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a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/09 20:05:54」(JST)

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Lassa virus (LASV) is an arenavirus that causes Lassa hemorrhagic fever,^[1] a type of viral hemorrhagic fever (VHF), in human and non-human primates. Lassa virus is an emerging virus and a select agent, requiring Biosafety Level 4-equivalent containment. It is endemic in West African countries, especially Sierra Leone, the Republic of Guinea, Nigeria, and Liberia, where the annual incidence of infection is between 300,000 and 500,000 cases, resulting in 5,000 deaths per year.^[2]

Recent discoveries within the Mano River region of west Africa have expanded the endemic zone between the two known Lassa endemic regions, indicating that LASV is more widely distributed throughout the tropical wooded savannah ecozone in west Africa.^[3] Currently, there are no approved vaccines against Lassa fever for use in humans.^[4]

Virology

Structure and genome

Lassa viruses^[5] are enveloped, single-stranded, bisegmented, ambisense RNA viruses. Their genome^[6] is contained in two RNA segments that code for two proteins each, one in each sense, for a total of four viral proteins.^[7] The large segment encodes a small zinc-binding protein (Z) that regulates transcription and replication,^[8]^[9] and the RNA polymerase (L). The small segment encodes the nucleoprotein (NP) and the surface glycoprotein precursor (GP, also known as the viral spike), which is proteolytically cleaved into the envelope glycoproteins GP1 and GP2 that bind to the alpha-dystroglycan receptor and mediate host cell entry.^[10]

Lassa fever causes hemorrhagic fever frequently shown by immunosuppression. Replication for Lassa virus is very rapid, while also demonstrating temporal control in replication.^[11] The first replication step is transcription of mRNA copies of the negative- or minus-sense genome. This ensures an adequate supply of viral proteins for subsequent steps of replication, as the NP and L proteins are translated from the mRNA. The positive- or plus-sense genome, then makes viral complementary RNA (vcRNA) copies of itself. The RNA copies are a template for producing negative-sense progeny, but mRNA is also synthesized from it. The mRNA synthesized from vcRNA are translated to make the GP and Z proteins. This temporal control allows the spike proteins to be produced last, and therefore, delay recognition by the host immune system.

Nucleotide studies of the genome have shown that Lassa has four lineages: three found in Nigeria and the fourth in Guinea, Liberia, and Sierra Leone. The Nigerian strains seem likely to have been ancestral to the others but additional work is required to confirm this.^[12] One book that explains about this disease is The Lassa Ward by Ross I. Donaldson. He describes what it is like being a doctor and taking care of the Sierra Leone people who have contracted the virus.

Receptors

The Lassa virus gains entry into the host cell by means of the cell-surface receptor the alpha-dystroglycan (alpha-DG),^[10] a versatile receptor for proteins of the extracellular matrix. It shares this receptor with the prototypic Old World arenavirus lymphocytic choriomeningitis virus. Receptor recognition depends on a specific sugar modification of alpha-dystroglycan by a group of glycosyltransferases known as the LARGE proteins. Specific variants of the genes encoding these proteins appear to be under positive selection in West Africa where Lassa is endemic. Alpha-dystroglycan is also used as a receptor by viruses of the New World clade C arenaviruses (Oliveros and Latino viruses). In contrast, the New World arenaviruses of clades A and B, which include the important viruses Machupo, Guanarito, Junin, and Sabia in addition to the non pathogenic Amapari virus, use the transferrin receptor 1. A small aliphatic amino acid at the GP1 glycoprotein amino acid position 260 is required for high-affinity binding to alpha-DG. In addition, GP1 amino acid position 259 also appears to be important, since all arenaviruses showing high-affinity alpha-DG binding possess a bulky aromatic amino acid (tyrosine or phenylalanine) at this position.

Unlike most enveloped viruses which use clathrin coated pits for cellular entry and bind to their receptors in a pH dependent fashion, Lassa and lymphocytic choriomeningitis virus instead use an endocytotic pathway independent of clathrin, caveolin, dynamin and actin. Once within the cell the viruses are rapidly delivered to endosomes via vesicular trafficking albeit one that is largely independent of the small GTPases Rab5 and Rab7. On contact with the endosome pH-dependent membrane fusion occurs mediated by the envelope glycoprotein, which at the lower pH of the endosome binds the lysosome protein LAMP1 which results in membrane fusion and escape from the endosome.

