関: Listeria meningoencephalitis、Listeria monocytogenes meningitis

WordNet

infectious disease characterized by inflammation of the meninges (the tissues that surround the brain or spinal cord) usually caused by a bacterial infection; symptoms include headache and stiff neck and fever and nausea
English surgeon who was the first to use antiseptics (1827-1912) (同)Joseph_Lister, Baron Lister
any species of the genus Listeria

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脳膜炎

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/26 15:17:14」(JST)

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Listeria is a genus of bacteria that, until 1992, contained 10 known species,^[1]^[2] each containing two subspecies. As of 2014, another five species were identified.^[3] Named after the British pioneer of sterile surgery Joseph Lister, the genus received its current name in 1940. Listeria species are gram-positive, rod-shaped, and facultatively anaerobic, and do not produce endospores.^[4] The major human pathogen in the Listeria genus is L. monocytogenes. It is usually the causative agent of the relatively rare bacterial disease listeriosis, a serious infection caused by eating food contaminated with the bacteria. The disease affects pregnant women, newborns, adults with weakened immune systems, and the elderly.

Listeriosis is a serious disease for humans; the overt form of the disease has a case-fatality rate around 20%. The two main clinical manifestations are sepsis and meningitis. Meningitis is often complicated by encephalitis, when it is known as meningoencephalitis, a pathology that is unusual for bacterial infections. L. ivanovii is a pathogen of mammals, specifically ruminants, and has rarely caused listeriosis in humans.^[5] The incubation period can vary between 3 and 70 days.^[6]

Background

The first documented case of listeriosis was in 1924. In the late 1920s, two researchers independently identified L. monocytogenes from animal outbreaks. They proposed the genus Listerella in honor of surgeon and early antiseptic advocate Joseph Lister, but that name was already in use for a slime mold and a protozoan. Eventually, the genus Listeria was proposed and accepted. All species within the Listeria genus are gram-positive, catalase-positive rods and do not produce endospores. The genus Listeria was classified in the family Corynebacteriaceae through the seventh edition of Bergey's Manual of Systematic Bacteriology. The 16S rRNA cataloging studies of Stackebrandt, et al. demonstrated that L. monocytogenes is a distinct taxon within the Lactobacillus-Bacillus branch of the bacterial phylogeny constructed by Woese. In 2004, the genus was placed in the newly created family Listeriaceae. The only other genus in the family is Brochothrix.^[7]

The genus Listeria currently contains 17 species: L. aquatica, L. booriae, L. cornellensis, L. fleischmannii, L. floridensis, L. grandensis, L. grayi, L. innocua, L. ivanovii, L. marthii, L. monocytogenes, L. newyorkensis, L. riparia, L. rocourtiae, L. seeligeri, L. weihenstephanensis, and L. welshimeri.^[8] Listeria dinitrificans, previously thought to be part of the Listeria genus, was reclassified into the new genus Jonesia.^[9] Under the microscope, Listeria species appear as small rods, which are sometimes arranged in short chains. In direct smears, they may be coccoid, so they can be mistaken for streptococci. Longer cells may resemble corynebacteria. Flagella are produced at room temperature, but not at 37°C. Hemolytic activity on blood agar has been used as a marker to distinguish L. monocytogenes from other Listeria species, but it is not an absolutely definitive criterion. Further biochemical characterization may be necessary to distinguish between the different species of Listeria.

