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1. アレルギー性鼻炎および結膜炎に対する補完代替療法 complementary and alternative therapies for allergic rhinitis and conjunctivitis

Senegenin Inhibits Hypoxia/Reoxygenation-Induced Neuronal Apoptosis by Upregulating RhoGDIα.

Li X1,2, Zhao Y1, Liu P1, Zhu X1,3, Chen M4, Wang H1, Lu D1, Qi R5.
Molecular neurobiology.Mol Neurobiol.2015 Dec;52(3):1561-71. doi: 10.1007/s12035-014-8948-6. Epub 2014 Nov 4.
Neuronal apoptosis is an important event in hypoxia/reoxygenation (H/R)-induced neuronal injury. Senegenin (Sen), the predominant and most active component in Radix Polygalae root extracts, displays anti-apoptotic and anti-oxidative properties. Sen protects against H/R-induced neuronal apoptosis of
PMID 25367882

Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins.

Wu AG1, Kam-Wai Wong V1, Zeng W1, Liu L1,1, Yuen-Kwan Law B1.
Scientific reports.Sci Rep.2015 Nov 24;5:17199. doi: 10.1038/srep17199.
With its traditional use in relieving insomnia and anxiety, our previous study has identified onjisaponin B from Radix Polygalae (RP), as a novel autophagic enhancer with potential neuroprotective effects. In current study, we have further identified a novel active fraction from RP, contains 17 majo
PMID 26598009

Indirect identification of antioxidants in Polygalae Radix through their reaction with 2,2-diphenyl-1-picrylhydrazyl and subsequent HPLC-ESI-Q-TOF-MS/MS.

Shi Q1, Chen J2, Zhou Q2, Lei H2, Luan L2, Liu X2, Wu Y3.
Talanta.Talanta.2015 Nov 1;144:830-5. doi: 10.1016/j.talanta.2015.07.032. Epub 2015 Jul 11.
A rapid and efficient method for the identification of antioxidants in the traditional Chinese medicine Polygalae Radix (PR) by HPLC-ESI-Q-TOF-MS/MS is described. The method is based on the hypothesis that upon reaction of antioxidants with 1,1-diphenyl-2-picrylhydrazyl (DPPH), the peak areas of com
PMID 26452897

Potential Antiarrhythmic Effect of Methyl 3,4,5-Trimethoxycinnamate, a Bioactive Substance from Roots of Polygalae Radix : Suppression of Triggered Activities in Rabbit Myocytes

Potential Antiarrhythmic Effect of Methyl 3,4,5-Trimethoxycinnamate, a Bioactive Substance from Roots of Polygalae Radix: Suppression of Triggered Activities in Rabbit Myocytes

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Biological and Pharmaceutical Bulletin 36(2), 238-244, 2013
… 3,4,5-Trimethoxycinnamic acid (TMCA), methyl 3,4,5-trimethoxycinnamate (M-TMCA) and p-methoxycinnamic acid (PMCA) have been identified as the major bioactive components in the serum collected from rats treated with oral administration of Polygalae Radix ("YuanZhi," the roots of Polygala tenuifolia WILLD.), a traditional Chinese medicine used to relieve insomnia, anxiety and heart palpitation. …
NAID 130002480757

Cerebral Protective and Cognition-Improving Effects of Sinapic Acid in Rodents(Pharmacology)

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Biological & pharmaceutical bulletin 30(3), 514-519, 2007-03-01
… We previously demonstrated that tenuifoliside B and 3,6'-disinapoylsucrose in Polygalae Radix, the root of Polygala tenmfolia WILLDENOW, inhibited potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice. …
NAID 110006239195