Life cycle

The life cycle of Lassa virus is similar to the Old World arenaviruses. Lassa virus enters the cell by the receptor-mediated endocytosis. Which endocytotic pathway is used is not known yet, but at least the cellular entry is sensitive to cholesterol depletion. It was reported that virus internalization is limited upon cholesterol depletion. The receptor used for cell entry is alpha-dystroglycan, a highly conserved and ubiquitously expressed cell surface receptor for extracellular matrix proteins. Dystroglycan, which is later cleaved into alpha-dystroglycan and beta-dystroglycan is originally expressed in most cells to mature tissues, and it provides molecular link between the ECM and the actin-based cytoskeleton.^[13] After virus enters the cell by alpha-dystroglycan mediated endocytosis, low-pH environment triggers pH-dependent membrane fusion and releases RNP (viral ribonucleoprotein) complex into the cytoplasm. Viral RNA is unpacked, and replication and transcription initiate in the cytoplasm.^[13] As the replication starts, both S and L RNA genomes synthesize the antigenomic S and L RNAs, and from the antigenomic RNAs, genomic S and L RNA are synthesized. Both genomic and antigenomic RNAs are needed for transcription and translation. S RNA encodes GP and NP (viral nucleocapsid protein) proteins, and L RNA encodes Z and L proteins. L protein most likely represents the viral RNA-dependent RNA polymerase.^[14] When the cell is infected by the virus, L polymerase is associated with the viral RNP and initiates the transcription of the genomic RNA. The 5’ and 3’ terminal 19 nt viral promoter regions of both RNA segments are necessary for recognition and binding of the viral polymerase. The primary transcription first transcribes mRNAs from the genomic S and L RNAs, which code NP and L proteins, respectively. Transcription terminates at the stem-loop (SL) structure within the intergenomic region. Arenaviruses use a cap snatching strategy to gain the cap structures from the cellular mRNAs, and it is mediated by the endonuclease activity of the L polymerase and the cap binding activity of NP. Antigenomic RNA transcribes viral genes GPC and Z, encoded in genomic orientation, from S and L segments respectively. The antigenomic RNA also serves as the template for the replication.^[15] After translation of GPC, it is posttranslationally modified in the endoplasmic reticulum. GPC is cleaved into GP1 and GP2 at the later stage of the secretory pathway. It is reported the cellular protease SKI-1/S1P was responsible for the cleavage. Cleaved glycoproteins are incorporated into the virion envelope when the virus buds and release from the cell membrane.^[14]

Pathogenesis

The well-known Lassa fever is mostly caused by the Lassa virus. The symptoms include flu-like illness characterized by fever, general weakness, cough, sore throat, headache, and gastrointestinal manifestations. Hemorrhagic manifestations are other features of Lassa fever, which include vascular permeability.^[15]

The pathogenesis of the Lassa virus remains unclear, but it has been shown that the main targets of the virus are antigen-presenting cells (mainly dendritic cells) and endothelial cells.^[16]^[17]^[18] Also, it is reported that Lassa virus prevents a host’s innate immune system by NP activity. Generally, when a pathogen enters into a host, innate defense system recognizes the PAMPs (Pathogen-associated molecular patterns) and activates immune responses. One of the mechanisms detects double stranded RNA which is only synthesized by negative-sense viruses. In the cytoplasm, dsRNA receptors, such as RIG-I (retinoic acid-inducible gene I) and MDA-5 (melanoma differentiation associated gene 5), detects double stranded RNAs and initiates signaling pathways that results in translocation of IRF-3 (interferon regulatory factor 3) and other transcription factors to the nucleus. Translocated transcription factors activate expression of interferons 𝛂and 𝛃, and secreted interferons initiate antiviral responses including adaptive immunity. NP encoded in Lassa virus is essential in viral replication and transcription, but it also suppresses host innate IFN response by inhibiting translocation of IRF-3. NP of Lassa virus is reported to have an exonuclease activity to only dsRNAs. dsRNA exonuclease activity of the NP leads to counteract IFN responses by digesting the PAMP which leads to the evasion of host immune responses.^[19]

Upon entry, the Lassa virus infects almost every tissue in the human body. It starts with the mucosa, intestine, lungs and urinary system, and then progresses to the vascular system.^[20]

Currently there is no US licensed vaccine for humans against the Lassa virus. Evaluation of Lassa virus vaccine immunogenicity in the CBA/J-ML29 mouse model is ongoing. A single intraperitoneal immunization of CBA/J mice with ML29 protected animals against a lethal homologous intracerebral challenge with 588 LD. Lassa fever is one of the most prevalent viral hemorrhagic fevers in West Africa responsible for thousands of deaths annually.

