Plasmodium yoelii

プラスモディウム・ヨエリ、ネズミマラリア原虫

関

Plasmodium berghei、Plasmodium chabaudi

WordNet

1. parasitic protozoan of the genus Plasmodium that causes malaria in humans (同)Plasmodium_vivax, malaria parasite
2. multinucleate sheet of cytoplasm characteristic of some stages of such organisms as slime molds

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/19 19:10:40」(JST)

wiki en

[Wiki en表示]

Plasmodium yoelii
Scientific classification
Kingdom:	Protista
Phylum:	Apicomplexa
Class:	Aconoidasida
Order:	Haemosporida
Family:	Plasmodiidae
Genus:	Plasmodium
Species:	P. yoelii
Binomial name
Plasmodium yoelii

Plasmodium yoelii is a parasite of the genus Plasmodium subgenus Vinckeia.

Like all Plasmodium species P. yoelii has both vertebrate and insect hosts. The vertebrate hosts for this parasite are mammals.

Description

This species was described in 1968 by Landau, Michel and Adam.

Geographical occurrence

This species occurs in Africa.

Vectors

The natural vectors of this species are not currently known.

Clinical features and host pathology

This species infects Thamnonys rutilans

Notes

Three subspecies are recognised: P. yoelii killicki, P. yoelii nigeriensis and P. yoelii yoelli.

Its most notable feature is that it is used in the laboratory to infect mice, as a model of human malaria, particularly with respect to the immune response.

It is advantageous to have a whole-animal model of malaria because often it is difficult to know which factors to study in vitro, particularly in a complex system like the immune system. Moreover, for many experiments it is not ethical or practical to use humans.

One of the special things about this particular model is that it has two strains with vastly different pathogenicity. These are generally referred to as the "lethal" and "non-lethal" strains of the species. Comparison of these two strains can be used to deduce which factors may contribute to more serious malaria infections in humans.

References

Further reading

• Charoenvit, Yupin; Leef, Mary; Yuan, Leo; Sedegah, Martha; Beaudoin, Richard (March 1987). "Characterization of Plasmodium yoelii Monoclonal Antibodies Directed Against Stage-specific Sporozoite Antigens". Infection and Immunity 55 (1987): 5. PMID 2434426. 
• Keitany, Gladys J.; Sack, Brandon; Smithers, Hannah; Chen, Lin; Jang, Ihn K.; Sebastian, Leslie (December 2012). "Immunization of Mice with Live-Attenuated Late Liver Stage-Arresting Plasmodium yoelii Parasites Generates Protective Antibody Responses to Preerythrocytic Stages of Malaria". Infection and Immunity 82 (12): 5143–5153. doi:10.1128/IAI.02320-14. 
• White, Chelsi E.; Villarino, Nicolas F.; Sloan, Sarah S.; Ganusov, Vitaly V.; Schmidt, Nathan W. (10 December 2014). "Plasmodium Suppresses Expansion of T Cell Responses to Heterologous Infections". The Journal of Immunology 194 (2): 697–708. doi:10.4049/jimmunol.1401745. 
• Valeelat O., Okeola; Oluwatosin A., Adaramoye; Chiaka M., Nneji (January 2011). "Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis". PARASITOLOGY RESEARCH 108 (6): 1507–1512. doi:10.1007/s00436-010-2204-4. PMID 21153838. 
• Harupa, Anke; Sack, Brandon; Lashmanan, Viswanathan. "SSP3 Is a Novel Plasmodium yoelii Sporozoite Surface Protein with a Role in Gliding Motility". Infection and Immunity 82 (11): 4643–4653. doi:10.1128/IAI.01800-14. 
• Kaushansky, Alexis; Austin, Laura S.; Mikolajczak, Sebastian A.; Fang, Y. Lo; Miller, Jessica A.; Douglass, Alyse N.; Arang, Nadia; Vaughan, Ashley M.; Gardner, Malcom J.; Kappe, Stefan H. I. (January 2015). "Susceptibility to Plasmodium yoelii Preerythrocytic Infection in BALB/c Substrains Is Determined at the Point of Hepatocyte Invasion". Infection and Immunity 83 (1): 39-47. doi:10.1128/IAI.02230-14. 

External links

Information about the genome and genes of P. yoelii

• www.genedb.org/Homepage/PyoeliiYM

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. Overview of non-falciparum malaria in nonpregnant adults and children
• 2. 旅行者におけるマラリア感染の予防 prevention of malaria infection in travelers
• 3. 異常ヘモグロビン症におけるマラリアに対する防御 protection against malaria in the hemoglobinopathies
• 4. Clinical manifestations of malaria in nonpregnant adults and children
• 5. マラリアの診断 diagnosis of malaria

English Journal

• Repetitive live sporozoites inoculation under arteether chemoprophylaxis confers protection against subsequent sporozoite challenge in rodent malaria model.

