クンジンウイルス、Kunjinウイルス
- 関
- West Nile virus
WordNet
- a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
- (virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
- a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
PrepTutorEJDIC
- ビールス,ろ過性病原体
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/16 05:39:19」(JST)
[Wiki en表示]
| Kunjin virus |
| Virus classification |
| Group: |
Group IV ((+)ssRNA) |
| Order: |
Unassigned |
| Family: |
Flaviviridae |
| Genus: |
Flavivirus |
| Species: |
West Nile virus |
Kunjin virus (KUNV) is a zoonotic virus of the family Flaviviridae and the genus Flavivirus. It is a subtype of West Nile Virus endemic to Oceania.
Contents
- 1 History
- 2 Virology
- 3 Symptoms and prognosis
- 4 Transmission and control
- 5 Use in medicine
- 6 References
History[edit]
The virus was first isolated from Culex annulirostris mosquitoes in Australia in 1960.[1][2] The name of Kunjin virus derives from an Aboriginal clan living on the Mitchell River close to where the virus was first isolated in Kowanyama, northern Queensland.[1][3]
Virology[edit]
Kunjin virus is a zoonotic virus of the family Flaviviridae and the genus Flavivirus. It is an arbovirus which is transmitted by mosquitoes and is part of the Japanese encephalitis serological complex.[4] It is antigenically and genetically very similar to West Nile virus and in 1999 was reclassified as a subtype of WNV.[3][5] Its genome is positive-sense single stranded RNA made up of 10,644 nucleotides.[3][4]
Symptoms and prognosis[edit]
Infection with the virus often causes no symptoms, but it can lead to either an encephalitic disease or a non-encephalitic disease.[6] Non-encephalitic Kunjin virus disease can cause symptoms including acute febrile illness, headache, arthralgia, myalgia, fatigue and rash.[1][6] Kunjin virus encephalitis features acute febrile meningoencephalitis.[1]
Both forms of Kunjin virus disease are milder than the diseases caused by West Nile virus and Murray Valley encephalitis virus.[5][6]
Transmission and control[edit]
Kunjin virus is transmitted by mosquito vectors, especially the Culex annulirostris.[3] They pass the virus to waterbird reservoir hosts; a major example is the Nankeen Night Heron.[3] It is also passed to horses and humans.[7] The virus been isolated in mosquitoes in South East Asia but in humans, only in Australia.[6] It has been found all over Australia and is particularly prevalent in areas near wetlands and rivers.[8]
The control of Kunjin virus is achieved in the same ways as other mosquito-borne diseases. These include individuals using insect repellent, wearing long-sleeved clothes and avoiding areas where mosquitoes are particularly prevalent.[1] Habitat control by government agencies can take the form of reducing the amount of water available for mosquitoes to breed in, and the use of insecticides.[9] There is no available vaccine against Kunjin virus.[1]
Use in medicine[edit]
In 2005, scientists at the Queensland Institute of Medical Research and the University of Queensland found that modified Kunjin virus particles injected into mice were able to deliver a gene into the immune system targeting cancer cells.[10][11] This research may lead to vaccines for cancer and HIV.[10][11]
References[edit]
- ^ a b c d e f "Department of Health and Ageing — Kunjin virus infection — Fact Sheet". Government of Australia. 2004-05-25. Retrieved 2009-08-08. [dead link]
- ^ Krauss, H. (2003). Zoonoses. ASM Press. p. 45. ISBN 1-55581-236-8.
- ^ a b c d e Mackenzie, John S.; R. W. Ashford, M. W. Service (2001). Encyclopedia of arthropod-transmitted infections of man and domesticated animals. CABI. p. 251. ISBN 0-85199-473-3.
- ^ a b Hirsh, Dwight C.; Nigel James Maclachlan, Richard L. Walker (2004). Veterinary microbiology. Wiley-Blackwell. p. 354. ISBN 0-8138-0379-9.
- ^ a b Bhattacharya, Shaoni (2003-08-12). "West Nile Virus's milder cousin gives vaccine hope". New Scientist. Retrieved 2009-08-08
- ^ a b c d Cook, Gordon C.; Alimuddin I. Zumla (2008). Manson's tropical diseases. Elsevier Health Sciences. pp. 736–7. ISBN 1-4160-4470-1.
- ^ Scherret, Jacqueline H.; Michael Poidinger (Jul–Aug 2001). "The Relationships between West Nile and Kunjin Viruses". Centers for Disease Control and Prevention. Retrieved 2009-08-08.
- ^ Adlam, Nigel (2008-03-20). "Heavy rains bring mozzie diseases". Northern Territory News. Retrieved 2009-08-08
- ^ Russell, Richard C.; Stephen L. Doggett. "Murray Valley Encephalitis virus & Kunjin virus". University of Sydney — Department of Medical Entomology. Retrieved 2009-08-08.
