WordNet

being one more than nine (同)10, x
the cardinal number that is the sum of nine and one; the base of the decimal system (同)10, X, tenner, decade
the 20th letter of the Roman alphabet (同)t

PrepTutorEJDIC

〈C〉(数の)『10』,10の記号(10,Xなど) / 〈U〉10時,10分;10歳 / 〈U〉《複数扱い》10人,10個 / 〈C〉10(10人,10個)一組のもの / 〈C〉(カードケームの)10の札 / 『10の』,10人の,10個の / 《補語にのみ用いて》10歳の(で)
tritiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/02 23:28:40」(JST)

10 (ten ⁱ/ˈtɛn/) is an even natural number following 9 and preceding 11. Ten is the base of the decimal numeral system, by far the most common system of denoting numbers in both spoken and written language. The reason for the choice of ten is assumed to be that humans have ten fingers (digits).

1 Common usage and derived terms
2 In mathematics
- 2.1 In numeral systems
  - 2.1.1 Decimal system
  - 2.1.2 Roman numerals
  - 2.1.3 Positional numeral systems other than decimal
- 2.2 List of basic calculations
3 In science
- 3.1 Astronomy
4 In religion and philosophy
5 In money
6 In music
7 In sports and games
8 In technology
9 In other fields
10 See also
11 References

Common usage and derived terms

A collection of ten items (most often ten years) is called a decade.
The ordinal adjective is decimal; the distributive adjective is denary.
Increasing a quantity by one order of magnitude is most widely understood to mean multiplying the quantity by ten.
To reduce something by one tenth is to decimate. (In ancient Rome, the killing of one in ten soldiers in a cohort was the punishment for cowardice or mutiny; or, one-tenth of the able-bodied men in a village as a form of retribution, thus causing a labor shortage and threat of starvation in agrarian societies.)

In mathematics

Ten is a composite number, its proper divisors being 1, 2 and 5. Ten is the smallest noncototient, a number that cannot be expressed as the difference between any integer and the total number of coprimes below it.

Ten is the second discrete semiprime (2.5) and the second member of the (2.q) discrete semiprime family. Ten has an aliquot sum σ(n) of 8 and is accordingly the first discrete semiprime to be in deficit. All subsequent discrete semiprimes are in deficit. The aliquot sequence for 10 comprises five members (10,8,7,1,0) with this number being the second composite member of the 7-aliquot tree.

Ten is the smallest semiprime that is the sum of all the distinct prime numbers from its lower factor through its higher factor (10 = 2 + 3 + 5 = 2 . 5) Only three other small semiprimes (39, 155, and 371) share this attribute.

It is the aliquot sum of only one number the discrete semiprime 14.

Ten is a semi-meandric number.

Ten is the sum of the first three prime numbers, of the four first numbers (1 + 2 + 3 + 4), of the square of the two first odd numbers and also of the first four factorials (0! + 1! + 2! + 3!). Ten is the eighth Perrin number, preceded in the sequence by 5, 5, 7.

A polygon with ten sides is a decagon, and 10 is a decagonal number. Because 10 is the product of a power of 2 (namely 2¹) with nothing but distinct Fermat primes (specifically 5), a regular decagon is a constructible polygon.

Ten is also a triangular number, a centered triangular number, and a tetrahedral number.

Ten is the number of n-Queens Problem solutions for n = 5.

Ten is the smallest number whose status as a possible friendly number is unknown.

In numeral systems

Decimal system

As is the case for any base in its system, ten is the first two-digit number in decimal and thus the lowest number where the position of a numeral affects its value. Any integer written in the decimal system can be multiplied by ten by adding a zero to the end (e.g. 855 * 10 = 8550).

Roman numerals

The Roman numeral for ten is X (which looks like two V's [the Roman numeral for 5] put together); it is thought that the V for five is derived from an open hand (five digits displayed), and X for ten from both hands. Incidentally, the Chinese word numeral for ten, is also a cross: 十.

Positional numeral systems other than decimal

The digit '1' followed by '0' is how the value of p is written in base p. (E.g. 16 in hexadecimal is 10.)

Representation of 10 in other bases
Base	Numeral system	Number
1	unary	**********
2	binary	1010
3	ternary	101
4	quaternary	22
5	quinary	20
6	senary	14
7	septenary	13
8	octal	12
9	novenary	11
10	decimal	10
12	duodecimal	X
16	hexadecimal	A

Properties:

Ten is a Harshad number in bases 2, 3, 5, 6, 9 and all others above.
In bases 15, 18 and 30, ten is a 1-automorphic number (displayed as the numeral 'A')..

