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English Journal

STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells.

Gonzales-van Horn SR1, Estrada LD1, van Oers NS1, Farrar JD1.
European journal of immunology.Eur J Immunol.2016 Mar 16. doi: 10.1002/eji.201546050. [Epub ahead of print]
Type I Interferon (IFN-α/β) plays a critical role in suppressing viral replication by driving the transcription of hundreds of interferon sensitive genes (ISGs). While many ISGs are transcriptionally activated by the ISGF3 complex, the significance of other signaling intermediates in IFN-α/β-med
PMID 26990433

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells.

Duerr CU1, McCarthy CD2, Mindt BC1, Rubio M3, Meli AP4, Pothlichet J5, Eva MM6, Gauchat JF7, Qureshi ST8, Mazer BD9, Mossman KL10, Malo D6,11, Gamero AM12, Vidal SM6,11, King IL4, Sarfati M3,13, Fritz JH1,2.
Nature immunology.Nat Immunol.2016 Jan;17(1):65-75. doi: 10.1038/ni.3308. Epub 2015 Nov 23.
Viral respiratory tract infections are the main causative agents of the onset of infection-induced asthma and asthma exacerbations that remain mechanistically unexplained. Here we found that deficiency in signaling via type I interferon receptor led to deregulated activation of group 2 innate lympho
PMID 26595887

Transcriptome comparative analysis revealed poly(I:C) activated RIG-I/MDA5-mediated signaling pathway in miiuy croaker.

Chu Q1, Gao Y2, Xu G1, Wu C3, Xu T4.
Fish & shellfish immunology.Fish Shellfish Immunol.2015 Nov;47(1):168-74. doi: 10.1016/j.fsi.2015.08.032. Epub 2015 Aug 31.
Miiuy croker (Miichthys miiuy) as an important economical aquaculture species has challenged many more diseases caused by various pathogens recently. To better explore the immune response to virus, we have analyzed the transcriptome profiling of miiuy croaker challenged with poly(I:C) synthetic anal
PMID 26334792

Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells

Takeshita Shigeyuki,Ichikawa Tatsuki,Taura Naota,Miyaaki Hisamitsu,Matsuzaki Toshihisa,Otani Masashi,Muraoka Toru,Akiyama Motohisa,Miuma Satoshi,Ozawa Eisuke,Ikeda Masanori,Kato Nobuyuki,Isomoto Hajime,Takeshima Fuminao,Nakao Kazuhiko
Journal of Gastroenterology 47(2), 195-202, 2012-02
… GGA acts as a potent inducer of anti-viral gene expression by stimulating ISGF3 formation in human hepatoma cells. …
NAID 120005121743

Development of Interferon-α Resistant Subline from Human Chronic Myelogenous Leukemia Cell Line KT-1

Yamauchi Hayato,Sakai Ikuya,Narumi Hirosi [他],TAKEUCHI Kazuto,SOGA Shinji,FUJITA Shigeru
Internal medicine 40(7), 607-612, 2001-07
… The induction of the ISGF3 complex in response to IFNα in KT-1/A3Rα 1000 was compared with that in the parental cell. … Results The levels of interferon-stimulated gene factor 3 components (STAT1, STAT2, and p48) proteins and STAT2 tyrosine phosphorylation induced after IFN-α treatment were unchanged, but formation of the ISGF3 complex was remarkably reduced in KT-1/A3Rα 1000 cells compared to parental cells. …
NAID 130000767677