English Journal

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.

Zaiss MM1, Rapin A1, Lebon L1, Dubey LK1, Mosconi I1, Sarter K2, Piersigilli A3, Menin L4, Walker AW5, Rougemont J6, Paerewijck O7, Geldhof P7, McCoy KD8, Macpherson AJ8, Croese J9, Giacomin PR10, Loukas A10, Junt T11, Marsland BJ12, Harris NL13.
Immunity.Immunity.2015 Nov 17;43(5):998-1010. doi: 10.1016/j.immuni.2015.09.012. Epub 2015 Oct 27.
Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or whether it also involved crosstalk with the l
PMID 26522986

Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T- and B cell-independent, but is associated with reduced innate lymphoid cell activation.

McSorley HJ1, Blair NF2, Robertson E2, Maizels RM2.
Experimental parasitology.Exp Parasitol.2015 Nov;158:8-17. doi: 10.1016/j.exppara.2015.02.009. Epub 2015 Feb 26.
The murine intestinal nematode Heligmosomoides polygyrus exerts multiple immunomodulatory effects in the host, including the suppression of allergic inflammation in mice sensitized to allergen presented with alum adjuvant. Similar suppression is attained by co-administration of H. polygyrus excretor
PMID 25728231

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection.

Mosconi I1, Dubey LK1, Volpe B1, Esser-von Bieren J1, Zaiss MM1, Lebon L1, Massacand JC1, Harris NL2.
Infection and immunity.Infect Immun.2015 Sep;83(9):3657-65. doi: 10.1128/IAI.00266-15. Epub 2015 Jul 6.
Helminth infections are typically chronic in nature; however, the exact molecular mechanisms by which these parasites promote or thwart host immunity remain unclear. Worm expulsion requires the differentiation of CD4(+) T cells into Th2 cells, while regulatory T cells (Tregs) act to dampen the exten
PMID 26150538

Japanese Journal

Immunological relationships during Primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): down-regulation of specific cytokine secretion(IL-9and IL-10)correlates with poor mastocytosis and chronic survival of adult worms