References

^ Frame JD, Baldwin JM, Gocke DJ, Troup JM (1 July 1970). "Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings". Am. J. Trop. Med. Hyg. 19 (4): 670–6. PMID 4246571.
^ "Lassa Fever Fact Sheet".
^ Sogoba, N.; Feldmann, H.; Safronetz, D. (14 November 2012). "Lassa Fever in West Africa: Evidence for an Expanded Region of Endemicity". Zoonoses & Public Health 59 (59): 43–47. doi:10.1111/j.1863-2378.2012.01469.x.
^ Yun, N; Walker, D (4 October 2012). "Pathogenesis of Lassa Fever". Viruses 4: 2031–2048. doi:10.3390/v4102031. PMC 3497040. PMID 23202452.
^ Lashley, Felissa R., and Jerry D. Durham. Emerging Infectious Diseases: Trends and Issues. New York: Springer Pub., 2002. Print.
^ Ridley, Matt. Genome: The Autobiography of a Species in 23 Chapters. New York: HarperCollins, 1999. Print.
^ "Lassa virus RefSeq Genome".
^ Cornu, T. I.; De La Torre, J. C. (2001). "RING Finger Z Protein of Lymphocytic Choriomeningitis Virus (LCMV) Inhibits Transcription and RNA Replication of an LCMV S-Segment Minigenome". Journal of Virology 75 (19): 9415–9426. doi:10.1128/JVI.75.19.9415-9426.2001. PMC 114509. PMID 11533204.
^ Djavani M, et al. (Sep 1997). "Completion of the Lassa fever virus sequence and identification of a RING finger open reading frame at the L RNA 5' End.". Virology 235 (2): 414–8. doi:10.1006/viro.1997.8722.
^ ^a ^b Cao, W.; Henry, M. D.; Borrow, P.; Yamada, H.; Elder, J. H.; Ravkov, E. V.; Nichol, S. T.; Compans, R. W.; Campbell, K. P.; Oldstone, M. B. (1998). "Identification of -Dystroglycan as a Receptor for Lymphocytic Choriomeningitis Virus and Lassa Fever Virus". Science 282 (5396): 2079–2081. doi:10.1126/science.282.5396.2079. PMID 9851928.
^ Lashley, Felissa (2002). Emerging Infectious Diseases Trends and Issues. Springer Publishing Company.
^ Bowen MD, Rollin PE, Ksiazek TG, et al. (August 2000). "Genetic Diversity among Lassa Virus Strains". J. Virol. 74 (15): 6992–7004. doi:10.1128/JVI.74.15.6992-7004.2000. PMC 112216. PMID 10888638.
^ ^a ^b Rojek JM, Kunz S (April 2008). "Cell Entry by Human Pathogenic Arenaviruses". Cell Microbiol. 10 (4): 828–35. doi:10.1111/j.1462-5822.2007.01113.x. PMID 18182084.
^ ^a ^b Drosten C, Kümmerer BM, Schmitz H, Günther S (January 2003). "Molecular Diagnostics of Viral Hemorrhagic Fevers". Antivural Res. 57 (1-2): 61–87. doi:10.1016/s0166-3542(02)00201-2. PMID 12615304.
^ ^a ^b Yun NE, Walker DH (October 2012). "Pathogenesis of Lassa Fever". Viuses. 4 (10): 2031–48. doi:10.3390/v4102031. PMC 3497040. PMID 23202452.
^ Levene, M. I.; Gibson, N. A.; Fenton, A. C.; Papathoma, E.; Barnett, D. (1990). "The use of a calcium-channel blocker, nicardipine, for severely asphyxiated newborn infants". Developmental medicine and child neurology 32 (7): 567–574. PMID 2391009.
^ Mahanty, S.; Hutchinson, K.; Agarwal, S.; McRae, M.; Rollin, P. E.; Pulendran, B. (2003). "Cutting edge: Impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses". Journal of immunology (Baltimore, Md. : 1950) 170 (6): 2797–2801. doi:10.4049/jimmunol.170.6.2797. PMID 12626527.
^ Baize, S.; Kaplon, J.; Faure, C.; Pannetier, D.; Georges-Courbot, M. C.; Deubel, V. (2004). "Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells". Journal of immunology (Baltimore, Md. : 1950) 172 (5): 2861–2869. doi:10.4049/jimmunol.172.5.2861. PMID 14978087.
^ Hastie KM, Bale S, Kimberlin CR, Saphire EO (April 2012). "Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses". Current Opinion in Virology 2 (2): 151–6. doi:10.1016/j.coviro.2012.01.003. PMID 22482712.
^ Donaldson, Ross I. (2009). The Lassa Ward:One Man's Fight Against One of the World's Deadliest Diseases. St. Martin's Press. ISBN 0-312-37700-2. ISBN 978-0-312-37700-7.

