WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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Phosphatidylinositol 3-kinases pathway mediates lung caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma model.

Liang J1, Zhao H1, Yao L1, Tang H1, Dong H1, Wu Y1, Liu L1, Zou F2, Cai S3.
Toxicology letters.Toxicol Lett.2015 Jul 2;236(1):25-33. doi: 10.1016/j.toxlet.2015.04.011. Epub 2015 Apr 27.
We have previously demonstrated that downregulating HMGB1 decreases airway neutrophil inflammation in a toluene-diisocyanate (TDI)-induced murine asthma model, yet how HMGB1 is regulated in the lung remains uncertain. In this study, we intended to explore whether PI3K signaling pathway mediates pulm
PMID 25929181

HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2.

Liang Y1, Hou C, Kong J, Wen H, Zheng X, Wu L, Huang H, Chen Y.
Molecular and cellular biochemistry.Mol Cell Biochem.2015 Jul;405(1-2):63-71. doi: 10.1007/s11010-015-2396-0. Epub 2015 Apr 11.
The proinflammatory factor high mobility group box protein 1 (HMGB1) has been implicated as an important mediator of many chronic inflammatory diseases, including asthma. Human bronchial epithelial cells (HBECs) play a central role in the pathogenesis of asthma. However, the effects of HMGB1 on HBEC
PMID 25862459

Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals.

Kim SR1, Ha YM2, Kim YM1, Park EJ1, Kim JW1, Park SW1, Kim HJ1, Chung HT3, Chang KC4.
Biochemical pharmacology.Biochem Pharmacol.2015 Jun 15;95(4):279-89. doi: 10.1016/j.bcp.2015.04.007. Epub 2015 Apr 17.
High mobility group box 1 (HMGB1) is now recognized as a late mediator of sepsis. We tested hypothesis that ascorbic acid (AscA) induces heme oxygenase (HO)-1 which inhibits HMGB1 release in lipopolysaccharide (LPS)-stimulated cells and increases survival of septic mice. AscA increased HO-1 protein
PMID 25896849

Usefulness of High Mobility Group Box 1 Protein as a Plasma Biomarker in Patient with Peripheral Artery Disease

Oozawa Susumu,Sano Shunji,Nishibori Masahiro
Acta Medica Okayama 68(3), 157-162, 2014-06
… High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator. … The present study was performed to examine the levels of plasma HMGB1 protein in atherosclerosis patients. …
NAID 120005447128

野村昌作
日本造血細胞移植学会雑誌 3(2), 32-38, 2014
… VODを代表とするTACの原因の一つは，HMGB1を含む種々のサイトカインである可能性が高いので，rTMはVODに対する新規治療戦略として有望であると考えられる。 …
NAID 130003397475

Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization

Putranto Endy Widya,Murata Hitoshi,Yamamoto Ken-Ichi,Kataoka Ken,Yamada Hidenori,Futami Jun-Ichiro,Sakaguchi Masakiyo,Huh Nam-Ho
International Journal of Molecular Medicine 32(4), 938-944, 2013-10
… RAGE is involved in a wide range of inflammatory, degenerative and hyper-proliferative disorders which span over different organs by engaging diverse ligands, including advanced glycation end products, S100 family proteins, high-mobility group protein B1 (HMGB1) and amyloid beta. …
NAID 120005425664