List of basic calculations

Multiplication	1	2	3	4	5	6	7	8	9	10		11	12	13	14	15	16	17	18	19	20		21	22	25		50	100	1000
	10	20	30	40	50	60	70	80	90	100		110	120	130	140	150	160	170	180	190	200		210	220	250		500	1000	10000

Division	1	2	3	4	5	6	7	8	9	10		11	12	13	14	15
	10	5		2.5	2			1.25		1
	0.1	0.2	0.3	0.4	0.5	0.6	0.7	0.8	0.9	1		1.1	1.2	1.3	1.4	1.5

Exponentiation	1	2	3	4	5	6	7	8	9	10
	10	100	1000	10000	100000	1000000	10000000	100000000	1000000000	10000000000
	1	1024	59049	1048576	9765625	60466176	282475249	1073741824	3486784401	10000000000

In science

The SI prefix for 10 is "deca-".

The meaning "10" is part of the following terms:

decapoda, an order of crustaceans with ten feet
decane, a hydrocarbon with 10 carbon atoms

Also, the number 10 plays a role in the following:

The atomic number of neon.
The number of hydrogen atoms in butane, a hydrocarbon.
The number of spacetime dimensions in some superstring theories.

Astronomy

The New General Catalogue object NGC 10, a magnitude 12.5 spiral galaxy in the constellation Sculptor.

The Saros number of the solar eclipse series which began on -2467 February 28 and ended on -1169 April 18. The duration of Saros series 10 was 1298.1 years, and it contained 73 solar eclipses.

The Saros number of the lunar eclipse series which began on -2454 June 17 and ended on -1138 August 15. The duration of Saros series 10 was 1316.2 years, and it contained 74 lunar eclipses.

Messier object M10, a magnitude 6.4 globular cluster in the constellation Ophiuchus.

In religion and philosophy

The tetractys

References in the Bible, Judaism and Christianity:
- The Ten Commandments of Exodus^[1] and Deuteronomy^[2] are considered a cornerstone of Judaism and Christianity.
- People traditionally tithed one-tenth of their produce. The practice of tithing is still common in Christian churches today, though it is disputed in some circles as to whether or not it is required of Christians.
- In Deuteronomy 26:12, the Torah commands Jews to give one-tenth of their produce to the poor (Maaser Ani). From this verse and from an earlier verse (Deut. 14:22) there derives a practice for Jews to give one-tenth of all earnings to the poor.^[3]
- Ten Plagues were inflicted on Egypt in Exodus 7-12
- Jews observe the annual Ten Days of Repentance beginning on Rosh Hashanah and ending on Yom Kippur.
- In Jewish liturgy, Ten Martyrs are singled out as a group.
- There are said to be Ten Lost Tribes of Israel (those other than Judah and Benjamin)
- There are Ten Sephirot in the Kabbalistic Tree of Life
- In Judaism, ten men are the required quorum, called a minyan, for prayer services.
- Interpretations of Genesis in Talmudic and Midrashic teachings suggest that on the first day, God drew forth ten primal elements from the abyss in order to construct all of Creation: Heaven (or Fire), Earth, Chaos, Void, Light, Darkness, Wind (or Spirit), Water, Day, and Night. See also Bereshit (parsha)
- Jesus tells the Parable of the Ten Virgins in Matthew 25:1-13.

In Pythagoreanism, the number 10 played an important role and was symbolized by the tetractys.
In Hinduism, Lord Maha Vishnu appeared on the earth in 10 incarnations.

In money

Most countries issue coins and bills with a denomination of 10 (See e.g. 10 dollar note). Of these, the dime, with the value of ten cents, or one tenth of a dollar, derives its name from the meaning "one-tenth" - see Dime (United States coin)#Denomination history and etymology.

In music

The interval of a major tenth is an octave plus a major third.
The interval of a minor tenth is an octave plus a minor third.
The title of quite a few albums. See Ten (album).
"Ten lords a-leaping" is the gift on the tenth day of Christmas in the carol "The Twelve Days of Christmas"

In sports and games

The meaning "10" is part of the following terms:

decathlon, a combined event in athletics consisting of ten track and field events.