Listeria can be found in soil, which can lead to vegetable contamination. Animals can also be carriers. Listeria has been found in uncooked meats, uncooked vegetables, fruit such as cantaloupes^[10] and apples,^[11] pasteurized or unpasteurized milk, foods made from milk, and processed foods. Pasteurization and sufficient cooking kill Listeria; however, contamination may occur after cooking and before packaging. For example, meat-processing plants producing ready-to-eat foods, such as hot dogs and deli meats, must follow extensive sanitation policies and procedures to prevent Listeria contamination.^[12] Listeria monocytogenes is commonly found in soil, stream water, sewage, plants, and food.^[13] Listeria is responsible for listeriosis, a rare but potentially lethal foodborne illness. The case fatality rate for those with a severe form of infection may approach 25%.^[14] (Salmonellosis, in comparison, has a mortality rate estimated at less than 1%.^[15]) Although L. monocytogenes has low infectivity, it is hardy and can grow in temperatures from 4°C (39.2°F) (the temperature of a refrigerator) to 37°C (98.6°F), (the body's internal temperature).^[13] Listeriosis is a serious illness, and the disease may manifest as meningitis, or affect newborns due to its ability to penetrate the endothelial layer of the placenta.^[14]

Pathogenesis

Listeria uses the cellular machinery to move around inside the host cell. It induces directed polymerization of actin by the ActA transmembrane protein, thus pushing the bacterial cell around.^[16]

L. monocytogenes, for example, encodes virulence genes that are thermoregulated. The expression of virulence factor is optimal at 39°C, and is controlled by a transcriptional activator, PrfA, whose expression is thermoregulated by the PrfA thermoregulator UTR element. At low temperatures, the PrfA transcript is not translated due to structural elements near the ribosome binding site. As the bacteria infect the host, the temperature of the host melts the structure and allows translation initiation for the virulent genes.

The majority of Listeria bacteria are targeted by the immune system before they are able to cause infection. Those that escape the immune system's initial response, however, spread through intracellular mechanisms and are, therefore, guarded against circulating immune factors (AMI).^[14]

To invade, Listeria induces macrophage phagocytic uptake by displaying D-galactose in their teichoic acids that are then bound by the macrophage's polysaccharide s. Other important adhesins are the internalins.^[15] Listeria uses internalin A and B to bind to cellular receptors. Internalin A binds to E-cadherin, while internalin B binds to the cell's Met receptors. If both of these receptors have a high enough affinity to Listeria's internalin A and B, then it will be able to invade the cell via an indirect zipper mechanism.^{[citation needed]} Once phagocytosed, the bacterium is encapsulated by the host cell's acidic phagolysosome organelle.^[13] Listeria, however, escapes the phagolysosome by lysing the vacuole's entire membrane with secreted hemolysin,^[17] now characterized as the exotoxin listeriolysin O.^[13] The bacteria then replicate inside the host cell's cytoplasm.^[14]

Listeria must then navigate to the cell's periphery to spread the infection to other cells. Outside the body, Listeria has flagellar-driven motility, sometimes described as a "tumbling motility". However, at 37°C, flagella cease to develop and the bacterium instead usurps the host cell's cytoskeleton to move.^[14] Listeria, inventively, polymerizes an actin tail or "comet",^[17] from actin monomers in the host's cytoplasm^[18] with the promotion of virulence factor ActA.^[14] The comet forms in a polar manner^[19] and aids the bacterial migration to the host cell's outer membrane. Gelsolin, an actin filament severing protein, localizes at the tail of Listeria and accelerates the bacterium's motility.^[19] Once at the cell surface, the actin-propelled Listeria pushes against the cell's membrane to form protrusions called filopods^[13] or "rockets". The protrusions are guided by the cell's leading edge^[20] to contact adjacent cells, which then engulf the Listeria rocket and the process is repeated, perpetuating the infection.^[14] Once phagocytosed, the bacterium is never again extracellular: it is an intracellular parasite^[17] like S. flexneri, Rickettsia spp., and C. trachomatis.^[14]

Epidemiology

The Center for Science in the Public Interest has published a list of foods that have sometimes caused outbreaks of Listeria: hot dogs, deli meats, pasteurized or unpasteurized milk, cheeses (particularly soft-ripened cheeses such as feta, Brie, Camembert, blue-veined, or Mexican-style queso blanco), raw and cooked poultry, raw meats, ice cream, raw fruit,^[21] vegetables, and smoked fish.^[22] Improperly handled cantaloupe was implicated in the outbreak of listeriosis from Jensen Farms in Colorado,^[23] and the Australian company GMI Food Wholesalers was fined A$236,000 for providing L. monocytogenes-contaminated chicken wraps to the airline Virgin Blue.^[24] Caramel apples have also been cited as a source of listerial infections which hospitalized 26 people, including five who died.^[25]^[26]

Prevention

Preventing listeriosis as a foodborne illness requires effective sanitation of food contact surfaces.^[27] Ethanol is an effective topical sanitizer against Listeria. Quaternary ammonium can be used in conjunction with alcohol as a food-contact safe sanitizer with increased duration of the sanitizing action.