- ^ a b "Australian virus may lead to cancer vaccine". Australian Broadcasting Corporation. 2005-03-31. Retrieved 2009-08-08
- ^ a b "New medical uses for the Kunjin virus". News-Medical.Net. 2005-04-12. Retrieved 2009-08-08
|
Zoonotic viral diseases (A80–B34, 042–079)
|
|
| Arthropod-borne |
| Mosquito-borne |
| Bunyaviridae |
- Arbovirus encephalitides: La Crosse encephalitis
- California encephalitis
- Viral hemorrhagic fevers: Rift Valley fever
|
|
| Flaviviridae |
- Arbovirus encephalitides: Japanese encephalitis
- Australian encephalitis
- Saint Louis encephalitis
- West Nile fever
- Viral hemorrhagic fevers: Dengue fever
- Yellow fever
- ZIKV
|
|
| Togaviridae |
- Arbovirus encephalitides: Eastern equine encephalomyelitis
- Western equine encephalomyelitis
- Venezuelan equine encephalomyelitis
- Chikungunya
- O'Nyong-nyong fever
- Ross River fever
|
|
|
| Tick-borne |
| Bunyaviridae |
- Viral hemorrhagic fevers: Crimean-Congo hemorrhagic fever
|
|
| Flaviviridae |
- Arbovirus encephalitides: Tick-borne encephalitis
- Powassan encephalitis
- Viral hemorrhagic fevers: Omsk hemorrhagic fever
- Kyasanur forest disease
- Langat virus (LGTV)
|
|
| Reoviridae |
|
|
|
|
| Mammal-borne |
| Rodent-borne |
| Arenaviridae |
- Viral hemorrhagic fevers: Lassa fever
- Venezuelan hemorrhagic fever
- Argentine hemorrhagic fever
- Brazilian hemorrhagic fever
- Bolivian hemorrhagic fever
- LUJV
- CHPV
|
|
| Bunyaviridae |
- Hemorrhagic fever with renal syndrome
- Hantavirus pulmonary syndrome
|
|
|
| Bat-borne |
| Filoviridae |
- Viral hemorrhagic fevers: Ebola virus disease
- Marburg virus disease
|
|
| Rhabdoviridae |
|
|
| Paramyxoviridae |
|
|
|
| Multiple vectors |
|
|
|
|
|
|
cutn/syst (hppv/hiva, infl/zost/zoon)/epon
|
drug (dnaa, rnaa, rtva, vacc)
|
|
|
|
UpToDate Contents
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English Journal
- Replication of Many Human Viruses Is Refractory to Inhibition by Endogenous Cellular MicroRNAs.
- Bogerd HP1, Skalsky RL1, Kennedy EM1, Furuse Y1, Whisnant AW1, Flores O1, Schultz KL2, Putnam N2, Barrows NJ1, Sherry B3, Scholle F4, Garcia-Blanco MA1, Griffin DE2, Cullen BR5.
- Journal of virology.J Virol.2014 Jul 15;88(14):8065-76. doi: 10.1128/JVI.00985-14. Epub 2014 May 7.
- The issue of whether viruses are subject to restriction by endogenous microRNAs (miRNAs) and/or by virus-induced small interfering RNAs (siRNAs) in infected human somatic cells has been controversial. Here, we address this question in two ways. First, using deep sequencing, we demonstrate that infec
- PMID 24807715
- Specificities of Human CD4+ T Cell Responses to an Inactivated Flavivirus Vaccine and Infection: Correlation with Structure and Epitope Prediction.
- Schwaiger J1, Aberle JH1, Stiasny K1, Knapp B2, Schreiner W3, Fae I4, Fischer G4, Scheinost O5, Chmelik V6, Heinz FX7.
- Journal of virology.J Virol.2014 Jul 15;88(14):7828-42. doi: 10.1128/JVI.00196-14. Epub 2014 Apr 30.
- Tick-borne encephalitis (TBE) virus is endemic in large parts of Europe and Central and Eastern Asia and causes more than 10,000 annual cases of neurological disease in humans. It is closely related to the mosquito-borne yellow fever, dengue, Japanese encephalitis, and West Nile viruses, and vaccina
- PMID 24789782
- Undiagnosed acute viral febrile illnesses, sierra leone.
- Schoepp RJ, Rossi CA, Khan SH, Goba A, Fair JN.
- Emerging infectious diseases.Emerg Infect Dis.2014 Jul;20(7):1176-82. doi: 10.3201/eid2007.131265.
- Sierra Leone in West Africa is in a Lassa fever-hyperendemic region that also includes Guinea and Liberia. Each year, suspected Lassa fever cases result in submission of ≈500-700 samples to the Kenema Government Hospital Lassa Diagnostic Laboratory in eastern Sierra Leone. Generally only 30%-40% o
- PMID 24959946
Japanese Journal
- Assembly and maturation of the flavivirus Kunjin virus appear to occur in the rough endoplasmic reticulum and along the secretory pathway, respectively
- Ultrastructure of Kunjin virus-infected cells : colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures
- Glycosylation and antigenic variation among Kunjin virus isolates
Related Links
- What is Kunjin virus disease? Kunjin virus disease is a viral infection caused by a flavivirus (Kunjin virus) found in mainland Australia and Papua New Guinea. It is closely related to West Nile virus which is found in Africa, Europe and ...
- West Nile Virus Definition West Nile virus is a mosquito-borne viral illness that can manifest with varying seriousness, ranging from no symptoms or mild flu-like symptoms to brain damage and death. Description West Nile virus ...
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