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1. アフリカトリパノソーマ症：臨床症状、診断、治療african trypanosomiasis clinical manifestations diagnosis and treatment [show details]
… Antigen detection enzyme-linked immunosorbent assay (ELISA) techniques for detection of trypanosomal antigens have been developed but are… monotherapy (400 mg/kg/day intravenously every 6 hours for 14 days) or eflornithine (400 mg/kg/day intravenously every…consists of melarsoprol; eflornithine has no activity. Data on the use of melarsoprol for treatment of T. b. rhodesiense infection are limited; more data are available on the use of melarsoprol for treatment…
2. 抗原虫治療antiprotozoal therapies [show details]
…availability is very limited. Melarsoprol is a trivalent arsenical compound used to treat late-stage African trypanosomiasis involving the central nervous system . Melarsoprol appears to act by binding to …
3. ヒ素曝露と中毒arsenic exposure and poisoning [show details]
…syphilis (arsphenamine) and skin conditions (Fowler solution) and presently to treat trypanosomiasis (melarsoprol) and acute promyelocytic leukemia (arsenic trioxide) Chronic exposures to arsenic can occur…
4. 前立腺特異抗原の測定measurement of prostate specific antigen [show details]
… Prostate-specific antigen (PSA) is a glycoprotein that is expressed by both normal and neoplastic prostate tissue.… analytic variation in PSA was approximately 6 percent and the average biologic variation was less than 14 percent . A change in PSA of more than 30 percent in men with a PSA initially below 2.0 ng/mL was likely …
5. 炭疽菌の微生物学、病因、および疫学microbiology pathogenesis and epidemiology of anthrax [show details]
…poly-D-glutamic acid capsule and three proteins (edema factor [EF], lethal factor [LF], and protective antigen [PA]) . Virulence is enhanced by the cell surface protein BslA, which mediates adhesion to host cells … Antibodies to PA and LF were present in approximately 40 and 14 percent of unvaccinated individuals,…

English Journal

Neutrophil-Mediated Delivery of Dexamethasone Palmitate-Loaded Liposomes Decorated with a Sialic Acid Conjugate for Rheumatoid Arthritis Treatment.

Hu L, Luo X, Zhou S, Zhu J, Xiao M, Li C, Zheng H, Qiu Q, Lai C, Liu X, Deng Y, Song Y.
Pharmaceutical research. 2019 May;36(7)97.
The aim of this research was to design dexamethasone palmitate (DP) loaded sialic acid modified liposomes, with the eventual goal of using peripheral blood neutrophils (PBNs) that carried drug-loaded liposomes to improve the therapeutic capacity for rheumatoid arthritis (RA). A sialic acid - cholest
PMID 31076925

Impact of real-time shedding on binding kinetics of membrane-remaining L-selectin to PSGL-1.

Peng S, Chen SB, Li LD, Tong CF, Li N, Lü SQ, Long M.
American journal of physiology. Cell physiology. 2019 May;316(5)C678-C689.
L-selectin shedding induced by various cytokines is crucial in activating neutrophils (PMNs) in inflammatory cascade. While the real-time shedding in vivo lasts ~10 min after PMN activation, the impact of time-dependent shedding on binding kinetics of membrane-remaining L-selectins to its ligands is
PMID 30726114

Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α.

Goldberg R, Scotta C, Cooper D, Nissim-Eliraz E, Nir E, Tasker S, Irving PM, Sanderson J, Lavender P, Ibrahim F, Corcoran J, Prevost T, Shpigel NY, Marelli-Berg F, Lombardi G, Lord GM.
Gastroenterology. 2019 05;156(6)1775-1787.
Crohn's disease (CD) is characterized by an imbalance of effector and regulatory T cells in the intestinal mucosa. The efficacy of anti-adhesion therapies led us to investigate whether impaired trafficking of T-regulatory (Treg) cells contributes to the pathogenesis of CD. We also investigated wheth
PMID 30710527

Japanese Journal

Cytokines, Adhesion Molecules, and Immune Deviation in Autoimmune Salivary Gland Disease

Hayashi Yoshio
Oral Medicine & Pathology 1(1), 3-10, 1996
… and tumor necrosis factor(TNF)-α, interferon(IFN)-γ, IL-6, IL-10, IL-12(p40) was detected in the salivary gland, and the up-regulation of ICAM-1, LFA-1, CD44, Mel-14 mRNA was found in accordance with autoimmune sialadenitis. … In addition, we have analysed the expressionn of T cell antigen receptor(TCR)V β …
NAID 110002985147

Lymphocyte activation and regulation of three adhesion molecules with supposed function in homing : LECAM-1 (MEL-14 antigen) LPAM-1/2 (α4-integrin) and CD44 (Pgp-1)