- 同
- nodular lymphocyte-predominant Hodgkin lymphoma
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/30 15:59:01」(JST)
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| Nodular lymphocyte predominant Hodgkin's lymphoma |
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Micrograph of a lymph node biopsy showing nodular lymphocyte predominant Hodgkin lymphoma, with the Reed–Sternberg cell variant that has a popcorn-shaped nucleus (left-bottom of image). H&E stain.
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| Classification and external resources |
| Specialty |
Hematology and oncology |
| ICD-10 |
C81.0 |
| ICD-9-CM |
201.9 |
| ICD-O |
M9659/3 |
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[edit on Wikidata]
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Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a form of lymphoma.[1][2]
Hodgkin lymphoma, nodular lymphocyte predominant (low power view). Notice the nodular architecture and the areas of "mottling".(H&E)
Hodgkin lymphoma, nodular lymphocyte predominant (high power view). Notice the presence of L&H cells, also known as "popcorn cells". (H&E)
Some people no longer classified it as a form of classic Hodgkin's lymphoma (HL). This is because the Reed-Sternberg Cell (RSC) variants (popcorn cells) that characterize this form of the disease invariably express B lymphocyte markers such as CD20 (thus making NLPHL an unusual form of B cell lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma.
There are small but clear differences in prognosis between the various forms. Lymphocyte predominant HL is an uncommon subtype composed of vague nodules of numerous reactive lymphocytes admixed with large popcorn-shaped RSC. Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. The anti-CD20 monoclonal antibody Rituximab has been used in lymphocyte predominant Hodgkin's lymphoma with encouraging results.[3]
BCL6 gene rearrangements have been frequently observed.[4][5]
See also
- Progressive transformation of germinal centers
References
- ^ Renné C, Martín-Subero JI, Hansmann ML, Siebert R (August 2005). "Molecular Cytogenetic Analyses of Immunoglobulin Loci in Nodular Lymphocyte Predominant Hodgkin's Lymphoma Reveal a Recurrent IGH-BCL6 Juxtaposition". J Mol Diagn 7 (3): 352–6. doi:10.1016/S1525-1578(10)60564-8. PMC 1867541. PMID 16049307.
- ^ Achten R, Verhoef G, De Wolf-Peeters C (December 2003). "The importance of follow-up biopsies of clinically suspicious lymphadenopathy in nodular lymphocyte predominant Hodgkin's lymphoma". Haematologica 88 (12): 1431–2. PMID 14688002.
- ^ Saini KS, Azim HA Jr, Cocorocchio E, Vanazzi A, Saini ML, Raviele PR, Pruneri G, Peccatori FA (2011). "Rituximab in Hodgkin lymphoma: Is the target always a hit?". Cancer Treat Rev 37 (5): 385–90. doi:10.1016/j.ctrv.2010.11.005. PMID 21183282.
- ^ Wlodarska I, Stul M, De Wolf-Peeters C, Hagemeijer A (August 2004). "Heterogeneity of BCL6 rearrangements in nodular lymphocyte predominant Hodgkin's lymphoma". Haematologica 89 (8): 965–72. PMID 15339680.
- ^ Wlodarska I, Nooyen P, Maes B, et al. (January 2003). "Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma". Blood 101 (2): 706–10. doi:10.1182/blood-2002-05-1592. PMID 12393409.
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Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
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B cell
(lymphoma,
leukemia)
(most CD19
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By
development/
marker |
| TdT+ |
- ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
|
|
| CD5+ |
- naive B cell (CLL/SLL)
- mantle zone (Mantle cell)
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| CD22+ |
- Prolymphocytic
- CD11c+ (Hairy cell leukemia)
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|
| CD79a+ |
- germinal center/follicular B cell (Follicular
- Burkitt's
- GCB DLBCL
- Primary cutaneous follicle center lymphoma)
- marginal zone/marginal zone B-cell (Splenic marginal zone
- MALT
- Nodal marginal zone
- Primary cutaneous marginal zone lymphoma)
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| RS (CD15+, CD30+) |
- Classic Hodgkin's lymphoma (Nodular sclerosis)
- CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
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PCDs/PP
(CD38+/CD138+) |
- see immunoproliferative immunoglobulin disorders
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|
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| By infection |
- KSHV (Primary effusion)
- EBV (Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder)
- HIV (AIDS-related lymphoma)
