関: See Glycosphingolipids

English Journal

Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic.

Klokk TI1,2, Kavaliauskiene S3,4,5, Sandvig K3,4,5.
Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2016 Mar;73(6):1301-16. doi: 10.1007/s00018-015-2049-1. Epub 2015 Sep 25.
Glycosphingolipids (GSLs) are predominantly found in the outer leaflet of the plasma membrane, where they play a role in important processes such as cell adhesion, migration and signaling. However, by which mechanisms GSLs regulate these processes remains elusive. In this study, we therefore took ad
PMID 26407609

Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies.

Ando R1, Tokuda N1, Yamamoto T2, Ikeda K3, Hashimoto N1, Taguchi R4, Fan X1, Furukawa K1,4, Niimura Y5, Suzuki A6, Goto M2, Furukawa K7,8.
Glycoconjugate journal.Glycoconj J.2016 Feb 16. [Epub ahead of print]
In this study, we immunized Gb3/CD77 synthase gene (A4galt) knockout (KO) mice with glycosphingolipids (GSLs) extracted from 3 renal cell cancer (RCC) cell lines to raise monoclonal antibodies (mAbs) reactive with globo-series GSLs specifically expressed in RCCs. Although a number of mAbs reactive w
PMID 26883028

Characterization of glycosphingolipid epimers by radical-directed dissociation mass spectrometry.

Pham HT1, Julian RR1.
The Analyst.Analyst.2016 Feb 8;141(4):1273-8. doi: 10.1039/c5an02383a.
Glycosphingolipids (GSLs) are important metabolic regulators that control critical cellular functions and are found in all cell membranes. GSL epimers which only differ in the orientation of a single OH group are indicators for different lysosomal storage diseases. In this study, we investigate stru
PMID 26800360

Japanese Journal

A world of sphingolipids and glycolipids in the brain —Novel functions of simple lipids modified with glucose—

HIRABAYASHI Yoshio
Proceedings of the Japan Academy, Series B 88(4), 129-143, 2012
… Glycosphingolipids (GSLs) are present on cell surface membranes and are particularly abundant in the brain. … Since over 300–400 GSLs are synthesized from glucosylceramide (GlcCer), GlcCer is believed to only serve as the source of most GSLs, including sialic acid-containing GSLs or gangliosides, in the brain. …
NAID 130001924741

ガングリオシドGM3合成の制御機構

上村聡志
薬学雑誌 132(8), 895-901, 2012
… Glycosphingolipids (GSLs) exist in the outer leaflet of the plasma membrane, where they form lipid microdomains that function as platforms for the regulation of trans-membrane signal transduction. … In mammals, complex GSLs differing in the number and/or type of sugar species are produced in a cell-type specific manner, and the variety of glycan structures in GSLs are believed to determine specific cell functions. …
NAID 130001888707

Dengue virus receptor

HIDARI Kazuya I. P. J.,SUZUKI Takashi
Tropical medicine and health 39(4), 37-43, 2011-12-01
… There are also several lines of evidence for receptor molecules such as GSLs, proteins with chaperone activity, laminin-binding proteins, and other uncharacterized proteins in mosquito cells and organs. …
NAID 10030727280

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