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flagellate protozoan that causes leishmaniasis (同)genus Leishmania

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/28 08:32:41」(JST)

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Leishmania infantum is the causative agent of infantile visceral leishmaniasis in the Mediterranean region of the Old World and in Latin America, where it has been called Leishmania chagasi.^[1]^[2] It is also an unusual cause of cutaneous leishmaniasis,^[3] which is normally caused by specific lineages (or zymodemes). Wild canids and domestic dogs are the natural reservoir of this organism. Leishmania infantum is closely related to Leishmania donovani, and some authors believe that these two species are so close as to actually be subspecies of each other; ^[4] however, phylogenetic analyses can easily distinguish between the two groups, although analysis has shown that some isolates of Leishmania donovani have been classified as Leishmania infantum and that the former includes a number of different genetic groups.^[5]

References[edit]

^ Lukeš J. et al. (2007). "Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy". Proceedings of the National Academy of Sciences 104 (22): 9375–80. doi:10.1073/pnas.0703678104. PMC 1890502. PMID 17517634.
^ Maurício IL, Stothard JR, Miles MA (May 2000). "The strange case of Leishmania chagasi". Parasitol. Today (Regul. Ed.) 16 (5): 188–9. doi:10.1016/S0169-4758(00)01637-9. PMID 10782075.
^ BenSaid M, Guerbouj S, Saghrouni F, et al. (2006). "Occurrence of Leishmania infantum cutaneous leishmaniasis in central Tunisia". Transactions of the Royal Society of Tropical Medicine and Hygiene 100 (6): 521–26. doi:10.1016/j.trstmh.2005.08.012. PMID 16356518.
^ Le Blancq SM, Peters W (1986). "Leishmania in the Old World: 4. The distribution of L. donovani sensu lato zymodemes". Trans. R. Soc. Trop. Med. Hyg. 80 (3): 367–77. doi:10.1016/0035-9203(86)90320-2. PMID 3798531.
^ Kuhls K, Mauricio IL, Pratlong F, Presber W, Schönian G (2005). "Analysis of ribosomal DNA internal transcribed spacer sequences of the Leishmania donovani complex". Microbes Infect. 7 (11-12): 1224–34. doi:10.1016/j.micinf.2005.04.009. PMID 16002315.

External links[edit]

Dantas-Torres F. (2008). "Canine vector-borne diseases in Brazil". Parasites & Vectors 1: 25. doi:10.1186/1756-3305-1-25. figure 3 and figure 5.
Leishmania infantum at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. 内臓リーシュマニア症の臨床症状および診断 clinical manifestations and diagnosis of visceral leishmaniasis
2. 内臓リーシュマニア症の治療 treatment of visceral leishmaniasis
3. 内臓リーシュマニア症の疫学および管理 epidemiology and control of visceral leishmaniasis
4. 中央アフリカへの旅行によって感染する可能性のある疾患 diseases potentially acquired by travel to central africa
5. 脾腫およびその他の脾疾患を有する成人患者に対するアプローチ approach to the adult patient with splenomegaly and other splenic disorders

English Journal

Does Leishmaniasis disease alter the parenchyma and protein expression in salivary glands?

Júnior AM1, de Amorim Carvalho FA2, de Oliveira Dantas W3, Gomes LC3, da Silva AB3, de Sousa Cavalcante MM3, de Oliveira IM3, de Deus Moura de Lima M4, Rizzo Mdos S5, de Carvalho Leite CM3, Moura SM3, de Deus Moura Lde F4, da Silva BB6.
Experimental biology and medicine (Maywood, N.J.).Exp Biol Med (Maywood).2016 Feb;241(4):359-66. doi: 10.1177/1535370215614658. Epub 2015 Nov 13.
Leishmaniasis is considered a serious public health problem in several regions in Brazil and worldwide. This research aimed to perform a histopathological and proteomic study of parotid, submandibular and sublingual glands of BALB/c mice infected by Leishmania (L) infantum chagasi using histological
PMID 26568331

Intranasal vaccination with killed Leishmania amazonensis promastigotes antigen (LaAg) associated with CAF01 adjuvant induces partial protection in BALB/c mice challenged with Leishmania (infantum) chagasi - CORRIGENDUM.

Leal JM, Mosquini M, Covre LP, Stagmiller NP, Rodrigues RR, Christensen D, Guedes HL, Rossi-Bergmann B, Gomes DC.
Parasitology.Parasitology.2016 Jan;143(1):123. Epub 2015 Nov 2.
PMID 26521984

The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi.

Pereira WL1, de Souza Vasconcellos R2,3, Mariotini-Moura C4,5, Saar Gomes R6, Firmino Rde C7,8, da Silva AM9, Silva Júnior A10, Bressan GC11, Almeida MR12, Crocco Afonso LC13, Teixeira RR14, Lopes Rangel Fietto J15,16.
Molecules (Basel, Switzerland).Molecules.2015 Dec 14;20(12):22435-44. doi: 10.3390/molecules201219857.
Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of these diseases relies on multiple parenteral inje
PMID 26703536

Japanese Journal

Involvement of CD4+ Foxp3+ Regulatory T Cells in Persistence of Leishmania donovani in the Liver of Alymphoplastic aly/aly Mice

Tiwananthagorn Saruda,Iwabuchi Kazuya,Ato Manabu,Sakurai Tatsuya,Kato Hirotomo,Katakura Ken
PLoS Neglected Tropical Diseases 6(8), e1798, 2012-08-21
… Visceral leishmaniasis (VL) is a chronic and fatal disease in humans and dogs caused by the intracellular protozoan parasites, Leishmania donovani and L. … chagasi). …
NAID 120004756399

In Vitro Antiproliferative Effects of Several Diaryl Derivatives on Leishmania spp

ALVES Luciana Vignolio,DO CANTO-CAVALHEIRO Marilene Marcuzzo,CYSNE-FINKELSTEIN Lea,LEON Leonor
Biological & pharmaceutical bulletin 26(4), 453-456, 2003-04-01
… These drugs were assayed against Leishmania amazonensis, L. … chagasi promastigotes containing a high percentage of metacyclic forms and the axenic amastigote form of L. …
NAID 110003608453

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★リンクテーブル★

リンク元	「シャーガスリーシュマニア」「リーシュマニア・シャガシ」
関連記事	「Leishmania」

「シャーガスリーシュマニア」

Leishmania infantum
Scientific classification
Domain:	Eukaryota
(unranked):	Excavata
Phylum:	Euglenozoa
Class:	Kinetoplastida
Order:	Trypanosomatida
Family:	Trypanosomatidae
Genus:	Leishmania
Species:	L. infantum
Binomial name
	Leishmania infantum; Nicolle, 1908