プラスモディウム・シャバウディ、ネズミマラリア原虫
- 関
- Plasmodium berghei、Plasmodium yoelii
WordNet
- parasitic protozoan of the genus Plasmodium that causes malaria in humans (同)Plasmodium_vivax, malaria parasite
- multinucleate sheet of cytoplasm characteristic of some stages of such organisms as slime molds
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/29 11:17:28」(JST)
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| Plasmodium chabaudi |
| Scientific classification |
| Kingdom: |
Protista |
| Phylum: |
Apicomplexa |
| Class: |
Aconoidasida |
| Order: |
Haemosporida |
| Family: |
Plasmodiidae |
| Genus: |
Plasmodium |
| Species: |
P. chabaudi |
| Binomial name |
Plasmodium chabaudi
|
Plasmodium chabaudi is a parasite of the genus Plasmodium subgenus Vinckeia.
Like all Plasmodium species P. chabaudi has both vertebrate and insect hosts. The vertebrate hosts for this parasite are rodents.[1]
Contents
- 1 Description
- 2 Genome
- 3 Geographical occurrence
- 4 Clinical features and host pathology
- 5 Notes
- 6 External links
- 7 References
Description
This species was described in 1965 by I. Landau.[2] It is named after Pr Alain Chabaud.
Genome
The nuclear genome is 18.8 megabases in size with a karyotype of 14 chromosomes. The G+C content is ~23%. A genome sequencing project is underway.
Geographical occurrence
This species is found in Africa. This species was first isolated from the blood of a shiny thicket rat (Thamnomys rutilans) in the Central African Republic.[3]
Clinical features and host pathology
While it is difficult to study P. chabaudi in its natural host given the difficulty of taming the thicket rat, it has been studied extensively in laboratory mice, largely using the clone P. chabaudi chabaudi (AS). The pathology resembles that of human malaria in that animals are susceptible to parasite growth and pathology such as anemia, hypoglycemia, changes in body temperature, weight loss, and occasional death. The other cloned strains vary in growth rates and virulence.[4] One unique feature of this species is its prolonged course of infection. While it seems to persist for years in the thicket rat, P. chabaudi (AS) lasts up to three months in BALB/c or C57Bl/6 mice [5] P. falciparum has been observed to persist for up to a year,[6] and even in conditions of drought when there are no new infections.[7] Other species that are used to model human infection do not have this property. The other unique properties of this parasite are that it is synchronous, as first described for malaria by Galen, and that it prefers to infect normocytes, similar to P. falciparum, the most virulent human parasite, while several of the other rodent parasites have a preference for immature red blood cells, or reticulocytes, which they share with P. vivax.
Notes
Two subspecies have been defined: P. chabaudi chabaudi and P. chabaudi adami.
External links
- GeneDB Plasmodium chabaudi
- Images of rodent malaria parasites at www.culleton.org
References
- ^ Hoffman, Stephen P. (1996). Malaria Vaccine Development: A Multi-Immune Response Approach. American Society Microbiology. ISBN 1-55581-111-6.
- ^ Landau I. (1965) Description de Plasmodium chabaudi n. sp., parasite de rongeurs africains. C. R. Hebd. Séances Acad. Sci. 260:3758-3761.
- ^ Trans R Soc Trop Med Hyg. 1966;60(5):633-49. Rodent plasmodia of the République Centrafricaine: the sporogony and tissue stages of Plasmodium chabaudi and P. berghei yoelii. Landau I, Killick-Kendrick R.
- ^ The contribution of Plasmodium chabaudi to our understanding of malaria. Stephens R, Culleton RL, Lamb TJ. Trends Parasitol. 2012 Feb;28(2):73-82. http://www.sciencedirect.com/science/article/pii/S147149221100184X
- ^ Parasite Immunol. 2007 Sep;29(9):435-44. Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi. Achtman AH1, Stephens R, Cadman ET, Harrison V, Langhorne J.
- ^ A retrospective examination of sporozoite-induced and trophozoite-induced infections with Plasmodium ovale: development of parasitologic and clinical immunity during primary infection. Collins WE, Jeffery GM. Am J Trop Med Hyg. 2002 May;66(5):492-502.
- ^ Characteristics of Plasmodium falciparum parasites that survive the lengthy dry season in eastern Sudan where malaria transmission is markedly seasonal. Babiker HA, Abdel-Muhsin AM, Ranford-Cartwright LC, Satti G, Walliker D. Am J Trop Med Hyg. 1998 Oct;59(4):582-90.
UpToDate Contents
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English Journal
- Macrophage Migration Inhibitory Factor: A Downregulator of Early T Cell-Dependent IFN-{gamma} Responses in Plasmodium chabaudi adami (556 KA)-Infected Mice.
- Malu DT, Belanger B, Desautels F, Kelendji K, Dalko E, Sanchez-Dardon J, Leng L, Bucala R, Satoskar AR, Scorza T.SourceDepartement des Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec H3B 3H5, Canada;
- Journal of immunology (Baltimore, Md. : 1950).2011 Jun 1;186(11):6271-9. Epub 2011 Apr 25.
- Neutralization of macrophage migration inhibitory factor (MIF) increases anti-tumor cytotoxic T cell responses in vivo and IFN-γ responses in vitro, suggesting a plausible regulatory role for MIF in T cell activation. Considering that IFN-γ production by CD4(+) T cells is pivotal to resolve murine
- PMID 21518974
- Signaling through the IL-2 receptor γ(c) peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria.
- Weidanz WP, Lafleur G, Kita-Yarbro A, Nelson K, Burns JM Jr.SourceMedical Microbiology & Immunology, University of Wisconsin, Madison, WI Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA.
- Parasite immunology.2011 May 18. doi: 10.1111/j.1365-3024.2011.01298.x. [Epub ahead of print]
- A genetic dissection approach was employed to determine whether the IL-2 receptor complex (IL-2R) comprised of α, β and γ chains is required for the suppression of Plasmodium chabaudi adami parasitemia. Blood-stage infections in IL-2Rγ ( c ) ( -/y ) mice failed to cure with parasitemia remaining
- PMID 21585397
Japanese Journal
- Characterization of immune responses to single or mixed infections with P. yoelii 17XL and P. chabaudi AS in different strains of mice
- Parasitology international : official journal of the Japanese Society of Parasitology 59(3), 400-406, 2010-09-01
- NAID 10029825337
- Evolution of antigenic gene families in the Plasmodium genus
- Evolution of antigenic gene families in the Plasmodium genus
Related Links
- Definition of Plasmodium chabaudi in the Medical Dictionary. Plasmodium chabaudi explanation. Information about Plasmodium chabaudi in Free online English dictionary. What is Plasmodium chabaudi? Meaning of Plasmodium ...
- P. chabaudi is one of the four malaria species that infect murine rodents from Central Africa that are infectious to laboratory rodents and easily maintained and transmitted by Anopheles stephensi in the laboratory. It ...
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- ラ
- Plasmodium yoelii、Plasmodium berghei、Plasmodium chabaudi
- 関
- プラスモディウム・ベルゲイ、プラスモディウム・シャバウディ、プラスモディウム・ヨエリ
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プラスモディウム・ベルゲイ、ネズミマラリア原虫
- 関
- Plasmodium chabaudi、Plasmodium yoelii
[★]
プラスモディウム・ヨエリ、ネズミマラリア原虫
- 関
- Plasmodium berghei、Plasmodium chabaudi
[★]
- ラ
- Plasmodium chabaudi
- 関
- ネズミマラリア原虫
[★]
プラスモディウム属