L-リジン-6-トランスアミナーゼ
WordNet
- the 12th letter of the Roman alphabet (同)l
- a class of transferases that catalyze transamination (that transfer an amino group from an amino acid to another compound) (同)aminotransferase, aminopherase
- any substance (such as an antibody) or agent that can cause lysis
- an essential amino acid found in proteins; occurs especially in gelatin and casein
PrepTutorEJDIC
- lira(イタリアの貨幣単位リラ)
- リジン(細胞溶解素), = lysine
- liter[s]
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/11 21:11:07」(JST)
[Wiki en表示]
| L-lysine 6-transaminase |
| Identifiers |
| EC number |
2.6.1.36 |
| CAS number |
9054-68-6 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a L-lysine 6-transaminase (EC 2.6.1.36) is an enzyme that catalyzes the chemical reaction
- L-lysine + 2-oxoglutarate 2-aminoadipate 6-semialdehyde + L-glutamate
Thus, the two substrates of this enzyme are L-lysine and 2-oxoglutarate, whereas its two products are 2-aminoadipate 6-semialdehyde and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-lysine:2-oxoglutarate 6-aminotransferase. Other names in common use include lysine 6-aminotransferase, lysine epsilon-aminotransferase, lysine epsilon-transaminase, lysine:2-ketoglutarate 6-aminotransferase, L-lysine-alpha-ketoglutarate aminotransferase, and L-lysine-alpha-ketoglutarate 6-aminotransferase. This enzyme participates in lysine biosynthesis. It employs one cofactor, pyridoxal phosphate.
References
- Soda K, Misono H, Yamamoto T (1968). "L-Lysine:alpha-ketoglutarate aminotransferase. I. Identification of a product, delta-1-piperideine-6-carboxylic acid". Biochemistry. 7 (11): 4102–9. doi:10.1021/bi00851a045. PMID 5722275.
- Soda K, Misono H (1968). "L-Lysine:alpha-ketoglutarate aminotransferase. II. Purification, crystallization, and properties". Biochemistry. 7 (11): 4110–9. doi:10.1021/bi00851a046. PMID 5722276.
|
Transferase: nitrogenous groups (EC 2.6)
|
|
| 2.6.1: Transaminases |
- Aspartate transaminase
- Alanine transaminase
- GABA transaminase
- Tyrosine aminotransferase
- Ornithine aminotransferase
- Branched chain aminotransferase
- Alanine—glyoxylate transaminase
|
|
| 2.6.3: Oximinotransferases |
|
|
| 2.6.99: Other |
- Pyridoxine 5'-phosphate synthase
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15-99
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
|
Proteins: enzymes
|
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
|
| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15-99
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Enzymatic preparation of 5-hydroxy-L-proline, N-Cbz-5-hydroxy-L-proline, and N-Boc-5-hydroxy-L-proline from (α-N-protected)-L-ornithine using a transaminase or an amine oxidase.
- Hanson RL1, Johnston RM, Goldberg SL, Parker WL, Patel RN.
- Enzyme and microbial technology.Enzyme Microb Technol.2011 May 6;48(6-7):445-53. doi: 10.1016/j.enzmictec.2011.03.007. Epub 2011 Mar 26.
- N-Cbz-4,5-dehydro-L-prolineamide or N-Boc-4,5-dehydro-L-prolineamide are alternative key intermediates for the synthesis of saxagliptin, a dipeptidyl peptidase IV (DPP4) inhibitor recently approved for treatment of type 2 diabetes mellitus. An efficient biocatalytic method was developed for conversi
- PMID 22113015
- Identification of the initial steps in D-lysine catabolism in Pseudomonas putida.
- Revelles O1, Wittich RM, Ramos JL.
- Journal of bacteriology.J Bacteriol.2007 Apr;189(7):2787-92. Epub 2007 Jan 26.
- Pseudomonas putida uses l-lysine as the sole carbon and nitrogen source which preferentially requires its metabolism through two parallel pathways. In one of the pathways delta-aminovalerate is the key metabolite, whereas in the other l-lysine is racemized to d-lysine, and l-pipecolate and alpha-ami
- PMID 17259313
- Synthesis of 1-piperideine-6-carboxylic acid produced by L-lysine-epsilon-aminotransferase from the Streptomyces clavuligerus gene expressed in Escherichia coli.
- Wu ML1, Chen JH, Ho CT, Huang TC.
- Journal of agricultural and food chemistry.J Agric Food Chem.2007 Mar 7;55(5):1767-72. Epub 2007 Feb 9.
- The gene (lat) encoding L-lysine epsilon-aminotransferase (LAT) in Streptomyces clavuligerus was cloned and expressed in Escherichia coli. Nucleotide sequence analysis of lat predicted a single open reading frame (ORF) of 1371 bp, encoding a polypeptide of 457 amino acids with calculated molecular m
- PMID 17288446
Related Links
- 一時的に在庫切れ; 入荷時期は未定です。 在庫状況について 注文確定後、入荷時期が確定次第、お届け予定日をEメールでお知らせし
- Definition of L-Lysine 6-Transaminase in the Definitions.net dictionary. Meaning of L-Lysine 6-Transaminase. What does L-Lysine 6-Transaminase mean? Information and translations of L-Lysine 6-Transaminase in the most ...
★リンクテーブル★
[★]
- 英
- L-lysine 6-transaminase
[★]
[★]
トランスアミナーゼ