Sunday, Omilabu. "Hospital-Based Surveillance For Lassa Fever In Edo State, Nigeria, 2005-2008". Tropical Medicine & International Health.
Echioya, Deborah U.; Hass, Meike; Olshlager, Stephan; Becker-Ziaja, Beate; Chukwu, Christian O. Onyebuchi; Coker, Jide; Nasidi, Abdulsalam; Ogugua, Osi-Ogdu; Gunther, Stephan; Omilabu, Sunday A. (2010). "Lassa Fever, Nigeria, 2005-2008". Emerging Infectious Diseases. 6 16: 1040–41. doi:10.3201/eid1606.100080.
Branco, Luis M.; Grove, Jessica N.; Boisen, Matt L.; Shaffer, Jeffrey G.; Goba, Augustine; Fullah, Mohammed; Momoh, Mambu; Grant, Donald S.; Garry, Robert F. (October 4, 2011). "Emerging Trends in Lassa Fever: Redefining the Role of Immunoglobulin M and Inflammation in Diagnosing Acute Infection". Virology Journal 8: 478–462. doi:10.1186/1743-422x-8-478.
Hastie, Kathryn M.; King, Liam B.; Zandonatti, Michelle A.; Saphire, Erica Ollmann; Menéndez-Arias, Luis (Aug 2012). "Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease.". PLoS ONE 7 (8): p1–8. doi:10.1371/journal.pone.0044211. CS1 maint: Extra text (link)
Joseph B. McCormick, Isabel J. King, Patricia A. Webb, Karl M. Johnson, Renie O'Sullivan, Ethleen S. Smith, Sally Trippel and Tony C. Tong
The Journal of Infectious Diseases, Vol. 155, No. 3 (Mar., 1987), pp. 445–455
Salami, Rilwan (2012-02-27). "22 Die of Lassa Fever in Edo". The Nation. Retrieved 2012-11-16.

UpToDate Contents

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1. サハラ以南アフリカへの旅行によって感染する可能性のある疾患 diseases potentially acquired by travel to sub saharan africa
2. エボラ出血熱およびマールブルグ出血熱の疫学、病因、および臨床症状 epidemiology pathogenesis and clinical manifestations of ebola and marburg hemorrhagic fever
3. 血小板減少症を有する成人患者に対するアプローチ approach to the adult patient with thrombocytopenia
4. 成人における不明熱に対するアプローチ approach to the adult with fever of unknown origin
5. 慢性C型肝炎ウイルス感染の診断および評価 diagnosis and evaluation of chronic hepatitis c virus infection

English Journal

Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus.

Burgeson JR, Gharaibeh DN, Moore AL, Larson RA, Amberg SM, Bolken TC, Hruby DE, Dai D.SourceSIGA Technologies, Inc., 4575 SW Research Way, Suite 230, Corvallis, OR 97333, United States.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2013 Nov 1;23(21):5840-3. doi: 10.1016/j.bmcl.2013.08.103. Epub 2013 Sep 5.
Previously we reported the optimization of antiviral scaffolds containing benzimidazole and related heterocycles possessing activity against a variety of arenaviruses. These series of compounds were discovered through an HTS campaign of a 400,000 small molecule library using lentivirus-based pseudot
PMID 24064500

Role of DC-SIGN in Lassa Virus Entry into Human Dendritic Cells.

