Part 1. Laboratory Hematology | ||
1. Examination of Blood and Bone Marrow | 3 | |
2. Clusters of Differentiation | 27 | |
3. Clinical Flow Cytometry | 99 | |
4. Cytogenetics | 131 | |
5. Molecular Genetics and Hematology | 153 | |
Part 2. The Normal Hematologic System | ||
6. Origin and Development of Blood Cells | 169 | |
7. Erythropoiesis | 195 | |
8. The Mature Erythrocyte | 217 | |
9. Destruction of Erythrocytes | 249 | |
10. Neutrophilic Leukocytes | 267 | |
11. The Human Eosinophils | 311 | |
12. Basophilic Leukocytes: Mast Cells and Basophils | 335 | |
13. Mononuclear Phagocytes | 349 | |
14. Phagocytosis | 387 | |
15. The Lymphatic System | 409 | |
16. B Lymphocytes | 439 | |
17. T Lymphocytes and NK Cells | 475 | |
18. Cell Interactions in the Immune Response | 527 | |
19. Platelets and Megakaryocytes | 605 | |
20. Platelet Function in Hemostasis and Thrombosis | 651 | |
21. Blood Coagulation and Fibrinolysis | 677 | |
22. Endothelium and the Regulation of Hemostasis | 775 | |
Part 3. Therapeutic Modalities | 791 | |
23. Red Cell, Platelet, and White Cell Antigens | 831 | |
24. Transfusion Medicine | 883 | |
25. Hematopoietic Stem Cell Transplantation | 911 | |
26. Gene Therapy | 947 | |
Part 4. Disorders of Red Cells | ||
27. Diagnostic Approach to Anemia | 947 | |
28. Iron Deficiency and Related Disorders | 979 | |
29. Sideroblastic Anemias | 1011 | |
30. Hemochromatosis | 1035 | |
31. Porphyria | 1057 | |
32. Hemolytic Disorders: General Considerations | 1089 | |
33. Hereditary Spherocytosis and Other Anemias Due to Abnormalities | 1115 | |
34. Hereditary Hemolytic Anemias Due to Enzyme Abnormalities | 1141 | |
35. Alloimmune Hemolytic Disease of the Fetus and Newborn | 1157 | |
36. Autoimmune Hemolytic Anemias | 1183 | |
37. Paroxysmal Nocturnal Hemoglobinuria | 1203 | |
38. Acquired Non-Immune Hemolytic Disorders | 1223 | |
39. The Abnormal Hemoglobins: General Principles | 1247 | |
40. Sickle Cell Anemia and Other Sickling Syndromes | 1263 | |
41. Unstable Hemoglobin Disease | 1313 | |
42. The Thalassemias and Related Disorders: Quantitative Disorders | 1319 | |
43. Megaloblastic Anemias: Disorders of Impaired DNA Synthesis | 1367 | |
44. Acquired and Congenital Aplastic Anemia Syndromes | 1397 | |
45. Pure Red Cell Aplasia in Children and Adults | 1421 | |
46. Congenital Dyserythropoietic Anemias | 1439 | |
47. Anemias Secondary to Chronic Disease and Systemic Disorders | 1445 | |
48. Anemias Unique to Pregnancy and the Perinatal Period | 1467 | |
49. Methemoglobinemia | 1487 | |
50. Erythrocytosis | 1495 | |
Part 5. Disorders of Hemostasis and Coagulation | ||
51. The Diagnostic Approach to the Bleeding Disorders | 1511 | |
52. Thrombocytopenia: Pathophysiology/Classification | 1529 | |
53. Thrombocytopenia Caused by Immunolgic Platelet Destruction | 1533 | |
54. Thrombotic Thrombocytopenic Purpura and Other Forms of Nonimmunologic Platelet Destruction | 1555 | |
55. Miscellaneous Causes of Thrombocytopenia | 1565 | |
56. Bleeding Disorders Caused by Vascular Abnormalities | 1573 | |
57. Thrombocytosis | 1591 | |
58. Qualitative Disorders of Platelet Function | 1603 | |
59. Inherited Coagulation Disorders | 1619 | |
60. Acquired Coagulation Disorders | 1669 | |
61. Thrombosis and Antithrombotic Therapy | 1713 | |
Part 6. Nonmalignant Disorders of Leukocytes, the Spleen, and/or Immunoglobins | ||
62. Diagnostic Approach to Disorders… | 1761 | |
63. Neutropenia | 1777 | |
64. Qualitative Disorders of Leukocytes | 1801 | |
65. Abnormalities of the Monocyte-Macrophage System: The Lysosomal Storage Disease | 1819 | |
66. Langerhans Cell Histiocytosis | 1827 | |
67. Infectious Mononucleosis and Other EBV-Related Disorders | 1837 | |
68. Congenital Immune Deficiencies | 1863 | |
69. Acquired Immunodeficiency Disease | 1875 | |
70. Disorders of the Spleen | 1893 | |
Part 7. Hematologic Malignancies | ||
71. The Hematopoietic and Lymphoid Neoplasms: Principles of Diagnosis | 1913 | |
72. Complications of Hematopoietic Neoplasms | 1919 | |
73. Principles and Pharmacology of Chemotherapy | 1945 | |
74. Immunotherapy | 1971 | |
75. Supportive Care in Hematologic Malignancies | 1997 | |
76. Classification and Differentiation of the Acute Leukemias | 2045 | |
77. Molecular Genetics of Acute Leukemia | 2063 | |
78. Acute Lymphocytic Leukemia in Children | 2077 | |
79. Acute Lymphocytic Leukemia in Adults | 2097 | |
80. Acute Myelogenous Leukemia in Adults | 2143 | |
81. Acute Myelogenous Leukemia in Children | 2169 | |
82. Acute Promyelocytic Leukemia | 2191 | |
83. The Myelodysplastic Syndromes | 2207 | |
84. Chronic Myeloid Leukemia | 2235 | |
85. Polycythemia Vera | 2259 | |
86. Myelofibrosis | 2273 | |
87. Systemic Mastocytosis | 2285 | |
88. Diagnosis and Classification of Lymphoproliferative Disorders | 2301 | |
89. Molecular Aspects of Non-Hodgkin Lymphomagenesis | 2325 | |
90. Non-Hodgkin Lymphomas in Adults | 2363 | |
91. Non-Hodgkin Lymphomas in Children | 2411 | |
92. Chronic Lymphocytic Leukemia | 2429 | |
93. Hairy Cell Leukemia | 2465 | |
94. Cutaneous T-Cell Lymphomas: Mycosis Fungiodes and Sezary Syndrome | 2485 | |
95. Hodgkin Disease | 2521 | |
96. Plasma Cell Disorders: General Considerations | 2555 | |
97. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma | 2565 | |
98. Multiple Myeloma | 2583 | |
99. Amyloidosis | 2637 | |
100. Waldenstrom's Macroglobulinemia | 2667 | |
101. Cryoglobulinemia, Heavy Chain Diseases, and Monoclonal Gammopath-Associated Disorders | 2683 | |
Appendies | ||
Appendix A. Normal Blood and Bone Marrow Values in Humans | 2697 | |
Appendix B. Comparative Hematology | 2707 |
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