- Helicobacter pylori (MALT lymphoma)
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| Cutaneous |
- Diffuse large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous immunocytoma
- Plasmacytoma
- Plasmacytosis
- Primary cutaneous follicle center lymphoma
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|
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| T/NK |
T cell
(lymphoma,
leukemia)
(most CD3
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By
development/
marker |
- TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
- prolymphocyte (Prolymphocytic)
- CD30+ (Anaplastic large-cell lymphoma
- Lymphomatoid papulosis type A)
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| Cutaneous |
| MF+variants |
- indolent: Mycosis fungoides
- Pagetoid reticulosis
- Granulomatous slack skin
aggressive: Sézary disease
- Adult T-cell leukemia/lymphoma
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| Non-MF |
- CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lymphomatoid papulosis type B
- CD30+: CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large-cell lymphoma
- Lymphomatoid papulosis type A
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|
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Other
peripheral |
- Hepatosplenic
- Angioimmunoblastic
- Enteropathy-associated T-cell lymphoma
- Peripheral T-cell lymphoma not otherwise specified (Lennert lymphoma)
- Subcutaneous T-cell lymphoma
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| By infection |
- HTLV-1 (Adult T-cell leukemia/lymphoma)
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NK cell/
(most CD56) |
- Aggressive NK-cell leukemia
- Blastic NK cell lymphoma
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| T or NK |
- EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
- Large granular lymphocytic leukemia
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Lymphoid+
myeloid |
- Acute biphenotypic leukaemia
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| Lymphocytosis |
- Lymphoproliferative disorders (X-linked lymphoproliferative disease
- Autoimmune lymphoproliferative syndrome)
- Leukemoid reaction
- Diffuse infiltrative lymphocytosis syndrome
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| Cutaneous lymphoid hyperplasia |
- Cutaneous lymphoid hyperplasia
- with bandlike and perivascular patterns
- with nodular pattern
- Jessner lymphocytic infiltrate of the skin
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UpToDate Contents
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English Journal
- Patterns of growth factor usage and febrile neutropenia among older patients with diffuse large B-cell non-Hodgkin lymphoma treated with CHOP or R-CHOP: the Intergroup experience (CALGB 9793; ECOG-SWOG 4494).
- Morrison VA1,2, Weller EA3, Habermann TM4, Li S3, Fisher RI5, Cheson BD6, Peterson BA7.
- Leukemia & lymphoma.Leuk Lymphoma.2017 Aug;58(8):1814-1822. doi: 10.1080/10428194.2016.1265111. Epub 2016 Dec 14.
- PMID 27967294
- Recent advances and future directions in mantle cell lymphoma research: report of the 2016 mantle cell lymphoma consortium workshop.
- Kahl BS1, Dreyling M2, Gordon LI3, Quintanilla-Martinez L4, Sotomayor EM5.
- Leukemia & lymphoma.Leuk Lymphoma.2017 Jul;58(7):1561-1569. doi: 10.1080/10428194.2017.1283036. Epub 2017 Jan 31.
- PMID 28140709
- Retrospective analysis of bendamustine and rituximab use in indolent and mantle cell non-Hodgkin lymphoma based on initial starting dose.
- Bond DA1, Huang Y2, Ruppert AS2, Walker AR2, Dotson EK3, Roddy J3, Blum KA2, Christian BA2.
- Leukemia & lymphoma.Leuk Lymphoma.2017 Jul;58(7):1589-1597. doi: 10.1080/10428194.2016.1253835. Epub 2016 Nov 14.
- PMID 27838951
Japanese Journal
- 岩崎 稔,山本 栄司,上村 良,花房 徹兒
- 日本小児外科学会雑誌 41(6), 810-814, 2005-10-20
- … MRI検査にて, 悪性疾患が示唆され, 精査・加療目的にて腫瘤摘出術を施行した.摘出標本の病理検査および免疫組織学的評価にて, 結節性リンパ球優位性ホジキンリンパ腫(Nodular lymphocyte predominant Hodgkin lymphoma : NLPHL)と診断された症例を経験したので報告する.摘出標本はリンパ節で, 主として小型のリンパ球のvague nodular pattern〜diffuse patternを示す増生が見られ, 小結節の内外に大型のvesicularで時に分葉を示すpopcorn …
- NAID 10016793710
- P-143 結節性リンパ球優位性ホジキンリンパ腫の1例 : Nodular lymphocyte predominant Hodgkin lymphoma : NLPHL(腫瘍3)
Related Links
- 臨床）NLPHLはホジキンリンパ腫の2-6％を占め、男女比は3:1と男性に多く、年齢の 中央値は35歳と30-40歳代にピークが見られます。表在性リンパ節腫大（頚部、腋窩 部 、そけい部）が多く、病期はⅠ期症例が半数以上を占めます。時に腹部大動脈周囲、 ...
- Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a type of Hodgkin's disease with excellent outcomes. Find out more about this lymphoma.
Related Pictures
★リンクテーブル★
[★]
- 英
- nodular lymphocyte-predominant Hodgkin lymphoma, NLPHL
- 関
- ホジキンリンパ腫
参考
- http://www.med.osaka-cu.ac.jp/labmed/page106.html