Refrigerated foods in the home should be kept below 4°C (39°F) to discourage bacterial growth. Consumption of unpasteurized dairy products should be avoided.^[28] All raw meats (including beef, pork, poultry, and seafood) should be cooked to a safe internal temperature, typically 73°C (165°F) to properly kill the food-borne pathogen.^[29]

Treatment

In non-invasive listeriosis, the bacteria often remain within the digestive tract, causing mild symptoms lasting only a few days and requiring only supportive care. Muscle pain and fever in mild cases can be treated with over-the-counter pain relievers, and diarrhea and gastroenteritis can be treated with over-the-counter medications if needed.^[29]

In invasive listeriosis, the bacteria have spread to the bloodstream and central nervous system. Treatment includes intravenous delivery of high-dose antibiotics and in-patient hospital care.^[29] Duration of hospital care varies depending on how widespread the infection is, but is usually no less than 2 weeks.^[29] Ampicillin, penicillin, or amoxicillin are often given for invasive listeriosis, and gentamicin is often added in patients with compromised immune systems.^[30] Trimethoprim-sulfamethoxazole, vancomycin, and fluoroquinolones can be used in cases of allergy to penicillin.^[30] For treatment to be effective, the antibiotic must penetrate the host cell and bind to penicillin-binding protein 3 (PBP3). Cephalosporins are not effective for treatment of listeriosis.^[30]

Prompt treatment of listerial infections in pregnancy is critical to prevent the bacteria from infecting the fetus, and antibiotics may be given to pregnant women even in non-invasive listeriosis.^[31] Mirena Nikolova, et al., states that this is extremely crucial during the third trimester because the cell-mediated immunity is reduced during this time. Pfaff and Tillet say that listeriosis can have long-term consequences when contracted during pregnancy. This can included stillbirths, preterm labor, newborn sepsis, and meningitis. These oral therapies in less severe cases can include amoxicillin or erythromycin.^[30] In addition to antibiotics, infected pregnant women may be recommended to receive ultrasounds to monitor the health of the fetus. Higher doses of antibiotics are sometimes given to pregnant women to ensure penetration of the umbilical cord and placenta.^[32]

Asymptomatic patients who have been exposed to Listeria are not recommended for treatment. These patients should be informed of the signs and symptoms of the disease and to return for medical care if symptoms present.^[29]

Research

Some Listeria species are opportunistic pathogens: L. monocytogenes is most prevalent in the elderly, pregnant mothers, and patients infected with HIV. With improved healthcare leading to a growing elderly population and extended life expectancies for HIV infected patients, physicians are more likely to encounter this otherwise-rare infection (only seven per 1,000,000 healthy people are infected with virulent Listeria each year).^[13] Better understanding the cell biology of Listeria infections, including relevant virulence factors, may lead to better treatments for listeriosis and other intracytoplasmic parasite infections. Researchers are now investigating the use of Listeria as a cancer vaccine, taking advantage of its "ability to induce potent innate and adaptive immunity."^[18]^[33]

