同: hepatitis B core antigen

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/12 21:58:58」(JST)

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Schematic overview of the hepatitis B virus particle. HBcAg is a constituent of the nucleocapsid core (green hexagon).

The genome organisation of HBV. Some genes overlap. (ORF Core, at bottom left, encodes HBcAg.

HBcAg (core antigen) is a hepatitis B viral protein.^[1]^[2] It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person (i.e. the person is infectious).

Structure and Function

HBcAg is an antigen can be found on the surface of the nucleocapsid core (the inner most layer of the hepatitis b virus). While both HBcAg and HBeAg are made from the same reading frame, HBcAg is not secreted. HBcAg is considered "particulate" and it does not circulate in the blood. However, it is readily detected in hepatocytes after biopsy. The presence of both HBcAg and HBeAg proteins together act as a marker of viral replication, and antibodies to these antigens are a marker of declining replication.

Interactions

Tapasin can interact with HBcAg18-27 and enhance cytotoxic T lymphocyte response against HBV.^[3]

References

^ Kimura T, Rokuhara A, Matsumoto A, et al. (May 2003). "New enzyme immunoassay for detection of hepatitis B virus core antigen (HBcAg) and relation between levels of HBcAg and HBV DNA". J. Clin. Microbiol. 41 (5): 1901–6. doi:10.1128/JCM.41.5.1901-1906.2003. PMC 154683. PMID 12734224.
^ Cao T, Meuleman P, Desombere I, Sällberg M, Leroux-Roels G (December 2001). "In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model". J. Virol. 75 (23): 11449–56. doi:10.1128/JVI.75.23.11449-11456.2001. PMC 114731. PMID 11689626.
^ Chen X (May 2014). "Tapasin modification on the intracellular epitope HBcAg18-27 enhances HBV-specific CTL immune response and inhibits hepatitis B virus replication in vivo.". Lab Invest. 94 (5): 478–90. doi:10.1038/labinvest.2014.6. PMID 24614195.

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English Journal

CRISPR/Cas9 produces anti-hepatitis B virus effect in hepatoma cells and transgenic mouse.

Zhu W1, Xie K2, Xu Y2, Wang L2, Chen K2, Zhang L2, Fang J3.
Virus research.Virus Res.2016 Jun 2;217:125-32. doi: 10.1016/j.virusres.2016.04.003. Epub 2016 Apr 2.
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PMID 27049051

Design, synthesis, molecular docking studies and anti-HBV activity of phenylpropanoid derivatives.

Liu S1, Li Y2, Wei W3, Wang K4, Wang L5, Wang J5.
Chemico-biological interactions.Chem Biol Interact.2016 May 5;251:1-9. doi: 10.1016/j.cbi.2016.03.011. Epub 2016 Mar 12.
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PMID 26980103

Proteasomes regulate hepatitis B virus replication by degradation of viral core-related proteins in a two-step manner.

Zheng ZH1,2,3, Yang HY1,2, Gu L4, Peng XM5,6.
Virus genes.Virus Genes.2016 Apr 22. [Epub ahead of print]
The cellular proteasomes presumably inhibit the replication of hepatitis B virus (HBV) due to degradation of the viral core protein (HBcAg). Common proteasome inhibitors, however, either enhance or inhibit HBV replication. In this study, the exact degradation process of HBcAg and its influences on H
PMID 27105855

Japanese Journal

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NAID 130002098068

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肝臓 50(6), 238-243, 2009-05-25
C型慢性肝炎に対するインターフェロン投与で著効になったにもかかわらず13年後に発癌し，しかもその肝組織中のHCV RNAプラス鎖，マイナス鎖を調べた結果，いずれも検出されなかった1例を経験したので報告する．症例は75歳の男性で1994年よりC型慢性肝炎で当院に通院していた．肝生検ではF1A1であった.HCVはgenotypeIIa.IFNα2aを24週間投与し著効になった．以後半年に一回，採血と …
NAID 10024805160

HBcAg-pulsed dendritic cell vaccine induces Th1 polarization and production of hepatitis B virus-specific cytotoxic T lymphocytes

CHEN Weiwei,SHI Ming,SHI Feng,MAO Yuanli,TANG Zirong,ZHANG Bin,ZHANG Hui,CHEN Liangen,CHEN Liming,XIN Shaojie,WANG Fu-sheng
Hepatology research : the official journal of the Japan Society of Hepatology 39(4), 355-365, 2009-04-01
NAID 10025325364

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