Also, the number 10 plays a role in the following:

In American football, the end zones are 10 yards deep.
In association football, the number 10 is traditionally worn by the team's playmaker. This use has led to "Number 10" becoming a synonym for that particular player, even if he or she does not wear that number.
In Australian rules football, considered the break even amount of games won in a regular 22 game season.
In baseball, 10 is the minimum number of players on the field at any given time during play (including the batter).
In basketball:
- The top of the rim (goal) is 10 feet from the floor.
- In standard full-court basketball, there are 10 players on the court (5 on each team).
In blackjack, the Ten, Jack, Queen and King are all worth 10 points.
In boxing, if the referees counts to 10 whether the boxer is unconscious or not, it will declare a winner by knockout.
In cricket, 10 is the number of wickets required to be taken by the bowling side for the batting side to be bowled out.
In gridiron football, 10 is the number of yards the offense must advance to maintain possession in a single set of downs—four in American and three in Canadian.
In most rugby league competitions, the number 10 is worn by one of the two starting props. (One exception to this rule is the European Super League, which uses static squad numbering.)
In rugby union, the starting fly-half wears the 10 shirt.
In ten-pin bowling, 10 pins are arranged in a triangular pattern and there are 10 frames per game.
The highest score possible in Olympics gymnastics competitions.
Driving a racing car at ten-tenths is driving as fast as possible, on the limit.
Danica Patrick's car number in the NASCAR Sprint Cup Series.

The jersey number 10 has been retired by several North American sports teams in honor of past playing greats or other key figures, including Major League Baseball, the NBA, the NFL, and the NHL.

In technology

Ten-codes are commonly used on emergency service radio systems.
Ten refers to the "meter band" on the radio spectrum between 28 and 29.7 MHz, used by amateur radio.
ASCII and Unicode code point for line feed
In MIDI, Channel 10 is reserved for unpitched percussion instruments.
In the Rich Text Format specification, all language codes for regional variants of the Spanish language are congruent to 10 mod 256.
In OS X, the F10 function key tiles all the windows of the current application and grays the windows of other applications.
The IP addresses in the range 10.0.0.0/8 (meaning the interval between 10.0.0.0 and 10.255.255.255) is reserved for use by Private networks by RFC 1918.

In other fields

10 playing cards of all four suits

Blake Edwards' 1979 movie 10.
Series on HBO entitled 1st & Ten which aired between December 1984 and January 1991.
Series on ESPN and ESPN2 entitled 1st and 10 which launched on ESPN in October 2003 to 2008 and moved to ESPN2 from 2008 to present.
In astrology, Capricorn is the 10th astrological sign of the Zodiac.
In Chinese astrology, the 10 Heavenly Stems, refer to a cyclic number system that is used also for time reckoning.
An online show hosted by Microsoft.^[4]
A 1977 short documentary film Powers of Ten depicts the relative scale of the Universe in factors of ten (orders of magnitude).
CBS has a game show called Power of 10, where the player's prize goes up and down by either the previous or next power of ten.
"Ten Chances" is one the pricing games on The Price is Right.
There are ten official inkblots in the Rorschach inkblot test.
The traditional Snellen chart uses 10 different letters.
Ten is an Australian television network. The Sydney member of the network has the three-letter call-sign TEN and used to broadcast in analogue on VHF Channel 10.
Number Ten (also called Ella) is a character in the book series Lorien Legacies
The ten-code may be used in law-enforcement brevity communications.

Ten is:

Number of kingdoms in Five Dynasties and Ten Kingdoms period
House number of 10 Downing Street.
The number of Provinces in Canada.
The designation of United States Interstate 10, a freeway that runs from California to Florida.
Number of dots in a tetractys.
The number of the French department Aube.
The number of regions in Ghana.
The state number of Virginia.

References

^ Exodus 20:2-13
^ Deuteronomy 5:6-17
^ [1]
^ [2]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. スティーブンス・ジョンソン症候群および中毒性表皮壊死融解症：管理、予後、および長期の後遺症 stevens johnson syndrome and toxic epidermal necrolysis management prognosis and long term sequelae
2. スティーブンス・ジョンソン症候群および中毒性表皮壊死融解症：病因、臨床症状、および診断 stevens johnson syndrome and toxic epidermal necrolysis pathogenesis clinical manifestations and diagnosis
3. 薬疹 drug eruptions
4. 非選択性非ステロイド性抗炎症剤（NSAIDs）：副作用の概要 nonselective nsaids overview of adverse effects
5. 成人におけるてんかんの外科的治療 surgical treatment of epilepsy in adults

English Journal

Aroma enhancement in wines using co-immobilized Aspergillus niger glycosidases.