References

^ Jones, D. 1992. Current classification of the genus Listeria. In: Listeria 1992. Abstracts of ISOPOL XI, Copenhagen, Denmark). p. 7-8. ocourt, J., P. Boerlin, F.Grimont, C. Jacquet, and J-C. Piffaretti. 1992. Assignment of Listeria grayi and Listeria murrayi to a single species, Listeria grayi, with a revised description of Listeria grayi. Int. J. Syst. Bacteriol. 42:171-174.
^ Boerlin et al. 1992. L. ivanovii subsp. londoniensis subsp. novi. Int. J. Syst. Bacteriol. 42:69-73. Jones, D., and H.P.R. Seeliger. 1986. International committee on systematic bacteriology. Subcommittee the taxonomy of Listeria. Int. J. Syst. Bacteriol. 36:117-118.
^ "Five new Listeria species found; may improve tests | Cornell Chronicle". www.news.cornell.edu. Retrieved 15 May 2016.
^ Singleton P (1999). Bacteria in Biology, Biotechnology and Medicine (5th ed.). Wiley. pp. 444–454. ISBN 0-471-98880-4.
^ Christelle Guillet, Olivier Join-Lambert, Alban Le Monnier, Alexandre Leclercq, Frédéric Mechaï, Marie-France Mamzer-Bruneel, Magdalena K. Bielecka, Mariela Scortti, Olivier Disson, Patrick Berche, José Vazquez-Boland, Olivier Lortholary, and Marc Lecuit. Human Listeriosis Caused by Listeria ivanovii. Emerg Infect Dis. 2010 January; 16(1): 136–138.
^ "foodsafety.gov - Listeria".
^ Elliot T. Ryser, Elmer H. Marth. Listeria, Listeriosis, and Food Safety. Second edition. Elmer Marth. 1999.
^ Daniel Weller, Alexis Andrus, Martin Wiedmann and Henk C. den Bakker. Listeria booriae sp. nov. and Listeria newyorkensis sp. nov., from food processing environments in the USA. International Journal of Systematic and Evolutionary Microbiology (2015), 65, 286–292.
^ M. D. Collins, S. Wallbanks, D. J. Lane, J. Shah, R. Nietupskin, J. Smida, M. Dorsch and E. Stackebrandt. Phylogenetic Analysis of the Genus Listeria Based on Reverse Transcriptase Sequencing of 16S rRNA. International Journal of Systematic and Evolutionary Microbiology. April 1991 vol. 41 no. 2 240–246
^ "Listeria outbreak expected to cause more deaths across US in coming weeks". The Guardian. London. 29 September 2011.
^ Times, Los Angeles. "California plant issues massive apple recall due to listeria".
^ "Controlling Listeria Contamination in Your Meat Processing Plant". Government of Ontario. 27 February 2007. Retrieved 27 April 2010.
^ ^a ^b ^c ^d ^e ^f Southwick, F. S.; D. L. Purich. "More About Listeria". University of Florida Medical School. Retrieved 7 March 2007.
^ ^a ^b ^c ^d ^e ^f ^g ^h "Todar's Online Textbook of Bacteriology". Listeria monocytogenes and Listeriosis. Kenneth Todar University of Wisconsin-Madison Department of Biology. 2003. Retrieved 7 March 2007.
^ ^a ^b "Statistics about Salmonella food poisoning". WrongDiagnosis.com. 27 February 2007. Retrieved 7 March 2007.
^ Smith, G. A.; Portnoy D. A. (July 1997). "Trends in Microbiology". How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force. Cell Press. 5 (7, number 7): 272–276. doi:10.1016/S0966-842X(97)01048-2. PMID 9234509.
^ ^a ^b ^c Tinley, L. G.; et al. (1989). "Actin Filaments and the Growth, Movement, and Spread of the Intracellular Bacterial Parasite, Listeria monocytogenes". The Journal of Cell Biology. 109 (4 Pt 1): 1597–1608. doi:10.1083/jcb.109.4.1597. PMC 2115783. PMID 2507553.
^ ^a ^b "Listeria". MicrobeWiki.Kenyon.edu. 16 August 2006. Retrieved 7 March 2007.
^ ^a ^b Laine R. O.; Phaneuf K. L.; Cunningham C. C.; Kwiatkowski D.; Azuma T.; Southwick F. S. (1 August 1998). "Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells". Infect. Immun. 66 (8): 3775–82. PMC 108414. PMID 9673261.
^ Galbraith C. G.; Yamada K. M.; Galbraith J. A. (February 2007). "Polymerizing actin fibers position integrins primed to probe for adhesion sites". Science. 315 (5814): 992–5. doi:10.1126/science.1137904. PMID 17303755.
^ "Granny Smith, Gala apples recalled due to listeria". 16 January 2015.
^ Center for Science in the Public Interest – Nutrition Action Healthletter – Food Safety Guide – Meet the Bugs
^ William Neuman (27 September 2011). "Deaths From Cantaloupe Listeria Rise". The New York Times. Retrieved 13 November 2011.
^ Josephine Tovey (16 November 2011). "$236,000 fine for foul flight chicken". The Sydney Morning Herald. Retrieved 13 November 2011.
^ "Warning: Prepackaged Caramel Apples Linked To 5 Deaths".
^ "Listeria outbreak from caramel apples has killed four".
^ "Maple Leaf Foods assessing Listeria-killing chemical". ctv.ca. ctvglobemedia. The Canadian Press. 2008-10-12. Retrieved 15 October 2008.
^ "Food Safety - Listeria". Retrieved 11 May 2016.
^ ^a ^b ^c ^d ^e "CDC - Listeria - Home".
^ ^a ^b ^c ^d Temple, M. E.; Nahata, M. C. (May 2000). "Treatment of listeriosis". Annals of Pharmacotherapy. 34 (5): 656–61. doi:10.1345/aph.19315. PMID 10852095.
^ "Listeria infection (listeriosis): Treatments and drugs - MayoClinic.com".
^ Janakiraman V (2008). "Listeriosis in pregnancy: diagnosis, treatment, and prevention". Rev Obstet Gynecol. 1 (4): 179–85. PMC 2621056. PMID 19173022.
^ Greenemeier L (21 May 2008). "Recruiting a Dangerous Foe to Fight Cancer and HIV". Scientific American.

