関: See G protein-coupled receptors

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1. 血管作動性腸管ポリペプチド vasoactive intestinal polypeptide
2. ペプチドホルモンのシグナル伝達および調節 peptide hormone signal transduction and regulation
3. セクレチン secretin
4. 原発性両側副腎皮質大結節性過形成によるクッシング症候群 cushings syndrome due to primary bilateral macronodular adrenal hyperplasia
5. 健常者および疾患を有する患者における消化管ホルモンの概要 overview of gastrointestinal peptides in health and disease

English Journal

N-linked Glycosylation on the N-terminus of the dopamine D2 and D3 receptors determines receptor association with specific microdomains in the plasma membrane.

Min C1, Zheng M1, Zhang X1, Guo S1, Kwon KJ2, Shin CY2, Kim HS3, Cheon SH4, Kim KM5.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jan;1853(1):41-51. doi: 10.1016/j.bbamcr.2014.09.024. Epub 2014 Oct 5.
Numerous G protein-coupled receptors (GPCRs) are glycosylated at extracellular regions. The regulatory roles of glycosylation on receptor function vary across receptor types. In this study, we used the dopamine D2 and D3 receptors as an experimental model to understand the underlying principles gove
PMID 25289757

Molecular interactions between general anesthetics and the 5HT2B receptor.

Matsunaga F1, Gao L, Huang XP, Saven JG, Roth BL, Liu R.
Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2015 Jan;33(1):211-8. doi: 10.1080/07391102.2013.869483. Epub 2013 Dec 23.
BACKGROUND: Serotonin modulates many processes through a family of seven serotonin receptors. However, no studies have screened for interactions between general anesthetics currently in clinical use and serotonergic G-protein-coupled receptors (GPCRs). Given that both intravenous and inhalational an
PMID 24365264

Trafficking and function of GPCRs in the endosomal compartment.

Calebiro D1, Godbole A, Lyga S, Lohse MJ.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2015;1234:197-211. doi: 10.1007/978-1-4939-1755-6_16.
New methods based on fluorescently labeled agonists, genetically encoded fluorescent sensors, and advanced microscopy techniques, such as fluorescence resonance energy transfer (FRET) and highly inclined thin illumination (HILO), allow direct monitoring of signaling, internalization, and intracellul
PMID 25304358

Japanese Journal

Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

Etori Keishi,Saito Yuki C.,Tsujino Natsuko,Sakurai Takeshi
Frontiers in Neuroscience 2014(8), 8, 2014-01
… Orexins (also known as hypocretins) play critical roles in the regulation of sleep/wakefulness states by activating two G-protein coupled receptors (GPCRs), orexin 1 (OX1R) and orexin 2 receptors (OX2R). …
NAID 120005452005

Design, synthesis and biological evaluation of naphthalimidebased fluorescent probes for α1-adrenergic receptors

Zhang Wei,Chen Laizhong,Ma Zhao,Du Lupei,Li Minyong
Drug Discoveries & Therapeutics 8(1), 11-17, 2014
… α1-Adrenergic receptors (α1-ARs), as one of the most important members of G protein-coupled receptors (GPCRs), can mediate lots of physiological responses of the sympathetic nervous system. …
NAID 130003397394

新規GPCR活性化検出法を利用したオーファン受容体のリガンドの同定

井上飛鳥,青木淳賢
生化学 85(11), 1029-1033, 2013-11
NAID 40019893957

Related Pictures

GPCRs简介 GPCRs percent of therapeutic drugs target gpcrs GPCRs GPCRs play key roles in a large number of Receptors (GPCRs) | www.bioquicknews.com Representative Structural Coverage of the Protein–Coupled Receptors (GPCRs)