関: See Prostaglandin H synthase

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/22 19:00:48」(JST)

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1. COX-2阻害剤および胃十二指腸障害：大規模臨床試験 cox 2 inhibitors and gastroduodenal toxicity major clinical trials
2. 非ステロイド性抗炎症剤（NSAIDs）：作用機序 nsaids mechanism of action
3. COX-2選択的阻害剤の概要 overview of selective cox 2 inhibitors

English Journal

EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells.

Hoffmann J, Junker H, Schmieder A, Venz S, Brandt R, Multhoff G, Falk W, Radons J.SourceInstitut für Medizinische Biochemie und Molekularbiologie, Ernst-Moritz-Arndt-Universität, D-17487 Greifswald, Germany.
Biochemical pharmacology.Biochem Pharmacol.2011 Nov 1;82(9):1153-62. Epub 2011 Jul 20.
Human pancreatic cancer is currently one of the fifth-leading causes of cancer-related mortality with a 5-year survival rate of less than 5%. Since pancreatic carcinoma is largely refractory to conventional therapies, there is a strong medical need for the development of novel and innovative therape
PMID 21787753

Dynamics of different arachidonic acid orientations bound to prostaglandin endoperoxide synthases.

Sachett LG, Verli H.SourceCentro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500, CP 15005, Porto Alegre 91500-970, RS, Brazil.
European journal of medicinal chemistry.Eur J Med Chem.2011 Oct;46(10):5212-7. Epub 2011 Aug 16.
Prostaglandin endoperoxide synthases (PGHSs) catalyze the conversion of arachidonic acid (AA) into prostaglandin endoperoxide H(2). This reaction requires a specific orientation of AA within the active site, but an alternative crystallographic binding orientation for AA also exists. Since the origin
PMID 21864948

Japanese Journal

Effect of Steroids on HOXA10 mRNA and Protein Expression and Prostaglandin Production in the Porcine Endometrium

BLITEK Agnieszka,KIEWISZ Jolanta,WACLAWIK Agnieszka,KACZMAREK Monika M.,ZIECIK Adam J.
The Journal of reproduction and development 56(6), 643-648, 2010-12-01
NAID 10027730375

Effect of Steroids on HOXA10 mRNA and Protein Expression and Prostaglandin Production in the Porcine Endometrium

Blitek Agnieszka,Kiewisz Jolanta,Waclawik Agnieszka [他],KACZMAREK Monika M.,ZIECIK Adam J.
Journal of Reproduction and Development 56(6), 643-648, 2010
… Moreover, <i>HOXA10</i>-dependent expression of prostaglandin H synthase-2 (PGHS-2), a key enzyme in prostaglandin production, has been previously detected. … on HOXA10 mRNA and protein content in the endometrium collected on day 9 of the estrous cycle and 2) determine the PGHS-2 protein expression and PGE<sub>2</sub> …
NAID 130000329055

Enhanced Release of Prostaglandin D_2 during Re-incubation of RAW 264.7 Macrophage-Like Cells after Treatment of Both Lipopolysaccharide and Non-steroidal Anti-inflammatory Drugs(Biochemistry/Molecular Biology)

Tanaka Yasuhito,Takizawa Makiko,Igimi Shizunobu [他],AMANO Fumio
Biological & pharmaceutical bulletin 27(7), 985-991, 2004-07-01
… This release was inhibited by non-steroidal anti-inflammatory drugs (NSAIDs), which are known to inhibit prostaglandin H_2 synthase (PGHS) activity. … In this study, we examined the effect of removal of NSAID after induction of PGHS with LPS, on the release of PCs, which has not been studied well. … Besides, PGHS activity was detectable in these cell homogenates and the amount of PGHS-2 protein showed similar changes to PGD_2 release. …
NAID 110003608900

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