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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/09 13:39:33」(JST)

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Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. It is a prodrug of the free form mometasone (INN).

Uses, administration, and pharmacodynamics

Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma^[2]^[3] for patients unresponsive to less potent corticosteroids, and penile phimosis.^[4] In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.^[5]

It reduces inflammation by causing several effects:^[6]^[7]^[8]

reversing the activation of inflammatory proteins
activating the secretion of anti-inflammatory proteins
stabilizing cell membranes
decreasing the influx of inflammatory cells

The exact anti-inflammatory mechanism of action is unknown.

Availability

Merck markets the medication under the following brand names; Elocon (Elocom, Elomet, Elosalic), Elica and Novasone as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions. Essex pharma markets the medication under the brand name Ecural and Progreś Laboratories markets it under mometAid. It is also marketed by Perrigo as an ointment for the scalp.In India it is marketed by Intas under the trade name 'Eziwin'.

It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa under the brand name Mometamax.^[9]

References

^ Zia R Tayab, Tom C Fardon, Daniel K C Lee, Kay Haggart, Lesley C McFarlane, Brian J Lipworth, and Günther Hochhaus (November 2007). "Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate". Br J Clin Pharmacol 64 (5): 698–705. doi:10.1111/j.1365-2125.2007.02919.x. PMC 2203259. PMID 17509041.
^ Tan RA, Corren J (December 2008). "Mometasone furoate in the management of asthma: a review". Ther Clin Risk Manag 4 (6): 1201–8. PMC 2643101. PMID 19337427.
^ Bousquet J (May 2009). "Mometasone furoate: an effective anti-inflammatory with a well-defined safety and tolerability profile in the treatment of asthma". Int. J. Clin. Pract. 63 (5): 806–19. doi:10.1111/j.1742-1241.2009.02003.x. PMID 19392928.
^ Khope S (March 2010). "Topical mometasone furoate for phimosis". Indian pediatr 47 (3): 282. PMID 20371899.
^ Williams D. What does potency actually mean for inhaled corticosteroids?. The Journal Of Asthma: Official Journal Of The Association For The Care Of Asthma [serial online]. July 2005;42(6):409-417. Available from: MEDLINE with Full Text, Ipswich, MA. Accessed October 25, 2011.
^ Product Information: NASONEX(R) nasal spray, mometasone furoate monohydrate nasal spray. Schering Corporation, Kenilworth, NJ, 2010.
^ Publishers, Jones and Bartlett (2009-07-15). Nurse's Drug Handbook 2010. p. 677. ISBN 978-0-7637-7900-9.
^ Mani S. Kavuru (2007). "ch. 9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 978-1-932610-38-3.
^ "Mometamax". Intervet USA. Retrieved 19 June 2010.

External links

Mometasone Furoate Oral Inhalation (MedlinePlus)
Mometasone Furoate Nasal Inhalation (MedlinePlus)
Nasonex Home page
Asmanex Home page
Elica Home page
U.S. National Library of Medicine: Drug Information Portal - Mometasone furoate

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 慢性的な手の湿疹 chronic hand eczema
2. 味覚および嗅覚障害の評価および治療 evaluation and treatment of taste and smell disorders
3. Chronic rhinosinusitis: Management
4. Vitiligo: Management and prognosis
5. 吸入ステロイドの主な副作用 major side effects of inhaled glucocorticoids

English Journal

Mometasone furoate hydrogel for scalp use: in vitro and in vivo evaluation.

Salgado A1, Raposo S, Marto J, Silva AN, Simões S, Ribeiro HM.
Pharmaceutical development and technology.Pharm Dev Technol.2014 Aug;19(5):618-22. doi: 10.3109/10837450.2013.819012. Epub 2013 Jul 22.
Dermatological inflammatory diseases often affect the scalp and the eyebrows. Common dosage forms available on the market for those situations are lotions; however, the presence of hair limits their use. Gels, for their consistency and adhesiveness, are a suitable alternative to the lotions in these
PMID 23869426

Low-frequency shift dispersive Raman spectroscopy for the analysis of respirable dosage forms.

Wang H1, Boraey MA1, Williams L2, Lechuga-Ballesteros D2, Vehring R3.
International journal of pharmaceutics.Int J Pharm.2014 Jul 20;469(1):197-205. doi: 10.1016/j.ijpharm.2014.04.058. Epub 2014 May 1.
A high performance Raman system equipped with a CCD (charged coupled device) sensor and recently developed optical filter technology is described. It provides high sensitivity, high resolution, and access to low-frequency vibrations enabling resolution of spectral features due to lattice vibrational
PMID 24793839

Structures and mechanism for the design of highly potent glucocorticoids.

