WordNet

a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
Scottish philosopher and follower of Thomas Reid (1753-1828) (同)Dugald Stewart
United States film actor who portrayed incorruptible but modest heros (1908-1997) (同)Jimmy Stewart, James Maitland Stewart

PrepTutorEJDIC

(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
=Stuart

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/28 00:35:36」(JST)

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Stewart–Treves syndrome, also known as cutaneous angiosarcoma, refers to a lymphangiosarcoma, a rare complication that forms as a result of chronic, long-standing lymphedema. Although it most commonly refers to malignancies associated with chronic lymphedema resulting from mastectomy and/or radiotherapy for breast cancer,^[1] it may also describe lymphangiosarcomas that result from congenital and other causes of chronic secondary lymphedema.^[2] Lymphangiosarcoma arising from cancer-related lymphedema has become much less common with better surgical techniques, radiation therapy, and conservative treatment.^[3] The prognosis, even with wide surgical excision and subsequent radiotherapy, is poor.^[4]

History

It was discovered by Fred W. Stewart and Norman Treves in 1948.

Incidence

In the 1960s, the incidence 5 years after a radical mastectomy varied from 0.07% to 0.45%.^[5] Today, it occurs in 0.03% of patients surviving 10 or more years after radical mastectomy.^[6]

Treatment

The treatment of choice is a large resection or amputation of the affected limb. Radiation therapy can precede or follow surgical treatment. Tumors that have advanced locally or have metastasized can be treated with mono or polychemotherapy, systemically or locally.^[6] However, chemotherapy and radiation therapy have not been shown to improve survivorship significantly.^[2]

Prognosis

Early detection is key. Untreated patients usually live 5 to 8 months after diagnosis.^[2]

References

^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ ^a ^b ^c Sharma, A; Schwartz, RA (June 2012). "Stewart-Treves syndrome: Pathogenesis and management.". J Am Acad Dermatol 67 (6): 1342–8. doi:10.1016/j.jaad.2012.04.028. PMID 22682884.
^ Kumar MBBS MD FRCPath, Vinay (2010). Robins and Cotran: Pathologic Basis of Disease 8th Edition. Philadelphia, PA: Saunders Elsevier. p. 1093. ISBN 978-1-4160-3121-5.
^ Pincus LB, Fox LP (August 2008). "Images in clinical medicine. The Stewart-Treves syndrome". N. Engl. J. Med. 359 (9): 950. doi:10.1056/NEJMicm071344. PMID 18753651.
^ Heitmann, C; Ingianni, G (January 2000). "Stewart-Treves syndrome: lymphangiosarcoma following mastectomy.". Ann Plast Surg. 44 (1): 72–5. doi:10.1097/00000637-200044010-00012. PMID 10651369.
^ ^a ^b Wierzbicka-Hainaut, E; Guillet, G (December 2010). "[Stewart-Treves syndrome (angiosarcoma on lyphoedema): A rare complication of lymphoedema]". Presse Med. 39 (12): 1305–8. doi:10.1016/j.lpm.2010.06.017. PMID 20970956.

UpToDate Contents

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1. Clinical features and diagnosis of peripheral lymphedema
2. 放射線関連肉腫 radiation associated sarcomas
3. 乳房肉腫：疫学、危険因子、臨床症状、診断、およびステージング breast sarcoma epidemiology risk factors clinical presentation diagnosis and staging
4. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
5. Clinical staging and conservative management of peripheral lymphedema

English Journal

Lymphangiosarcoma: Is Stewart-Treves Syndrome a Preventable Condition?

Felmerer G1, Dowlatshahi AS2,3, Stark GB3, Földi E4, Földi M4, Ahls MG5, Ströbel P5, Aung T1.
Lymphatic research and biology.Lymphat Res Biol.2015 Nov 19. [Epub ahead of print]
BACKGROUND: Stewart-Treves syndrome is a rare complication of breast cancer treatment, representing a lymphangiosarcoma commonly associated with lymphedema and severely impacting patient's outcome. The tumor typically develops in the atrophic, pachydermatous, hyperkeratotic skin of limbs affected by
PMID 26584023

[An arm lesion].

Lebarbier-Dumesnil A1, Cailleux-Talbot N2, Armengol G2, Lévesque H2, Benhamou Y2.
La Revue de medecine interne / fondee ... par la Societe nationale francaise de medecine interne.Rev Med Interne.2015 Oct 9. pii: S0248-8663(15)00638-4. doi: 10.1016/j.revmed.2015.09.002. [Epub ahead of print]
PMID 26460195

Stewart-Treves Syndrome of the Breast after Quadrantectomy for Breast Carcinoma.

Miglino B1, Maldi E2, Tiberio R1, Boggio P1, Astolfi S1, Franchini R3, Zavattaro E1, Boldorini R2, Colombo E1.
The breast journal.Breast J.2015 Sep-Oct;21(5):552-4. doi: 10.1111/tbj.12457. Epub 2015 Jul 23.
PMID 26205517