External links

Media related to Listeria at Wikimedia Commons

Listeriosis at DMOZ
Listeria genome at PATRIC, funded by the National Institute of Allergy and Infectious Diseases
Listeria at BacDive - the Bacterial Diversity Metadatabase

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. リステリア菌感染の臨床症状および診断 clinical manifestations and diagnosis of listeria monocytogenes infection
2. リステリア菌感染の治療、予後、および予防 treatment prognosis and prevention of listeria monocytogenes infection
3. 成人における特定病原体により引き起こされる細菌性髄膜炎の治療 treatment of bacterial meningitis caused by specific pathogens in adults
4. 成人における細菌性髄膜炎の初期治療および予後 initial therapy and prognosis of bacterial meningitis in adults
5. 成人における急性細菌性髄膜炎の臨床的特徴および診断 clinical features and diagnosis of acute bacterial meningitis in adults

English Journal

Inflammatory monocyte recruitment is regulated by IL-23 during systemic bacterial infection.

Indramohan M, Sieve AN, Break TJ, Berg RE.SourceDepartment of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.
Infection and immunity.Infect Immun.2012 Sep 10. [Epub ahead of print]
Listeria monocytogenes is a Gram-positive intracellular pathogen that causes meningitis and septicemia in immunocompromised individuals, and spontaneous abortion in pregnant women. The innate immune response against L. monocytogenes is primarily mediated by neutrophils and monocytes. IL-23 is an imp
PMID 22966045

Bilateral anterior uveitis in a patient with bacterial meningitis.