González-Pombo P, Fariña L, Carrau F, Batista-Viera F, Brena BM.SourceCátedra de Bioquímica, Departamento de Biociencias, Facultad de Química, Gral Flores 2124, CC1157 Montevideo, Uruguay.
Food chemistry.Food Chem.2014 Jan 15;143:185-91. doi: 10.1016/j.foodchem.2013.07.107. Epub 2013 Jul 29.
A major fraction of monoterpenes and norisoprenoids in young wines is conjugated to sugars representing a significant reservoir of aromatic precursors. To promote their release, β-glucosidase, α-arabinosidase, and α-rhamnosidase from a commercial Aspergillus niger preparation, were immobilized on
PMID 24054229

Cicer α-galactosidase immobilization onto functionalized graphene nanosheets using response surface method and its applications.

Singh N, Srivastava G, Talat M, Raghubanshi H, Srivastava ON, Kayastha AM.SourceSchool of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India.
Food chemistry.Food Chem.2014 Jan 1;142:430-8. doi: 10.1016/j.foodchem.2013.07.079. Epub 2013 Jul 26.
Cicer α-galactosidase was immobilized onto functionalized graphene with immobilization efficiency of 84% using response surface methodology (Box-Behnken design). The immobilized enzyme had higher thermal stability than the soluble one, attractive for industrial applications. Immobilization of the e
PMID 24001862

Simultaneous determination of ten steroid hormones in animal origin food by matrix solid-phase dispersion and liquid chromatography-electrospray tandem mass spectrometry.

Fan YB, Yin YM, Jiang WB, Chen YP, Yang JW, Wu J, Xie MX.SourceAnalytical & Testing Center of Beijing Normal University, Beijing 100875, China.
Food chemistry.Food Chem.2014 Jan 1;142:170-7. doi: 10.1016/j.foodchem.2013.06.104. Epub 2013 Jul 3.
An UPLC-MS/MS method for determination of ten steroid hormones in animal origin food has been developed with pretreatment of the samples by matrix solid-phase dispersion (MSPD). The MSPD conditions, including the dispersing sorbents, elution solvents, ratio of sorbent to sample and the volume of the
PMID 24001828

Japanese Journal

森の哲学--南方熊楠の環境保護活動

三村泰臣
広島工業大学研究紀要 33, 259-267, 36192-00-00
… devoting ten years to the protest. …
NAID 120005403193

Variations in the structure of airborne bacterial communities in a downwind area during an Asian dust (Kosa) event

Maki Teruya,Puspitasari Findya,Hara Kazutaka,Yamada Maromu,Kobayashi Fumihisa,Hasegawa Hiroshi,Iwasaka Yasunobu
Science of the Total Environment 488-489(1), 75-84, 2014-08-01
… The particle concentrations of bacterial cells and mineral particles were ten-fold higher during the Kosa event than on non-Kosa event days. …
NAID 120005440328

演劇教育における高校生の創造的対話空間の形成 -『Ｋ版星の王子さま』上演過程における教師の支援のアクションリサーチ-

加藤裕明
北海道大学大学院教育学研究院紀要 120, 231-253, 2014-06-30
… I analyzed an interaction among students by using ten kinds of text data. …
NAID 120005446652

Related Pictures

★リンクテーブル★

国試過去問	「106I040」「097A007」
リンク元	「スティーブンス・ジョンソン症候群」「インターフェロンα-2b」「パクリタキセル」「中毒性表皮壊死症」「薬疹」
拡張検索	「PTEN」「TENS」
関連記事	「T」「TE」

「106I040」

	← 10 11 12 13 14 15 16 17 18 19 → List of numbers — Integers ← 0 10 20 30 40 50 60 70 80 90 →
Cardinal	ten
Ordinal	10th; (tenth)
Numeral system	decimal
Factorization	2 × 5
Divisors	1, 2, 5, 10
Roman numeral	X
Roman numeral (unicode)	X, x
Greek prefix	deca-/deka-
Latin prefix	deci-
Binary	10102
Ternary	1013
Quaternary	224
Quinary	205
Senary	146
Octal	128
Duodecimal	A12
Hexadecimal	A16
Vigesimal	A20
Base 36	A36
Chinese numeral	十，拾
Hebrew	י (Yod)
Khmer	១០
Korean	십
Tamil	௰
Thai	๑๐
Devanāgarī	१०
Bangla	১০