Goncalves AR, Moraz ML, Pasquato A, Helenius A, Lozach PY, Kunz S.SourceInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Journal of virology.J Virol.2013 Nov;87(21):11504-15. doi: 10.1128/JVI.01893-13. Epub 2013 Aug 21.
The arenavirus Lassa virus (LASV) causes a severe hemorrhagic fever with high mortality in humans. Antigen-presenting cells, in particular dendritic cells (DCs), are early and preferred targets of LASV, and their productive infection contributes to the virus-induced immunosuppression observed in fat
PMID 23966408

Crystal structure of Junin virus nucleoprotein.

Zhang Y, Li L, Liu X, Dong S, Wang W, Huo T, Guo Y, Rao Z, Yang C.SourceState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, PR China.
The Journal of general virology.J Gen Virol.2013 Oct;94(Pt 10):2175-83. doi: 10.1099/vir.0.055053-0. Epub 2013 Jul 24.
Junin virus (JUNV) has been identified as the aetiological agent of Argentine haemorrhagic fever (AHF), which is a serious public health problem with approximately 5 million people at risk. It is treated as a potential bioterrorism agent because of its rapid transmission by aerosols. JUNV is a negat
PMID 23884367

Japanese Journal

The PI3K/Akt Pathway Contributes to Arenavirus Budding

Urata Shuzo,Ngo Nhi,de la Torre Juan Carlos
Journal of Virology 86(8), 4578-4585, 2012-04
… Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF) disease in humans and pose a significant public health concern in regions where they are endemic. … On the other hand, evidence indicates that the globally distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen. …
NAID 120005121745

アレナウイルス感染症

谷英樹,福士秀悦,吉河智城,西條政幸,森川茂
ウイルス 62(2), 229-238, 2012
　アレナウイルスはアレナウイルス科に属するウイルスの総称で，細胞内で増殖し，ウイルス粒子内に宿主細胞のリボゾームが取り込まれ，これが砂状に見えるのでラテン語の砂粒(arenosus) にちなんで命名された．感染症法において1類感染症に指定されているラッサ熱を引き起こすラッサウイルス，南米出血熱の原因ウイルスとしてフニンウイルス，グアナリトウイルス，サビアウイルス，マチュポウイルス，チャパレウイルス …
NAID 130004470991

Cell Surface Molecules Involved in Infection Mediated by Lymphocytic Choriomeningitis Virus Glycoprotein

SHIMOJIMA Masayuki,KAWAOKA Yoshihiro
Journal of Veterinary Medical Science 74(10), 1363-1366, 2012
… The glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), the prototype arenavirus, is a promising envelope protein of lentiviral pseudotype vectors for gene therapy. … Here, we examined whether infection of LCMV-GP-pseudotypes was affected by the expression of four cell surface molecules-Axl and Tyro3 (from the TAM family) and DC-SIGN and LSECtin (from the C-type lectin family)-that are known receptors of Lassa virus, another arenavirus. …
NAID 130001879836

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リンク元	「Lassaウイルス」「ラッサ熱ウイルス」
関連記事	「virus」

「Lassaウイルス」

Lassa Virus (LASV)
	TEM micrograph of Lassa virus virions.
Virus classification
Group:	Group V ((-)ssRNA)
Order:	Unassigned
Family:	Arenaviridae
Genus:	Arenavirus
Species:	Lassa virus

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英: Lassa virus
関: ラッサ熱ウイルス

「ラッサ熱ウイルス」

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英: Lassa virus
関: Lassaウイルス

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[Frame_1970-1] Frame JD, Baldwin JM, Gocke DJ, Troup JM (1 July 1970). "Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings". Am. J. Trop. Med. Hyg. 19 (4): 670–6. PMID 4246571.

[2] "Lassa Fever Fact Sheet".

[3] Sogoba, N.; Feldmann, H.; Safronetz, D. (14 November 2012). "Lassa Fever in West Africa: Evidence for an Expanded Region of Endemicity". Zoonoses & Public Health 59 (59): 43–47. doi:10.1111/j.1863-2378.2012.01469.x.

[4] Yun, N; Walker, D (4 October 2012). "Pathogenesis of Lassa Fever". Viruses 4: 2031–2048. doi:10.3390/v4102031. PMC 3497040. PMID 23202452.

