Section 1: General Principles		1
	1. Pharmacokinetics and Pharmacodynamics	1
	2. Drug Transport/Drug Transporters	41
	3. Drug Metabolism	71
	4. Pharmacogenomics	93
	5. Principles of Therapeutics	117
Section 2: Drugs Acting at Synaptic and Neuroeffector Junctional Sites		137
	6. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems	137
	7. Muscarinic Receptor Agonists and Antagonists	183
	8. Anticholinesterase Agents	201
	9. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia	217
	10. Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists	237
	11. 5-Hydroxytryptamine (Serotonin) Receptor Agonists and Antagonists	297
Section 3: Drugs Acting on the Central Nervous System		317
	12. Neurotransmission and the Central Nervous System	317
	13. History and Principles of Anesthesiology; General Anesthetics	341
	14. Local Anesthetics	369
	15. The Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium	387
	16. Hypnotics and Sedatives	401
	17. Introduction to Psychopharmacology: Drug Therapy of Depression and Anxiety Disorders	429
	18. Pharmacotherapy of Psychosis and Mania	461
	19. Drugs Effective in the Therapy of the Epilepsies	501
	20. Treatment of Central Nervous System Degenerative Disorders	527
	21. Opioid Analgesics	547
	22. Ethanol	591
	23. Drug Addiction and Drug Abuse	607
Section 4: Autacoids: Drug therapy of Inflammation		629
	24. Histamine, Bradykinin, and Their Antagonists	629
	25. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor	653
	26. Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout	671
	27. Drugs Used in the Treatment of Asthma	717
Section 5: Drugs Affecting Renal and Cardiovascular Function		737
	28. Diuretics	737
	29. Vasopressin and Other Agents Affecting the Renal Conservation of Water	771
	30. Renin and Angiotensin	789
	31. Drugs Used for the Treatment of Myocardial Ischemia	823
	32. Antihypertensive Agents and the Drug Therapy of Hypertension	845
	33. Pharmacological Treatment of Heart Failure	869
	34. Antiarrhythmic Drugs	899
	35. Drug Therapy for Hypercholesterolemia and Dyslipidemia	933
Section 6: Drugs Affecting Gastrointestinal Function		967
	36. Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesopheageal Reflux Disease	967
	37. Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome	983
	38. Agents Used of Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease	1009
Section 7: Chemotherapy of Parasitic Infections		1021
	39. Drugs Used in the Chemotherapy of Protozoal Infections: Malaria	1021
	40. Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections	1049
	41. Drugs Used in the Chemotherapy of Helminthiasis	1073
Section 8: Chemotherapy of Microbial Diseases		1095
	42. General Considerations	1095
	43. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections	1111
	44. Penicillins, Cephalosporins, and Other b-Lactam Antibiotics	1127
	45. The Aminoglycosides	1155
	46. Protein-Synthesis Inhibitors and Miscellaneous Antibacterial Agents	1173
	47. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy	1203
	48. Antifungal Agents	1225
	49. Antiviral Agents (Nonretroviral)	1243
	50. Antiretroviral Agents	1273
Section 9: Chemotherapy of Neoplastic Diseases		1315
	51. Antineoplastic Agents	1315
Section 10: Drugs Used for Immunomodulation		1405
	52. Imunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants	1405
Section 11: Drugs Acting on the Blood and the Blood-Forming Organs		1433
	53. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins	1433
	54. Blood Coagulation and Anticoagulant, Thrombolytic, and Antiplatelet Drugs	1467
Section 12: Hormones and hormone Antagonists		1489
	55. Pituitary Hormones and Their Hypothalamic Releasing Factors	1489
	56. Thyroid and Antithyroid Drugs	1511
	57. Estrogens and Progestins	1545
	58. Androgens	1573
	59. Adrenocorticotropic Hormone; 　Adrenocortical Steroids and Their Synthetic Analogs; 　Inhibitors of the Synthesis and Actions of Adrenocortical Hormones	1587
	60. Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas	1613
	61. Agents Affecting Calcification and Bone Turnover: 　Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds	1647
Section 13: Dermatology		1679
	62. Dermatological Pharmacology	1679
Section 14: Ophthalmology		1707
	63. Ocular Pharmacology	1707
Section 15: Toxicology		1739
	64. Principles of Toxicology; Treatment of Poisoning	1739
	65. Poisoning; Heavy Metals and Heavy-Metal Antagonists	1753
Appendices		1777
	Principles of Prescription Order Writing and Patient Compliance	1777
	Disign and Optimization of Dosage Regimens; Pharmacokinetic Data	1787