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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/12 17:00:18」(JST)

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Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene.^[1] TLR8 has also been designated as CD288 (cluster of differentiation 288).

Function[edit]

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.^[2]

TLR8 recognizes G-rich oligonucleotides.^[3]

Clinical significance[edit]

Genetics variants in TLR8 has recently been linked to susceptibility to pulmonary tuberculosis.^[4]

References[edit]

^ Du X, Poltorak A, Wei Y, Beutler B (Dec 2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". Eur Cytokine Netw 11 (3): 362–71. PMID 11022119.
^ "Entrez Gene: TLR8 toll-like receptor 8".
^ Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T, Wang DY, Li Y, Wang HY, Wang RF (August 2005). "Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function". Science 309 (5739): 1380–4. doi:10.1126/science.1113401. PMID 16123302.
^ Davila S, Hibberd ML, Hari Dass R, Wong HEE, Sahiratmadja E, Bonnard C, Alisjahbana B, Szeszko JS, Balabanova Y, Drobniewski F, van Crevel R, van de Vosse E, Nejentsev S, Ottenhoff THM, Seielstad M (2008). "Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis". In Gojobori, Takashi. PLoS Genetics 4 (10): e1000218. doi:10.1371/journal.pgen.1000218. PMC 2568981. PMID 18927625.

External links[edit]

Toll-Like Receptor 8 at the US National Library of Medicine Medical Subject Headings (MeSH)

This biochemistry article is a stub. You can help Wikipedia by expanding it.

This article on a gene on the X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy
2. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
3. ヘルパーT細胞サブセット：疾患における分化および役割 t helper subsets differentiation and role in disease
4. 混合性結合組織病における抗U1-RNP抗体 anti u1 rnp antibodies in mixed connective tissue disease
5. ヒトヘルペスウイルス8感染のウイルス学、疫学、および伝播 virology epidemiology and transmission of human herpesvirus 8 infection

English Journal

Evaluation of Toll-like-receptor gene family variants as prognostic biomarkers in rheumatoid arthritis.

Torices S1, Alvarez-Rodríguez L2, Varela I3, Muñoz P4, Balsa A5, López-Hoyos M6, Martinez-Taboada V7, Fernández-Luna JL8.
Immunology letters.Immunol Lett.2017 Jul;187:35-40. doi: 10.1016/j.imlet.2017.04.011. Epub 2017 May 7.
PMID 28495399

Susceptibility and initial immune response of Tupaia belangeri cells to dengue virus infection.

Kayesh MEH1, Kitab B2, Sanada T3, Hayasaka D4, Morita K4, Kohara M3, Tsukiyama-Kohara K5.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.Infect Genet Evol.2017 Jul;51:203-210. doi: 10.1016/j.meegid.2017.04.003. Epub 2017 Apr 6.
PMID 28392469

Class II obese and healthy pregnant controls exhibit indistinguishable pro- and anti-inflammatory immune responses to Caesarian section.

Graham C1, Thorleifson M2, Stefura WP1, Funk DJ2, HayGlass KT1.
Immunity, inflammation and disease.Immun Inflamm Dis.2017 May 25. doi: 10.1002/iid3.174. [Epub ahead of print]
PMID 28544689

Japanese Journal

一本鎖核酸を認識するToll様受容体の構造解明及びその応用

YAKUGAKU ZASSHI 136(2), 173-178, 2016
NAID 130005121460

Toll様受容体8はRNAの分解物であるウリジンを認識する

臨床免疫・アレルギー科 = Clinical immunology & allergology 64(3), 294-298, 2015-09
NAID 40020592862

Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis

Scientific reports 4, 7290, 2014-12-03
NAID 120005539219

Related Pictures

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★リンクテーブル★

リンク元	「Toll様受容体8」「Toll-like receptor 8」
関連記事	「TL」

「Toll様受容体8」

Toll-like receptor 8
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	3W3G, 3W3J, 3W3K, 3W3L, 3W3M, 3W3N
Identifiers
Symbols	TLR8; CD288
External IDs	OMIM: 300366 MGI: 2176887 HomoloGene: 44054 ChEMBL: 5805 GeneCards: TLR8 Gene
Gene Ontology
Molecular function	• DNA binding; • RNA binding; • double-stranded RNA binding; • single-stranded RNA binding; • receptor activity;
Cellular component	• Golgi membrane; • endoplasmic reticulum membrane; • endosome membrane; • integral to membrane; • endolysosome membrane;
Biological process	• toll-like receptor signaling pathway; • MyD88-dependent toll-like receptor signaling pathway; • inflammatory response; • I-kappaB kinase/NF-kappaB cascade; • response to virus; • immunoglobulin mediated immune response; • toll-like receptor 8 signaling pathway; • toll-like receptor 9 signaling pathway; • positive regulation of interferon-gamma biosynthetic process; • innate immune response; • positive regulation of innate immune response; • positive regulation of interferon-alpha biosynthetic process; • positive regulation of interferon-beta biosynthetic process; • positive regulation of interleukin-8 biosynthetic process; • regulation of cytokine secretion; • defense response to virus; • cellular response to mechanical stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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