[5] Lashley, Felissa R., and Jerry D. Durham. Emerging Infectious Diseases: Trends and Issues. New York: Springer Pub., 2002. Print.

[6] Ridley, Matt. Genome: The Autobiography of a Species in 23 Chapters. New York: HarperCollins, 1999. Print.

[7] "Lassa virus RefSeq Genome".

[Cornu_2001-8] Cornu, T. I.; De La Torre, J. C. (2001). "RING Finger Z Protein of Lymphocytic Choriomeningitis Virus (LCMV) Inhibits Transcription and RNA Replication of an LCMV S-Segment Minigenome". Journal of Virology 75 (19): 9415–9426. doi:10.1128/JVI.75.19.9415-9426.2001. PMC 114509. PMID 11533204.

[9] Djavani M, et al. (Sep 1997). "Completion of the Lassa fever virus sequence and identification of a RING finger open reading frame at the L RNA 5' End.". Virology 235 (2): 414–8. doi:10.1006/viro.1997.8722.

[Cao_1998-10] Cao, W.; Henry, M. D.; Borrow, P.; Yamada, H.; Elder, J. H.; Ravkov, E. V.; Nichol, S. T.; Compans, R. W.; Campbell, K. P.; Oldstone, M. B. (1998). "Identification of -Dystroglycan as a Receptor for Lymphocytic Choriomeningitis Virus and Lassa Fever Virus". Science 282 (5396): 2079–2081. doi:10.1126/science.282.5396.2079. PMID 9851928.

[11] Lashley, Felissa (2002). Emerging Infectious Diseases Trends and Issues. Springer Publishing Company.

[Bowen_2000-12] Bowen MD, Rollin PE, Ksiazek TG, et al. (August 2000). "Genetic Diversity among Lassa Virus Strains". J. Virol. 74 (15): 6992–7004. doi:10.1128/JVI.74.15.6992-7004.2000. PMC 112216. PMID 10888638.

[Rojek_2008-13] Rojek JM, Kunz S (April 2008). "Cell Entry by Human Pathogenic Arenaviruses". Cell Microbiol. 10 (4): 828–35. doi:10.1111/j.1462-5822.2007.01113.x. PMID 18182084.

[Drosten_2003-14] Drosten C, Kümmerer BM, Schmitz H, Günther S (January 2003). "Molecular Diagnostics of Viral Hemorrhagic Fevers". Antivural Res. 57 (1-2): 61–87. doi:10.1016/s0166-3542(02)00201-2. PMID 12615304.

[Yun_2012-15] Yun NE, Walker DH (October 2012). "Pathogenesis of Lassa Fever". Viuses. 4 (10): 2031–48. doi:10.3390/v4102031. PMC 3497040. PMID 23202452.

[Luka_1999-16] Levene, M. I.; Gibson, N. A.; Fenton, A. C.; Papathoma, E.; Barnett, D. (1990). "The use of a calcium-channel blocker, nicardipine, for severely asphyxiated newborn infants". Developmental medicine and child neurology 32 (7): 567–574. PMID 2391009.

[Mahanty_2003-17] Mahanty, S.; Hutchinson, K.; Agarwal, S.; McRae, M.; Rollin, P. E.; Pulendran, B. (2003). "Cutting edge: Impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses". Journal of immunology (Baltimore, Md. : 1950) 170 (6): 2797–2801. doi:10.4049/jimmunol.170.6.2797. PMID 12626527.

[Baize_2004-18] Baize, S.; Kaplon, J.; Faure, C.; Pannetier, D.; Georges-Courbot, M. C.; Deubel, V. (2004). "Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells". Journal of immunology (Baltimore, Md. : 1950) 172 (5): 2861–2869. doi:10.4049/jimmunol.172.5.2861. PMID 14978087.

[Hastie_2012-19] Hastie KM, Bale S, Kimberlin CR, Saphire EO (April 2012). "Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses". Current Opinion in Virology 2 (2): 151–6. doi:10.1016/j.coviro.2012.01.003. PMID 22482712.

[20] Donaldson, Ross I. (2009). The Lassa Ward:One Man's Fight Against One of the World's Deadliest Diseases. St. Martin's Press. ISBN 0-312-37700-2. ISBN 978-0-312-37700-7.

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Lassa virus