brown DM, Petro TM.SourceSchool of Biological Sciences.
Journal of virology.J Virol.2012 Oct;86(19):10841-51. Epub 2012 Jul 25.
During Theiler's murine encephalomyelitis virus (TMEV) infection of macrophages, it is thought that high interleukin-6 (IL-6) levels contribute to the demyelinating disease found in chronically infected SJL/J mice but absent in B10.S mice capable of clearing the infection. Therefore, IL-6 expression
IL-1 signal affects both protection and pathogenesis of virus-induced chronic CNS demyelinating disease.
Kim BS, Jin YH, Meng L, Hou W, Kang HS, Park HS, Koh CS.AbstractABSTRACT:
Journal of neuroinflammation.J Neuroinflammation.2012 Sep 17;9(1):217. [Epub ahead of print]
ABSTRACT:BACKGROUND: Theiler's virus infection induces chronic demyelinating disease in mice and has been investigated as an infectious model for multiple sclerosis (MS). IL-1 plays an important role in the pathogenesis of both the autoimmune disease model (EAE) and this viral model for MS. However,
… Theiler's murine encephalomyelitis virus (TMEV) is divided into two subgroups on the basis of their different biological activities. … Therefore, L is thought to be a key protein for the subgroup-specific biological activities of TMEV. … Further analysis of L may help elucidate the pathomechanism (s) of TMEV-induced demyelinating disease. …
The Expression of L^* Protein during the Chronic Phase of Theiler's Murine Encephalomyelitis Virus (TMEV) Infection and the Role of Zinc-Binding Motif of L Protein in Virus Persistence and Demyelination
… Theiler's murine encephalomyelitis virus (TMEV) is divided into two subgroups on the basis of their different biological activities. … Two non-structural viral proteins, L and L, are reported to be critical in the biological activities of TMEV. …
MeV v4.8 includes new clValid module and new annotation. We are proud to announce the release of MeV v4.8. This release includes a new module for the statistical and biological validation of gene clusters, clValid, and updated annotation ...