• Bhardwaj J1, Siddiqui AJ1, Goyal M2, Prakash K2, Soni A1, Puri SK3.
• Acta tropica.Acta Trop.2016 Jun;158:130-8. doi: 10.1016/j.actatropica.2016.02.016. Epub 2016 Feb 27.
• Inoculation with live sporozoites under prophylactic antimalarial cover (CPS-immunization) represents an alternate approach to develop sterile, reproducible, and long-term protection against malaria. Here, we have employed arteether (ART), a semi synthetic derivative of artemisinin to explore its po
• PMID 26925772

• Plasmodium yoelii infection of BALB/c mice results in expansion rather than induction of CD4(+) Foxp3(+) regulatory T cells.

• Abel S1, Ueffing K1, Tatura R1, Hutzler M1, Hose M1, Matuschewski K2, Kehrmann J1, Westendorf AM1, Buer J1, Hansen W1.
• Immunology.Immunology.2016 Jun;148(2):197-205. doi: 10.1111/imm.12602. Epub 2016 Mar 23.
• Recently, we demonstrated elevated numbers of CD4(+) Foxp3(+) regulatory T (Treg) cells in Plasmodium yoelii-infected mice contributing to the regulation of anti-malarial immune response. However, it remains unclear whether this increase in Treg cells is due to thymus-derived Treg cell expansion or
• PMID 26932746

• Antimalarial activity of small molecule benzothiazole hydrazones.

• Sarkar S1, Siddiqui AA1, Saha SJ1, De R1, Mazumder S1, Banerjee C1, Iqbal MS1, Nag S1, Adhikari S2, Bandyopadhyay U3.
• Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2016 May 2. pii: AAC.01575-15. [Epub ahead of print]
• We synthesized a new series of conjugated hydrazones that were found to be active against malaria parasite in vitro as well as in vivo in murine model. These hydrazones concentration-dependently chelated free iron and offered antimalarial activity. Upon screening of the synthesized hydrazones, compo
• PMID 27139466

Japanese Journal

• Early Treatment with Chloroquine Inhibits the Immune Response against Plasmodium yoelii Infection in Mice

• Qin Xiaosong,Chen Guang,Feng Yonghui,Zhu Xiaotong,Du Yunting,Pang Wei,Qi Zanmei,Cao Yaming
• The Tohoku Journal of Experimental Medicine 234(4), 271-280, 2014
• … DBA/2 mice were infected with Plasmodium yoelii (Py) parasite (intraperitoneal injection of parasitized erythrocytes) and divided into three groups. …
• NAID 130004704764

• CD8+ T cell activation by murine erythroblasts infected with malaria parasites

• Imai Takashi,Ishida Hidekazu,Suzue Kazutomo,Hirai Makoto,Taniguchi Tomoyo,Okada Hiroko,Suzuki Tomohisa,Shimokawa Chikako,Hisaeda Hajime
• Scientific Reports 3, 1572, 2013-03-28
• … Recent studies show that some human malaria parasite species Plasmodium falciparum and P. … yoelii 17XNL) expressing GFP-ovalbumin (OVA). …
• NAID 120005231349

• Accumulation of major histocompatibility complex class Ⅱ⁺CD11c⁻ non-lymphoid cells in the spleen during infection with Plasmodium yoelii is lymphocyte-dependent

• Kamei Rika,Miyakoda Mana,Tamura Takahiko [他]
• Microbiology and immunology 57(3), 213-223, 2013-03
• NAID 40019615155

Related Links

• Plasmodium yoelii - Wikipedia, the free encyclopedia

Plasmodium yoelii is a parasite of the genus Plasmodium subgenus Vinckeia. Like all Plasmodium species P. yoelii has both vertebrate and insect hosts. The vertebrate hosts for this parasite are mammals.

• Plasmodium yoelii - Wellcome Trust Sanger Institute

29 Nov 2012 ... Plasmodium yoelii yoelii has been isolated from the blood of shiny thicket rats from the Central African Republic, from Brazzaville and from Western Nigeria. Three subspecies are recognized, P. yoelii yoelii, P. yoelii killicki and ...

Related Pictures

---

★リンクテーブル★

リンク元	「ネズミマラリア原虫」「Plasmodium chabaudi」「Plasmodium berghei」「プラスモディウム・ヨエリ」
関連記事	「Plasmodium」

「ネズミマラリア原虫」

　　[★]

ラ

Plasmodium yoelii、Plasmodium berghei、Plasmodium chabaudi

関

プラスモディウム・ベルゲイ、プラスモディウム・シャバウディ、プラスモディウム・ヨエリ

「Plasmodium chabaudi」

　　[★]

プラスモディウム・シャバウディ、ネズミマラリア原虫

関

Plasmodium berghei、Plasmodium yoelii

「Plasmodium berghei」

　　[★]

プラスモディウム・ベルゲイ、ネズミマラリア原虫

関

Plasmodium chabaudi、Plasmodium yoelii

「プラスモディウム・ヨエリ」

　　[★]

ラ

Plasmodium yoelii

関

ネズミマラリア原虫

「Plasmodium」

　　[★] プラスモディウム属