He Y1, Yi W2, Suino-Powell K1, Zhou XE1, Tolbert WD1, Tang X2, Yang J3, Yang H3, Shi J2, Hou L2, Jiang H3, Melcher K1, Xu HE4.
Cell research.Cell Res.2014 Jun;24(6):713-26. doi: 10.1038/cr.2014.52. Epub 2014 Apr 25.
The evolution of glucocorticoid drugs was driven by the demand of lowering the unwanted side effects, while keeping the beneficial anti-inflammatory effects. Potency is an important aspect of this evolution as many undesirable side effects are associated with use of high-dose glucocorticoids. The si
PMID 24763108

Japanese Journal

イネ科花粉症に対するモメタゾンフランカルボン酸エステル水和物点鼻液の治療効果

太田伸男,鈴木祐輔,青柳優
耳鼻咽喉科臨床 103(12), 1147-1155, 2010-12-01
We studied the clinical effects of mometasone furoate on subjects with seasonal grass pollinosis by comparing nasal and ocular symptom scores, medication scores and symptom-medication scores before an …
NAID 10027449773

Once-daily mometa-sone furoate aqueous nasal spray (Nasonex)in seasonal allergic rhinitis; an active-and placebo-controlled study

HEBERT Jr
Allergy 51, 569-576, 1996
NAID 30036938014

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「モメタゾン」

Mometasone furoate
Systematic (IUPAC) name
	(11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate
Clinical data
Trade names	Elocon Elocom, Elomet, Elosalic Novasone Nasonex Asmanex Twisthaler Essex pharma markets the medication under the brand name Ecural mometAid.
AHFS/Drugs.com	monograph
Pregnancy cat.	C (US)
Legal status	Rx Only (US)
Routes	topical, inhalation
Pharmacokinetic data
Bioavailability	Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.
Protein binding	98% to 99%
Metabolism	hepatic
Half-life	5.8 hours
Identifiers
CAS number	105102-22-5 83919-23-7
ATC code	D07AC13 R01AD09, R03BA07
PubChem	CID 441336
DrugBank	DB00764
ChemSpider	390091
ChEBI	CHEBI:47564
ChEMBL	CHEMBL1161
Synonyms	(9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
Chemical data
Formula	C22H28Cl2O4 for Mometasone; C27H30O6Cl2 as Furoate
Mol. mass	427.361 g/mol (Mometasone); 521.4 g/mol (Furoate)
	SMILES O=C(O[C@]2(C(=O)CCl)[C@H](C)C[C@H]3[C@@H]4CCC\1=C\C(=O)\C=C/[C@]/1(C)[C@@]4(Cl)[C@@H](O)C[C@]23C)c5occc5;
	InChI InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1 ; Key:WOFMFGQZHJDGCX-ZULDAHANSA-N ;
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　　[★]

英: mometasone
化: フランカルボン酸モメタゾン、フロ酸モメタゾン mometasone furoate、フロ酸モメタゾン水和物 mometasone furoate hydrate、フランカルボン酸モメタゾン水和物
商: アズマネックス、ナゾネックス、フランカルボン酸モメタゾン、フルメタ、マイセラ。Nasonex
関: その他の呼吸器官用薬、耳鼻科用剤

糖質コルチコイド;強力な抗炎症作用;外用

[1] Zia R Tayab, Tom C Fardon, Daniel K C Lee, Kay Haggart, Lesley C McFarlane, Brian J Lipworth, and Günther Hochhaus (November 2007). "Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate". Br J Clin Pharmacol 64 (5): 698–705. doi:10.1111/j.1365-2125.2007.02919.x. PMC 2203259. PMID 17509041.

[pmid19337427-2] Tan RA, Corren J (December 2008). "Mometasone furoate in the management of asthma: a review". Ther Clin Risk Manag 4 (6): 1201–8. PMC 2643101. PMID 19337427.

[pmid19392928-3] Bousquet J (May 2009). "Mometasone furoate: an effective anti-inflammatory with a well-defined safety and tolerability profile in the treatment of asthma". Int. J. Clin. Pract. 63 (5): 806–19. doi:10.1111/j.1742-1241.2009.02003.x. PMID 19392928.

[pmid20371899-4] Khope S (March 2010). "Topical mometasone furoate for phimosis". Indian pediatr 47 (3): 282. PMID 20371899.

[5] Williams D. What does potency actually mean for inhaled corticosteroids?. The Journal Of Asthma: Official Journal Of The Association For The Care Of Asthma [serial online]. July 2005;42(6):409-417. Available from: MEDLINE with Full Text, Ipswich, MA. Accessed October 25, 2011.

[6] Product Information: NASONEX(R) nasal spray, mometasone furoate monohydrate nasal spray. Schering Corporation, Kenilworth, NJ, 2010.

[7] Publishers, Jones and Bartlett (2009-07-15). Nurse's Drug Handbook 2010. p. 677. ISBN 978-0-7637-7900-9.

[8] Mani S. Kavuru (2007). "ch. 9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 978-1-932610-38-3.

[9] "Mometamax". Intervet USA. Retrieved 19 June 2010.

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