- 関
- interleukin-1 receptor-associated kinase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/01/03 11:39:06」(JST)
[Wiki en表示]
interleukin-1 receptor-associated kinase 4 |
Identifiers |
Symbol |
IRAK4 |
Entrez |
51135 |
HUGO |
17967 |
OMIM |
606883 |
RefSeq |
NM_016123 |
UniProt |
Q9NWZ3 |
Other data |
Locus |
Chr. 12 q12 |
IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors.
Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.
Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations
External links
- IRAK4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
Signaling pathway: TLR signaling pathway
|
|
Receptor |
|
|
Other external |
|
|
Internal |
- adaptor: MYD88
- TRIF
- TIRAP
- TRAF6
- TOLLIP
|
|
|
|
|
|
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease.
- Cameron B, Tse W, Lamb R, Li X, Lamb BT, Landreth GE.SourceDepartment of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106; Departments of Immunology and Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio 44195; and Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106.
- The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2012 Oct 24;32(43):15112-23. doi: 10.1523/JNEUROSCI.1729-12.2012.
- Alzheimer's disease (AD) is typified by the deposition of amyloid in the brain, which elicits a robust microglial-mediated inflammatory response that is associated with disease exacerbation and accelerated progression. Microglia are the principal immune effector cells in the brain and interact with
- PMID 23100432
Japanese Journal
- 特定の病原体に易感染性を示す原発性免疫不全症候群 (ミニ特集 原発性免疫不全症の診断と治療Update)
- 自然免疫異常 : MyD88/IRAK4欠損症,免疫不全を伴う無汗性外胚葉形成異常 (特集 知っておきたい最新の免疫不全症分類 : 診断から治療まで) -- (病態)
- O35-2 IRAK4欠損症,MyD88欠損症の全国症例調査及び診断・治療方法の確立に向けた解析(小児アレルギー2,口演,第62回日本アレルギー学会秋季学術大会)
Related Links
- Interleukin-1 receptor associated kinase (IRAK) 4は、2002年にそのノックアウトマウスが発表された。IRAK4欠損マウスでは、IL-1R IL-18R刺激、TLR 刺激 (TLR 2, 3, 4, 9) に対する反応が欠損し、ブドウ球菌に対する感染抵抗性が著しく低下 ...
- 免疫系疾患分野 インターロイキン1受容体関連キナーゼ4(IRAK4)欠損症 1.概要 インターロイキン1受容体関連キナーゼ4(IRAK4)欠損症は、2003年にPicardらによって初めて報告さ れた疾患で、Toll様受容体(TLR)のシグナル伝達を担う分子 ...
Related Pictures
★リンクテーブル★
[★]
- 同
- interleukin-1 receptor-associated kinase 4
[★]
- 関
- interleukin-1 receptor-associated kinase