　　[★]

68歳の女性。粘膜部のびらんと全身の発疹とを主訴に来院した。 5日前、風邪症状に対して市販の総合感冒薬を内服した。 2日間内服を続けたところ、 3日前から結膜充血と口腔内びらんとに加えて、顔面、体幹および四肢に紅斑とびらんとが出現した。初診時、全身の80%に紅斑が見られ、こすると容易にびらんを形成した。顔面の写真(別冊No. 6A)と、背部の紅斑をこすって生じたびらんの写真(別冊No. 6B)とを別に示す。
診断として考えられるのはどれか。

[正答]

※国試ナビ4※　［106I039］←［国試_106］→［106I041］

「097A007」

　　[★]

25歳の男性。皮疹を主訴に来院した。1週前から咽頭痛と37℃台の発熱とがあり、市販の感冒薬を内服していた。2日前から全身に灼熱感があり、皮膚をこするとズルリとむける。血液所見：赤沈40mm/1時間、赤血球410万、Hb13.5g/dl、白血球9,500。皮膚病変の写真を以下に示す。

考えられるのはどれか。

[正答]

※国試ナビ4※　［097A006］←［国試_097］→［097A008］

「スティーブンス・ジョンソン症候群」

　　[★]

英: Stevens-Johnson syndrome, SJS
同: スティーヴンス-ジョンソン症候群 Stevens-Johnson症候群スティーヴンス・ジョンソン症候群スチーブンス・ジョンソン症候群、皮膚粘膜眼症候群、粘膜・皮膚・眼症候群
関: 多形滲出性紅斑(多形紅斑)、中毒性表皮壊死症(TEN)

概念

多形紅斑　＋　粘膜(口腔粘膜、外陰部、鼻粘膜、肛門周囲)・眼(眼球、眼瞼結膜)の病変(びらん、水疱、出血性水疱)　＋　全身症状(発熱、全身倦怠、関節痛、筋痛、胸痛、胃腸障害)
中毒性表皮壊死症(TEN)に進展しうる。

スティーブンス・ジョンソン症候群と中毒性表皮壊死症

スティーブンス・ジョンソン症候群と中毒性表皮壊死症は独立した概念か、あるいは重症度の違いによる区分かについては統一見解がない、と思う。(文献ではぼかして書いてあるためにいまいちわかりにくい)

資料1では重症度の違いによるという立場に基づき以下のように定義している。

スティーブンス・ジョンソン症候群：体表面積の10%以下の表皮が剥脱する。90%以上の患者で2箇所以上の粘膜(眼、口腔、会陰)に病変を有する。

中毒性表皮壊死症：体表面積の30%以上の表皮が剥脱する。粘膜は全例で冒される。

SJS/TEN overlap syndrome：体表面積の10～30%の表皮が剥脱する。

症状

[show details]

皮疹：四肢伸側～顔面～体幹。浮腫が強い多形紅斑。水疱や出血を伴う。
粘膜症状：(口腔粘膜、外陰部、鼻粘膜、肛門周囲)：びらん、水疱、出血性水疱
眼症状：(眼球、眼瞼結膜)：びらん、水疱、出血性水疱
全身症状：発熱、全身倦怠、関節痛、筋痛、胸痛、胃腸障害
重症：上気道粘膜・消化管粘膜

検査

参考2(中毒性表皮壊死症の場合)

貧血所見(赤血球・Hb減少?)
リンパ球：減少
好酸球：正常。増多はまれ
好中球：減少(1/3の患者で見られ、予後不良と関連がある)
血清アミノトランスフェラーぜ：(値は2-3倍を示す。1/2の患者で見られる。肝炎は10%の患者で見られる)

原因

薬剤性

感染症：ウイルス、マイコプラズマ、溶血性レンサ球菌などの細菌、真菌などの感染

参考

1. [charged] スティーブンス・ジョンソン症候群および中毒性表皮壊死融解症：管理、予後、および長期の後遺症 - uptodate [1]
2. [charged] スティーブンス・ジョンソン症候群および中毒性表皮壊死融解症：臨床症状、病因;および診断 - uptodate [2]