Otomo K, Kaburaki T, Shigeeda T, Takamoto M, Kawashima H, Araie M.SourceDepartment of Ophthalmology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. hhrpfb@yahoo.co.jp
International ophthalmology.Int Ophthalmol.2012 Aug;32(4):401-3. doi: 10.1007/s10792-012-9571-z. Epub 2012 May 26.
We report a case of bilateral iridocyclitis accompanied by bacterial meningitis in an immunocompetent patient. Case report. A 48 year-old healthy female visited our hospital with strong headache, fever, bilateral hyperemia, and blurred vision in both eyes. A slit-lamp examination revealed moderate c
PMID 22638923

Japanese Journal

リステリア髄膜炎の4例

羽田野ちひろ,深沢達也,加藤有一 [他]
日本小児科学会雑誌 = The journal of the Japan Pediatric Society 118(4), 661-664, 2014-04
NAID 40020067770

Rhombencephalitis Caused by Listeria monocytogenes

,
Internal Medicine 53(6), 639-640, 2014
NAID 130003392709

細菌性髄膜炎の遺伝子診断

生方公子
臨床神経学 53(11), 1184-1186, 2013
市中において発症する細菌性髄膜炎の主たる原因菌8種を同時に検索できる網羅的real-time PCR法の概略，ならびに髄液に対して培養法と本方法とを併行しておこなった結果について述べた．本方法は，もっとも適切な対応が求められる当該疾患の診断法として有用であり，その普及が望まれる．
NAID 130004505380

Related Pictures

★リンクテーブル★

リンク元	「リステリア髄膜炎」「Listeria monocytogenes meningitis」「Listeria meningoencephalitis」「Listeria髄膜炎」「リステリア菌性髄膜炎」

「リステリア髄膜炎」

Listeria
	Scanning electron micrograph of Listeria monocytogenes.
Scientific classification
Domain:	Bacteria
Division:	Firmicutes
Class:	Bacilli
Order:	Bacillales
Family:	Listeriaceae
Genus:	Listeria; Pirie 1940
Species
	L. aquatica; L. booriae; L. cornellensis; L. fleischmannii; L. floridensis; L. grandensis; L. grayi; L. innocua; L. ivanovii; L. marthii; L. monocytogenes; L. newyorkensis; L. riparia; L. rocourtiae; L. seeligeri; L. weihenstephanensis; L. welshimeri

　　[★]

英: Listeria meningitis
関: リステリア・モノサイトゲネス髄膜炎、Listeria髄膜炎、リステリア菌性髄膜炎、リステリア髄膜脳炎

「Listeria monocytogenes meningitis」

　　[★]

リステリア・モノサイトゲネス髄膜炎、Listeria monocytogenes髄膜炎

関: Listeria meningitis、Listeria meningoencephalitis

「Listeria meningoencephalitis」

　　[★]

リステリア髄膜脳炎

関: Listeria meningitis、Listeria monocytogenes meningitis

「Listeria髄膜炎」

　　[★]

英: Listeria meningitis
関: リステリア髄膜炎、リステリア菌性髄膜炎

「リステリア菌性髄膜炎」

　　[★]

英: Listeria meningitis
関: リステリア髄膜炎、Listeria髄膜炎

[1] Jones, D. 1992. Current classification of the genus Listeria. In: Listeria 1992. Abstracts of ISOPOL XI, Copenhagen, Denmark). p. 7-8. ocourt, J., P. Boerlin, F.Grimont, C. Jacquet, and J-C. Piffaretti. 1992. Assignment of Listeria grayi and Listeria murrayi to a single species, Listeria grayi, with a revised description of Listeria grayi. Int. J. Syst. Bacteriol. 42:171-174.

[2] Boerlin et al. 1992. L. ivanovii subsp. londoniensis subsp. novi. Int. J. Syst. Bacteriol. 42:69-73. Jones, D., and H.P.R. Seeliger. 1986. International committee on systematic bacteriology. Subcommittee the taxonomy of Listeria. Int. J. Syst. Bacteriol. 36:117-118.

[Cornell-3] "Five new Listeria species found; may improve tests | Cornell Chronicle". www.news.cornell.edu. Retrieved 15 May 2016.

[Singleton-4] Singleton P (1999). Bacteria in Biology, Biotechnology and Medicine (5th ed.). Wiley. pp. 444–454. ISBN 0-471-98880-4.

