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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/02 21:32:37」(JST)

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GTPgammaS (GTPγS, guanosine 5'-O-[gamma-thio]triphosphate) is a nonhydrolyzable (although in some cases such as with dynamin it is slowly hydrolyzable) G-protein-activating analog of guanosine triphosphate (GTP). It has many physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes. Its 35GS labelled radioligand [³⁵S]GTPgammaS is used in autoradiography and G-protein binding studies.

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English Journal

Alterations in the striatal dopamine system during intravenous methamphetamine exposure: Effects of contingent and noncontingent administration.

Laćan G, Hadamitzky M, Kuczenski R, Melega WP.SourceDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Synapse (New York, N.Y.).Synapse.2013 Aug;67(8):476-88. doi: 10.1002/syn.21654. Epub 2013 Mar 19.
The continuing spread of methamphetamine (METH) abuse has stimulated research aimed at understanding consequences of its prolonged exposure. Alterations in nigrostriatal dopamine (DA) system parameters have been characterized in experimental studies after discontinuation of long-term METH but fewer
PMID 23417852

Scission of COPI and COPII Vesicles Is Independent of GTP Hydrolysis.

Adolf F, Herrmann A, Hellwig A, Beck R, Brügger B, Wieland FT.SourceHeidelberg University Biochemistry Center (BZH), University of Heidelberg, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany.
Traffic (Copenhagen, Denmark).Traffic.2013 Aug;14(8):922-32. doi: 10.1111/tra.12084. Epub 2013 Jun 10.
Intracellular transport and maintenance of the endomembrane system in eukaryotes depends on formation and fusion of vesicular carriers. A seeming discrepancy exists in the literature about the basic mechanism in the scission of transport vesicles that depend on GTP-binding proteins. Some reports des
PMID 23691917

Multiple conformations of 5-HT2A and 5-HT 2C receptors in rat brain: an autoradiographic study with [125I](±)DOI.

López-Giménez JF, Vilaró MT, Palacios JM, Mengod G.SourceInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC-CSIC, UC), Santander, Spain.
Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale.Exp Brain Res.2013 Jul 18. [Epub ahead of print]
Earlier autoradiographic studies with the 5-HT2 receptor agonist [125I](±)DOI in human brain showed unexpected biphasic competition curves for various 5-HT2A antagonists. We have performed similar studies in rat brain regions with selective 5-HT2A (M100907) and 5-HT2C (SB242084) antagonists togethe
PMID 23864045

Japanese Journal

中脳上丘に存在するヒスタミンH_3受容体と視機能の関与

柴智子,谷内一彦,脇舛耕一,三戸秀哲,真野俊治,井出醇,西田幸二
眼薬理 = Japanese journal of ocular pharmacology 23(1), 76-78, 2009-08-31
NAID 10027119528

Activation of spinal cannabinoid 1 receptors inhibits C-fibre driven hyperexcitable neuronal responses and increases [35S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats

DREW LJ
Eur J Neurosci. 12, 2079-2086, 2000
NAID 30014382047

The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca^<2+>-sensitization of smooth muscle

X Fu
FEBS Lett 440, 183-187, 1998
NAID 80010704390

Related Pictures

GTPgammaS Exporter, GTPgammaS Manufacturer Guanosine 5'-thiotriphosphate (GTPgammaS EDA-GTPgammaS-dye Glutamate receptors and learning and FIGURE 6 | Specialized lipid signalling 35S GTP binding assays-ARTICLE

★リンクテーブル★

リンク元	「GTP-gamma-S」「Guanosine 5'-O-(3-Thiotriphosphate)」

「GTP-gamma-S」

GTPgammaS
	IUPAC name [(2S,3R,4S,5S)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydroxyphosphinothioyl hydrogen phosphate
Identifiers
CAS number	37589-80-3
PubChem	37792
Jmol-3D images	Image 1
	SMILES S=P(O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n1cnc2c1NC(=N/C2=O)\N)[C@H](O)[C@@H]3O ;
	InChI InChI=1/C10H16N5O13P3S/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1; Key: XOFLBQFBSOEHOG-UUOKFMHZBU ;
Properties
Molecular formula	C10H16N5O13P3S
Molar mass	539.25 g mol−1
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references