WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre

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1. 末梢性T細胞リンパ腫の初期治療 initial treatment of peripheral t cell lymphoma
2. 皮下蜂窩織炎様T細胞性リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of subcutaneous panniculitis like t cell lymphoma
3. ALK陽性未分化大細胞型リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of anaplastic large cell lymphoma alk positive
4. B細胞前リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of b cell prolymphocytic leukemia
5. びまん性大細胞型B細胞性リンパ腫の疫学、臨床症状、病理学的特徴、および診断 epidemiology clinical manifestations pathologic features and diagnosis of diffuse large b cell lymphoma

Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells.

Lee YH, Yuk HJ, Park KH, Bae YS.SourceSchool of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Republic of Korea.
Food chemistry.Food Chem.2013 Nov 1;141(1):381-8. doi: 10.1016/j.foodchem.2013.03.053. Epub 2013 Mar 23.
An inhibitor of the protein kinase CKII (CKII) was purified from leaves of Glycine max (L.) Merrill and was identified as coumestrol by structural analysis. Coumestrol inhibited the phosphotransferase activity of CKII toward β-casein, with an IC50 of about 5μM. It acted as a competitive inhibitor
PMID 23768371

Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells.

Janouskova H, Ray AM, Noulet F, Lelong-Rebel I, Choulier L, Schaffner F, Lehmann M, Martin S, Teisinger J, Dontenwill M.SourceUMR7213 CNRS, Université de Strasbourg, Faculté de Pharmacie, Illkirch, France; Institute of Physiology, Academy of Sciences, Prague, Czech Republic.
Cancer letters.Cancer Lett.2013 Aug 19;336(2):307-18. doi: 10.1016/j.canlet.2013.03.018. Epub 2013 Mar 21.
Integrins emerge nowadays as crucial actors of tumor aggressiveness and resistance to therapies. Integrin α5β1, the fibronectin receptor, determines malignant properties of colon carcinoma which is one of the most important causes of cancer-related deaths in the world. Here we show that inhibition
PMID 23523610

Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen.

Yan ZH, Burkhardt A, Loke HK, Chen J, Xu Q, Brauer P, Ma J, Lin Y, Garcia K, Dick LR, Bembenek ME.SourceMillennium Pharmaceuticals: The Takeda Oncology Company, Cambridge, MA 02139, USA.
Analytical biochemistry.Anal Biochem.2013 Aug 15;439(2):109-15. doi: 10.1016/j.ab.2013.04.016. Epub 2013 Apr 25.
Cellular effects of a Nedd8-activating enzyme (NAE) inhibitor, MLN4924, using the AlphaScreen format were explored. MLN4924 acts as a substrate-assisted inhibitor of NAE by forming a tight binding Nedd8-MLN4924 adduct. The inhibited enzyme can no longer transfer Nedd8 downstream to modify and activa
PMID 23624319

Different Involvement of DNA Methylation and Histone Deacetylation in the Expression of Solute-Carrier Transporters in 4 Colon Cancer Cell Lines

Ikehata Mika,Ueda Kumiko,Iwakawa Seigo
Biological and Pharmaceutical Bulletin 35(3), 301-307, 2012
… Human colon cancer cell lines (HCT116, HT29, SW48, SW480) were treated with 5-aza-2′-deoxycytidine (DAC), as a DNA methyltransferase inhibitor, followed by trichostatin A (TSA), as a histone deacetylase inhibitor. … TSA treatment increased histone H3 acetylation of THTR2 promoter region in all 4 colon cancer cell lines examined. … HCT116 and SW48 cells showed a lack of THTR2 mRNA expression and methylation of its promoter, and DAC treatment induced its re-expression. …
NAID 130001872309

Facile Synthesis and Quantitative Structure–Activity Relationship Study of Antitumor Active 2-(4-Oxo-thiazolidin-2-ylidene)-3-oxo-propionitriles

Hanna Mona Maurice,George Riham François
Chemical and Pharmaceutical Bulletin 60(9), 1195-1206, 2012
… Many of the synthesized compounds exhibited promising antitumor properties against colon HCT116 and breast T47D cell lines. …
NAID 130001852546