[5] Christelle Guillet, Olivier Join-Lambert, Alban Le Monnier, Alexandre Leclercq, Frédéric Mechaï, Marie-France Mamzer-Bruneel, Magdalena K. Bielecka, Mariela Scortti, Olivier Disson, Patrick Berche, José Vazquez-Boland, Olivier Lortholary, and Marc Lecuit. Human Listeriosis Caused by Listeria ivanovii. Emerg Infect Dis. 2010 January; 16(1): 136–138.

[foodsafety-6] "foodsafety.gov - Listeria".

[7] Elliot T. Ryser, Elmer H. Marth. Listeria, Listeriosis, and Food Safety. Second edition. Elmer Marth. 1999.

[8] Daniel Weller, Alexis Andrus, Martin Wiedmann and Henk C. den Bakker. Listeria booriae sp. nov. and Listeria newyorkensis sp. nov., from food processing environments in the USA. International Journal of Systematic and Evolutionary Microbiology (2015), 65, 286–292.

[collins-9] M. D. Collins, S. Wallbanks, D. J. Lane, J. Shah, R. Nietupskin, J. Smida, M. Dorsch and E. Stackebrandt. Phylogenetic Analysis of the Genus Listeria Based on Reverse Transcriptase Sequencing of 16S rRNA. International Journal of Systematic and Evolutionary Microbiology. April 1991 vol. 41 no. 2 240–246

[10] "Listeria outbreak expected to cause more deaths across US in coming weeks". The Guardian. London. 29 September 2011.

[11] Times, Los Angeles. "California plant issues massive apple recall due to listeria".

[rts4A-12] "Controlling Listeria Contamination in Your Meat Processing Plant". Government of Ontario. 27 February 2007. Retrieved 27 April 2010.

[rts1-13] ^ ^a ^b ^c ^d ^e ^f Southwick, F. S.; D. L. Purich. "More About Listeria". University of Florida Medical School. Retrieved 7 March 2007.

[rts2-14] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Todar's Online Textbook of Bacteriology". Listeria monocytogenes and Listeriosis. Kenneth Todar University of Wisconsin-Madison Department of Biology. 2003. Retrieved 7 March 2007.

[rts3-15] "Statistics about Salmonella food poisoning". WrongDiagnosis.com. 27 February 2007. Retrieved 7 March 2007.

[rts5-16] Smith, G. A.; Portnoy D. A. (July 1997). "Trends in Microbiology". How the Listeria monocytogenes ActA protein converts actin polymerization into a motile force. Cell Press. 5 (7, number 7): 272–276. doi:10.1016/S0966-842X(97)01048-2. PMID 9234509.

[Tinley89-17] Tinley, L. G.; et al. (1989). "Actin Filaments and the Growth, Movement, and Spread of the Intracellular Bacterial Parasite, Listeria monocytogenes". The Journal of Cell Biology. 109 (4 Pt 1): 1597–1608. doi:10.1083/jcb.109.4.1597. PMC 2115783. PMID 2507553.

[rts4-18] "Listeria". MicrobeWiki.Kenyon.edu. 16 August 2006. Retrieved 7 March 2007.

[Laine98-19] Laine R. O.; Phaneuf K. L.; Cunningham C. C.; Kwiatkowski D.; Azuma T.; Southwick F. S. (1 August 1998). "Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells". Infect. Immun. 66 (8): 3775–82. PMC 108414. PMID 9673261.

[20] Galbraith C. G.; Yamada K. M.; Galbraith J. A. (February 2007). "Polymerizing actin fibers position integrins primed to probe for adhesion sites". Science. 315 (5814): 992–5. doi:10.1126/science.1137904. PMID 17303755.

[21] "Granny Smith, Gala apples recalled due to listeria". 16 January 2015.

[22] Center for Science in the Public Interest – Nutrition Action Healthletter – Food Safety Guide – Meet the Bugs

[23] William Neuman (27 September 2011). "Deaths From Cantaloupe Listeria Rise". The New York Times. Retrieved 13 November 2011.