国試

103C028、103C029、102A033

「インターフェロンα-2b」

　　[★]

英: interferon-α-2b IFN-α-2b
同: インターフェロンアルファ-2b
商: イントロンA、ペグイントロン

効能又は効果

イントロンA

次のいずれかのC型慢性肝炎におけるウイルス血症の改善

(1) 本剤単独の場合

1) 血中HCV RNA量が高値ではない患者

(2) リバビリンとの併用の場合

1) 血中HCV RNA量が高値の患者

2) インターフェロン製剤単独療法で無効の患者又はインターフェロン製剤単独療法後再燃した患者

HBe抗原陽性でかつDNAポリメラーゼ陽性のB型慢性活動性肝炎のウイルス血症の改善
腎癌(腎細胞癌？)、慢性骨髄性白血病、多発性骨髄腫

禁忌

イントロンA

1. 本剤又は他のインターフェロン製剤に対し過敏症の既往歴のある患者
2. ワクチン等生物学的製剤に対して過敏症の既往歴のある患者
3. 小柴胡湯を投与中の患者（「相互作用」の項参照）
4. 自己免疫性肝炎の患者［自己免疫性肝炎が悪化することがある。］

重大な副作用

イントロンA

本剤単独

(1)間質性肺炎(0.1～5%未満)、肺線維症(0.1%未満)、肺水腫(頻度不明)　→　副腎皮質ステロイド投与など
(2)抑うつ・うつ病(0.1～5%未満)、自殺企図、躁状態(0.1%未満)、攻撃的行動(頻度不明)　→　不眠、不安、焦燥、興奮、攻撃性、易刺激性等があらわれた場合には投与を中止
(3)意識障害、興奮(頻度不明)、痙攣、見当識障害、せん妄、幻覚、妄想、統合失調症様症状、失神、認知症様症状(特に高齢者)、難聴(0.1%未満)、錯乱(0.1～5%未満)　→　中止
(4)自己免疫現象(0.1%未満)　→　甲状腺機能異常、肝炎、溶血性貧血、特発性血小板減少性紫斑病(ITP)、潰瘍性大腸炎、関節リウマチ、乾癬、全身性エリテマトーデス、血管炎、フォークト・小柳・原田病、インスリン依存型糖尿病(IDDM)の増悪又は発症
(5)溶血性尿毒症症候群(HUS)、血栓性血小板減少性紫斑病(TTP)(頻度不明)
(6)糖尿病(0.1～5%未満)　→　糖尿病［インスリン依存型(IDDM)及びインスリン非依存型(NIDDM)］の増悪・発症　→　糖尿病性ケトアシドーシス、昏睡
(7)重篤な肝障害(頻度不明)　→　中止
(8)急性腎不全等の重篤な腎障害(頻度不明)
(9)再生不良性貧血(頻度不明)、汎血球減少(0.1～5%未満)、無顆粒球症、白血球減少(2,000/mm3未満)、血小板減少(50,000/mm3未満)(頻度不明)
(10)ショック(0.1%未満)
(11)心筋症(頻度不明)、心不全(0.1%未満)、心筋梗塞(頻度不明)、狭心症(0.1%未満)
(12)不整脈(0.1～5%未満)
(13)消化管出血(下血、血便等)、消化性潰瘍(0.1%未満)、虚血性大腸炎(頻度不明)
(14)脳出血(0.1%未満)
(15)脳梗塞(頻度不明)
(16)敗血症(0.1%未満)　→　易感染性
(17)網膜症(0.1～5%未満)　→網膜出血や糖尿病網膜症の増悪に注意
(18)中毒性表皮壊死融解症(Toxic Epidermal Necrolysis TEN)(頻度不明)、皮膚粘膜眼症候群(Stevens-Johnson症候群)(0.1%未満)
(19)横紋筋融解症(頻度不明)

国試

104G064

「パクリタキセル」

　　[★]

英: paclitaxel
商: タキソール taxol TXL、(アルブミン添加)アブラキサン
関: 抗悪性腫瘍薬

分類

抗悪性腫瘍薬

タキサン系

適応

パクリタキセル注

卵巣癌、非小細胞肺癌、乳癌、胃癌、子宮体癌、再発又は遠隔転移を有する頭頸部癌、再発又は遠隔転移を有する食道癌、血管肉腫、進行又は再発の子宮頸癌

作用機序

チューブリンの脱重合を抑制して、中間径フィラメントを安定化させることで有糸分裂期(M期)を停止させ、これにより細胞分裂を阻害　(⇔ ビンクリスチン)

