- 同
- phenyl isothiocyanate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/05 15:36:50」(JST)
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Phenyl isothiocyanate
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Names |
IUPAC name
Isothiocyanatobenzene
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Other names
Thiocarbanil
|
Identifiers |
CAS Registry Number
|
103-72-0 N |
ChemSpider |
7390 N |
InChI
-
InChI=1S/C7H5NS/c9-6-8-7-4-2-1-3-5-7/h1-5H N
Key: QKFJKGMPGYROCL-UHFFFAOYSA-N N
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InChI=1/C7H5NS/c9-6-8-7-4-2-1-3-5-7/h1-5H
Key: QKFJKGMPGYROCL-UHFFFAOYAC
|
Jmol-3D images |
Image |
PubChem |
7673 |
|
Properties |
Chemical formula
|
C7H5NS |
Molar mass |
135.19 g/mol |
Appearance |
Colorless liquid with a pungent odor[1] |
Density |
1.1288 g/cm3[1] |
Melting point |
−21 °C (−6 °F; 252 K) |
Boiling point |
221 °C (430 °F; 494 K) |
Solubility in water
|
negligible [1] |
Solubility |
ethanol, ether[2] |
Hazards |
Main hazards |
toxic, flammable[1] |
GHS pictograms |
[2] |
GHS signal word |
Danger[2] |
GHS hazard statements
|
H331, H311, H301, H314, H317, H334, H361[2] |
GHS precautionary statements
|
P301+310, P280, P312, P302+350, P301+330+331, P305+351+338, P310, P261, P304+341, P342+311, P280[2] |
EU classification |
T[2] |
R-phrases |
R23/24/25 R34 R42/43 R63[2] |
S-phrases |
S23 S26 S28 S36/37/39 S38 S45 [2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
N verify (what is: Y/N?) |
Infobox references |
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Phenyl isothiocyanate (PITC) is a reagent used in reversed phase HPLC. PITC is less sensitive than o-phthaldehyde (OPA) and cannot be fully automated. PITC can be used for analysing secondary amines, unlike OPA.
It is also known as Edman's reagent and is used in Edman degradation.
Commercially available, this compound may be synthesized by reacting aniline with carbon disulfide and concentrated ammonia to give the ammonium dithiocarbamate salt. Further reaction with lead(II) nitrate gives phenyl isothiocyanate:[3]
Another method of synthesizing involves a Sandmeyer reaction using aniline, sodium nitrite and copper(I) thiocyanate.
See also
- Isothiocyanate
- Naphthyl isothiocyanate
References
- ^ a b c d http://www.caslab.com/Phenyl_isothiocyanate_CAS_103-72-0/
- ^ a b c d e f g h i j http://www.chemexper.com/cheminfo/servlet/org.dbcreator.MainServlet?query=entry._entryID%3D1288243&target=entry&action=PowerSearch&format=google2008
- ^ F. B. Dains, R. Q. Brewster, and C. P. Olander. "Phenyl isothiocyanate". Org. Synth. ; Coll. Vol. 1, p. 447
English Journal
- Simultaneous determination of free amino acids in Pu-erh tea and their changes during fermentation.
- Zhu Y1, Luo Y2, Wang P1, Zhao M1, Li L1, Hu X1, Chen F3.
- Food chemistry.Food Chem.2016 Mar 1;194:643-9. doi: 10.1016/j.foodchem.2015.08.054. Epub 2015 Aug 18.
- Pu-erh ripened tea is produced through a unique microbial fermentation process from the sun-dried leaves of large-leaf tea species (Camellia sinensis (Linn.) var. assamica (Masters) Kitamura) in Yunnan province of China. In this study, the changes of amino acid profiles during fermentation of Pu-erh
- PMID 26471603
- The effectiveness of Routine Opt-out HIV Testing for children in Harare, Zimbabwe.
- Ferrand RA1, Meghji J, Kidia K, Dauya E, Bandason T, Mujuru H, Ncube G, Mungofa S, Kranzer K.
- Journal of acquired immune deficiency syndromes (1999).J Acquir Immune Defic Syndr.2015 Oct 12. [Epub ahead of print]
- OBJECTIVE: HIV testing is the entry point to access HIV care. For HIV-infected children who survive infancy undiagnosed, diagnosis usually occurs on presentation to health care services. We investigated the effectiveness of routine opt-out HIV testing (ROOT) compared to conventional opt-in provider-
- PMID 26473799
- Perceptions of Sudanese women of reproductive age toward HIV/AIDS and services for Prevention of Mother-to-Child Transmission of HIV.
- Elsheikh IE1,2, Crutzen R3, Van den Borne HW4.
- BMC public health.BMC Public Health.2015 Jul 17;15:674. doi: 10.1186/s12889-015-2054-1.
- BACKGROUND: Access to antenatal HIV testing during pregnancy and the level of uptake of services for Prevention of Mother-to-Child Transmission (PMTCT) in Sudan are very low. This study aimed to obtain insights into the perceptions of Sudanese pregnant women toward HIV/AIDS and the use of PMTCT serv
- PMID 26184881
Japanese Journal
- 愛知県におけるエイズ診療拠点病院初診患者の受診遅れと検査遅れに関連する要因
- 福山 由美,市川 誠一,大林 由美子 [他]
- 日本エイズ学会誌 = The journal of AIDS research 15(2), 119-127, 2013
- NAID 40019754278
- A manual sequence method of peptides and phosphopeptides using 4-(1'-cyanoisoindolyl)phenylisothiocyanate.
- Shibata Takayuki,Wainaina Moses N,Miyoshi Takayuki,Kabashima Tsutomu,Kai Masaaki
- Journal of Chromatography. A 1218(24), 3757-3762, 2011-06-17
- … Up to the 4th residue of phosphorylated pentapeptides was successfully identified, whereas phosphoamino acid residues could not be detected by the conventional procedure using phenylisothiocyanate (PITC). …
- NAID 120003220737
- わが国のHIV検査相談に関する一考察 : PITCの導入について
- 神田 浩路,新井 明日奈,大林 由英,紺野 圭太,加藤 真吾,玉城 英彦
- 日本エイズ学会誌 = The journal of AIDS research 13(2), 99-104, 2011-05-20
- NAID 10031161809
Related Links
- PITC Canvas SIZE:H36.5cm × W26cm 28,572円(税込30,857円) SIZE : Free 28,572円(税込30,857円) SIZE : Free 2,381円(税込2,571円) SIZE : Φ67mm × H145mm 4,286円(税込4,628円) Size:A4 / 156page 4,286円(税込4,628円) ...
- The Program for Infant/Toddler Care, PITC Skip to Content The Program for Infant/Toddler Care Graduate Profile Login Home Training Training of Trainers CA Trainer Institutes Overview Modules Institute Application Faculty Find a ...
Related Pictures
★リンクテーブル★
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- 英
- Edman reagent
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- フェニルイソチオシアネート phenyl isothiocyanate PITC
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- 英
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- 同
- PITC
- 関
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- 同
- PITC
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- 英
- PITC method
- 関
- エドマン分解
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フェニルイソチオシアネート法
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