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1. 急性輸血反応が疑われる患者に対するアプローチapproach to the patient with a suspected acute transfusion reaction [show details]
… possible to minimize the impact of the reaction. This topic describes our approach to determining the nature of a suspected acute reaction (ie, the type of reaction and likely causes) following transfusion …
2. 複数の分子を標的にするチロシンキナーゼ阻害薬により発現する手足皮膚反応hand foot skin reaction induced by multitargeted tyrosine kinase inhibitors [show details]
…after two weeks of treatment. If the reaction has not improved or has worsened, patients are treated in the same way as those with grade 3 rash . For grade 2 reaction that does not respond to treatment …
3. 造影剤投与後の急性反応の診断と治療diagnosis and treatment of an acute reaction to a radiologic contrast agent [show details]
… previous severe reaction to the same type of contrast agent . Patients with a history of an allergic-like reaction to an iodinated contrast agent are not at increased risk for a reaction to a gadolinium-based …
4. アバカビル過敏反応abacavir hypersensitivity reaction [show details]
…potential risk factor for certain drug reactions has only become well defined over the past few years. Associations have been drawn between severe hypersensitivity reactions to particular drugs and specific …
5. 戦闘ストレス障害combat and operational stress reaction [show details]
…operational stress. Reactions to these stressors can affect individuals in a number of domains: Physiologic, emotional, cognitive, and behavioral. Combat and operational stress reaction (COSR; or combat …

English Journal

JAK/STAT Blockade Alters Synovial Bioenergetics, Mitochondrial Function, and Proinflammatory Mediators in Rheumatoid Arthritis.

McGarry T, Orr C, Wade S, Biniecka M, Wade S, Gallagher L, Low C, Veale DJ, Fearon U.
Arthritis & rheumatology (Hoboken, N.J.). 2018 Dec;70(12)1959-1970.
To examine the effects of tofacitinib on metabolic activity, mitochondrial function, and proinflammatory mechanisms in rheumatoid arthritis (RA). Ex vivo RA synovial explants and primary RA synovial fibroblasts (RASFs) were cultured with 1 μM tofacitinib. RASF bioenergetics were assessed using an X
PMID 29790294

Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia.

Brzeszczyńska J, Meyer A, McGregor R, Schilb A, Degen S, Tadini V, Johns N, Langen R, Schols A, Glass DJ, Roubenoff R, Ross JA, Fearon KCH, Greig CA, Jacobi C.
Journal of cachexia, sarcopenia and muscle. 2018 02;9(1)93-105.
Sarcopenia is defined as the age-related loss of skeletal muscle mass and function. While all humans lose muscle with age, 2-5% of elderly adults develop functional consequences (disabilities). The aim of this study was to investigate muscle myogenesis in healthy elderly adults, with or without sarc
PMID 29214748

Effects of Altering Trunk Position during Landings on Patellar Tendon Force and Pain.

Scattone Silva R, Purdam CR, Fearon AM, Spratford WA, Kenneally-Dabrowski C, Preston P, Serrão FV, Gaida JE.
Medicine and science in sports and exercise. 2017 Dec;49(12)2517-2527.
This study aimed to verify the immediate effects of altering sagittal plane trunk position during jump landings on lower limb biomechanics, patellar tendon force, and pain of athletes with and without patellar tendinopathy. Twenty-one elite male athletes were categorized into three groups: athletes
PMID 28704344

Japanese Journal

ヒダントイン化合物のJaffé 反応とN-カルバミル化合物の分子内脱水閉環反応の研究

高橋十郎,幡山文一,亀野靖郎
臨床化学 9(3), 333-337, 1980
… reaction and Fearon reaction. … reaction were compared. … The Jaffe reaction of 1-methyl hydantoin proceededs more sluggishly than that of creatinine.<Br>3. …
NAID 130003356948