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- escitalopram
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English Journal
- Decreased platelet 5-hydroxytryptamin (5-HT) levels: a response to antidepressants.
- Li X1, Fan Y1, Xiao S1, Peng S1, Dong X2, Zheng X2, Liu CC3, Li H4, Xiao Z5.
- Journal of affective disorders.J Affect Disord.2015 Nov 15;187:84-90. doi: 10.1016/j.jad.2015.08.025. Epub 2015 Aug 21.
- BACKGROUND: Platelet 5-hydroxytryptamin (serotonin, 5-HT) has been examined for its use as a peripheral biomarker for depression or other mental disorders; however, it remains unclear whether blood 5-HT levels can reflect the brain's levels of serotonin.METHODS: Platelet 5-HT levels in 45 drug-naïv
- PMID 26321259
- Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes.
- Lassila T1, Rousu T2, Mattila S2, Chesné C3, Pelkonen O4, Turpeinen M4, Tolonen A5.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2015 Nov 10;115:345-51. doi: 10.1016/j.jpba.2015.07.020. Epub 2015 Jul 26.
- The objective was to compare several in vitro human liver-derived subcellular and cellular incubation systems for the formation of GSH-trapped reactive metabolites. Incubations of pooled human liver microsomes, human liver S9 fractions, HepaRG-cells, and human hepatocytes were performed with glutath
- PMID 26263063
- Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.
- Teixeira-Castro A1, Jalles A2, Esteves S2, Kang S3, da Silva Santos L4, Silva-Fernandes A4, Neto MF5, Brielmann RM5, Bessa C4, Duarte-Silva S4, Miranda A4, Oliveira S4, Neves-Carvalho A4, Bessa J4, Summavielle T6, Silverman RB3, Oliveira P7, Morimoto RI5, Maciel P2.
- Brain : a journal of neurology.Brain.2015 Nov;138(Pt 11):3221-37. doi: 10.1093/brain/awv262. Epub 2015 Sep 15.
- Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective seroto
- PMID 26373603
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