重要な基本的注意

骨髄抑制。過敏反応。低血圧、高血圧、徐脈。関節痛(高頻度)、筋肉痛(高頻度)。発熱(高頻度)。末梢神経障害(高頻度)。感染症、出血傾向。

重大な副作用

ショック、アナフィラキシー様症状。白血球減少等の骨髄抑制。末梢神経障害、麻痺。間質性肺炎、肺線維症。急性呼吸窮迫症候群。心筋梗塞、うっ血性心不全、心伝導障害、肺塞栓、血栓性静脈炎、脳卒中、肺水腫。難聴、耳鳴。消化管壊死、消化管穿孔、消化管出血、消化管潰瘍。重篤な腸炎。腸管閉塞、腸管麻痺。肝機能障害、黄疸。膵炎。急性腎不全。中毒性表皮壊死融解症(Toxic Epidermal Necrolysis, TEN)、皮膚粘膜眼症候群(Stevens-Johnson症候群)。播種性血管内凝固症候群(DIC)

「中毒性表皮壊死症」

　　[★]

英: toxic epidermal necrolysis, TEN
関: ライエル症候群、Lyell型薬疹
関: 薬疹、術後薬物アレルギー、難病(重症多形滲出性紅斑として)

[show details]

中毒性表皮壊死症 : 約 132,000 件
中毒性表皮融解壊死症 : 45 件
中毒性表皮壊死剥離症 : 約 79,000 件
中毒性表皮壊死融解症 : 約 192,000 件

治療

原因薬物の中止
支持療法：創傷管理、済み・電解質管理、栄養補給、眼の管理、体温管理、疼痛管理、感染予防
補助療法：支持療法を超える有効で確立された治療はない。

糖質コルチコイド
γグロブリン製剤
併用療法：糖質コルチコイド+IVIG
血漿交換(plasmapheresis)
免疫抑制薬(シクロスポリン)
サリドマイド：禁忌。TNF-α阻害作用があるが、TENに対しては死亡率を高めたという結果が出ている。

参考

1. 重篤副作用疾患別対応マニュアル中毒性表皮壊死症（中毒性表皮壊死融解症）（ライエル症候群、ライエル症候群型薬疹）

http://www.mhlw.go.jp/topics/2006/11/dl/tp1122-1a05.pdf

2. [charged] Stevens-Johnson syndrome and toxic epidermal necrolysis: Management, prognosis, and long-term sequelae - uptodate [3]

「薬疹」

　　[★]

英: drug eruption, drug rash
関: 薬疹検査法、薬疹の診方と対応

薬疹

アレルギー機序による薬疹
非アレルギー機序による薬疹

特殊な薬疹

固定薬疹 fixed drug eruption
中毒性表皮壊死症 toxic epidermal necrolysys TEN = Lyell型薬疹

中毒性表皮壊死症～Stevens-Johnson症候群～多形紅斑

薬剤性過敏症症候群 drug-induced hypersensitivity syndrome DIHS

手掌、足底には出ない

「PTEN」

　　[★]

英: phosphatase and tensin homolog
日: ホスファターゼ・テンシン・ホモログ

癌抑制遺伝子
http://ja.wikipedia.org/wiki/PTEN
http://en.wikipedia.org/wiki/PTEN_(gene)

「TENS」

　　[★] 経皮的神経電気刺激法 transcutaneous electric nerve stimulation、transcutaneous electrical nerve stimulation

「T」

　　[★]

「TE」

　　[★] エコー時間 echo time

[1] Exodus 20:2-13

[2] Deuteronomy 5:6-17

[3] [1]

[4] [2]

匿名

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案内

TEN

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Contents

Common usage and derived terms

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★リンクテーブル★

「106I040」

「097A007」

「スティーブンス・ジョンソン症候群」

概念

スティーブンス・ジョンソン症候群と中毒性表皮壊死症

症状

検査

原因

参考

国試

「インターフェロンα-2b」

効能又は効果

禁忌

重大な副作用

国試

「パクリタキセル」

分類

適応

作用機序

重要な基本的注意

重大な副作用

「中毒性表皮壊死症」

治療

参考

「薬疹」

「PTEN」

「TENS」

「T」

「TE」