関: Heligmosomoides polygyrus

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/17 15:34:26」(JST)

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Heligmosomoides polygyrus (formerly known as Nematospiroides dubius^[1]) is a common nematode found in the duodenum and small intestine of woodmice and other rodents.

They are 5–20mm in length and bright red due to the pigmentation of their tissues. They are usually heavily coiled, with the female having 12–15 coils and the male 8–12. The male can be distinguished from the female by a prominent copulatory bursa and two long, thin spicules at the posterior end.

They have a direct life cycle. The eggs pass out with the faeces of the host into the environment. After 2 days they hatch as larvae which are about 300μm in length. The larvae moult 3 days later but retain the shed cuticle for protection. It is at this point they become infective. The larvae shed the outer protective sheath after they are eaten by a suitable host. The larvae then penetrate the submucosa of the duodenum where they undergo 2 further molts. About 7 days later the male and female adult worms emerge into the lumen of the duodenum. They attach to the epithelial layer of the duodenum where they feed off the contents of the gut. The adult worms mate and eggs are shed in the feces. The complete life cycle from egg to egg takes a minimum of 15 days, and the female worms will live inside their host for 8 months.

These worms often form cysts in the wall of the intestine. These cysts often become infected with bacteria, but it is not yet known if these are harmful to the host.

This organism is often used to model human helminth infection in laboratory mice.

References

^ Wabo Poné, J.; Fossi Tankoua, O.; Yondo, J.; Komtangi, M. C.; Mbida, M.; Bilong Bilong, C. F. (2011). "The in Vitro Effects of Aqueous and Ethanolic Extracts of the Leaves of Ageratum conyzoides (Asteraceae) on Three Life Cycle Stages of the Parasitic Nematode Heligmosomoides bakeri (Nematoda: Heligmosomatidae)". Veterinary Medicine International 2011: 1. DOI:10.4061/2011/140293. edit

English Journal

Duodenal helminth infection alters barrier function of the colonic epithelium via adaptive immune activation.

Su CW, Cao Y, Kaplan J, Zhang M, Li W, Conroy M, Walker WA, Shi HN.SourceMucosal Immunology Laboratory, Massachusetts General Hospital, Building 114, 16th Street, Room 3504, Charlestown, MA 02129, USA.
Infection and immunity.Infect Immun.2011 Jun;79(6):2285-94. Epub 2011 Mar 28.
Chronic infection with intestinal helminth parasites is a major public health problem, particularly in the developing world, and can have significant effects on host physiology and the immune response to other enteric infections and antigens. The mechanisms underlying these effects are not well unde
PMID 21444669

A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection.

King IL, Mohrs K, Mohrs M.SourceTrudeau Institute, Saranac Lake, NY 12983, USA.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2010 Nov 15;185(10):6138-45. Epub 2010 Oct 6.
Pathogen-specific Ab production following infection with the gut-dwelling roundworm Heligmosomoides polygyrus is critical for protective immunity against reinfection. However, the factors required for productive T cell-B cell interactions in the context of a type 2-dominated immune response are not
PMID 20926797

Japanese Journal

Immunological relationships during Primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): down-regulation of specific cytokine secretion(IL-9and IL-10)correlates with poor mastocytosis and chronic survival of adult worms

BHNKE JM.
Parasite Immunol 15, 415-421, 1993
NAID 30029944000

Heligmosomoides polygyrus or Nematospiroides dubius?

BEHNKE JM.
Parasitol Today 7, 177-179, 1991
NAID 30003535638

Related Pictures

★リンクテーブル★

リンク元	「ネマトスピロイデス・ドゥビウス」「Heligmosomoides polygyrus」
関連記事	「Nematospiroides」

「ネマトスピロイデス・ドゥビウス」

Heligmosomoides polygyrus
	Female H. polygyrus from the digestive tractus of a woodmouse
Scientific classification
Kingdom:	Animalia
Phylum:	Nematoda
Class:	Chromadorea
Order:	Rhabditida
Family:	Heligmosomidae
Genus:	Heligmosomoides
Species:	H. polygyrus
Binomial name
	Heligmosomoides polygyrus;

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ラ: Nematospiroides dubius
関: ヘリグモソモイデス・・リギルス

「Heligmosomoides polygyrus」

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ヘリグモソモイデス・・リギルス

関: Nematospiroides dubius

「Nematospiroides」

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ネマトスピロイデス属、Nematospiroides属

[0] Wabo Poné, J.; Fossi Tankoua, O.; Yondo, J.; Komtangi, M. C.; Mbida, M.; Bilong Bilong, C. F. (2011). "The in Vitro Effects of Aqueous and Ethanolic Extracts of the Leaves of Ageratum conyzoides (Asteraceae) on Three Life Cycle Stages of the Parasitic Nematode Heligmosomoides bakeri (Nematoda: Heligmosomatidae)". Veterinary Medicine International 2011: 1. DOI:10.4061/2011/140293. edit

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案内

Nematospiroides dubius