[24] Josephine Tovey (16 November 2011). "$236,000 fine for foul flight chicken". The Sydney Morning Herald. Retrieved 13 November 2011.

[25] "Warning: Prepackaged Caramel Apples Linked To 5 Deaths".

[26] "Listeria outbreak from caramel apples has killed four".

[27] "Maple Leaf Foods assessing Listeria-killing chemical". ctv.ca. ctvglobemedia. The Canadian Press. 2008-10-12. Retrieved 15 October 2008.

[28] "Food Safety - Listeria". Retrieved 11 May 2016.

[cdc-29] "CDC - Listeria - Home".

[temple-30] Temple, M. E.; Nahata, M. C. (May 2000). "Treatment of listeriosis". Annals of Pharmacotherapy. 34 (5): 656–61. doi:10.1345/aph.19315. PMID 10852095.

[31] "Listeria infection (listeriosis): Treatments and drugs - MayoClinic.com".

[32] Janakiraman V (2008). "Listeriosis in pregnancy: diagnosis, treatment, and prevention". Rev Obstet Gynecol. 1 (4): 179–85. PMC 2621056. PMID 19173022.

[33] Greenemeier L (21 May 2008). "Recruiting a Dangerous Foe to Fight Cancer and HIV". Scientific American.

v t e Food safety

Adulterants, food contaminants	3-MCPD Aldicarb Cyanide Formaldehyde Lead poisoning Melamine Mercury in fish Sudan I

Flavorings	Monosodium glutamate (MSG) Salt Sugar High-fructose corn syrup

Microorganisms	Botulism Campylobacter jejuni Clostridium perfringens Escherichia coli O104:H4 Escherichia coli O157:H7 Hepatitis A Hepatitis E Listeria Norovirus Rotavirus Salmonella

Parasitic infections through food	Anisakiasis Amoebiasis/Amoebic dysentery Cryptosporidiosis Cyclosporiasis Diphyllobothriasis Enterobiasis Fascioliasis Fasciolopsiasis Giardiasis Gnathostomiasis Paragonimiasis Toxoplasmosis Trichinosis Trichuriasis

Pesticides	Chlorpyrifos DDT Lindane Malathion Methamidophos

Preservatives	Benzoic acid Ethylenediaminetetraacetic acid (EDTA) Sodium benzoate

Sugar substitutes	Acesulfame potassium Aspartame Saccharin Sodium cyclamate Sorbitol Sucralose

Toxins, poisons, environment pollution	Aflatoxin Arsenic contamination of groundwater Benzene in soft drinks Bisphenol A Mycotoxins Shellfish poisoning dioxin Dieldrin Nonylphenol Diethylstilbestrol

Food contamination incidents	Devon colic 1858 Bradford sweets poisoning 1989 Chilean grape scare 1993 Jack in the Box E. coli outbreak 1996 Odwalla E. coli outbreak 1999 Sun Orchard salmonellosis outbreak 2005 Indonesia food scare 2006 North American E. coli O157:H7 outbreaks 2007 Vietnam food scare 2008 Canada listeriosis outbreak 2008 Chinese milk scandal 2008 Irish pork crisis 2008 United States salmonellosis outbreak 2011 Germany E. coli O104:H4 outbreak 2011 Taiwan food scandal 2011 United States listeriosis outbreak Food safety incidents in China Foodborne illness outbreaks death toll United States ICA meat repackaging controversy Minamata disease StarLink corn recall Toxic oil syndrome 2013 meat adulteration scandal 2013 aflatoxin contamination 2013 Taiwan food scandal 2014 Taiwan food scandal 2015 United States E. coli outbreak 2017 Brazil weak meat scandal

Regulation, standards, watchdogs	Acceptable daily intake E number Food labeling regulations Food libel laws International Food Safety Network ISO 22000 Quality Assurance International

Institutions	International Food Safety Network List of food safety organisations Institute for Food Safety and Health Ministry of Food and Drug Safety Centre for Food Safety European Food Safety Authority

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Listeria meningitis