関: fibroblast growth factor-23

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the 6th letter of the Roman alphabet (同)f

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/02 02:14:26」(JST)

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Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene.^[1] FGF23 is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism.^[2]

Function

Clinical significance

FGF23 is located on chromosome 12 and is composed of three exons. Mutations in FGF23 that render the protein resistant to proteolytic cleavage leads to increased activity of FGF23 and the renal phosphate loss found in the human disease autosomal dominant hypophosphatemic rickets. FGF23 is also overproduced by some types of tumors, such as the benign mesenchymal neoplasm Phosphaturic mesenchymal tumor causing tumor-induced osteomalacia, a paraneoplastic syndrome.^[3] Loss of FGF23 activity is thought to lead to increased phosphate levels and the clinical syndrome of familial tumor calcinosis. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets.^[4] Prior to discovery in 2000, it was hypothesized that a protein existed which performed the function of FGF23. This putative protein was known as phosphatonin.

References

^ Yamashita T, Yoshioka M, Itoh N (October 2000). "Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain". Biochem. Biophys. Res. Commun. 277 (2): 494–8. doi:10.1006/bbrc.2000.3696. PMID 11032749.
^ Fukumoto S (2008). "Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23". Intern. Med. 47 (5): 337–43. doi:10.2169/internalmedicine.47.0730. PMID 18310961.
^ Zadik Y, Nitzan DW (October 2011). "Tumor induced osteomalacia: A forgotten paraneoplastic syndrome?". Oral Oncol 48 (2): e9–10. doi:10.1016/j.oraloncology.2011.09.011. PMID 21985764.
^ "Entrez Gene: FGF23 fibroblast growth factor 23". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8074.

UpToDate Contents

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1. 腎性骨異栄養症の病因 pathogenesis of renal osteodystrophy
2. 低リン血症の原因 causes of hypophosphatemia
3. 高リン血症の原因および治療 causes and treatment of hyperphosphatemia
4. 遺伝性低リン血症性くる病と腫瘍誘発性骨軟化症 hereditary hypophosphatemic rickets and tumor induced osteomalacia
5. ビタミンDの代謝 metabolism of vitamin d

English Journal

Resistance to thyroid hormone due to mutations in the THRB gene impairs bone mass and affects calcium and phosphorus homeostasis.

Cardoso LF1, de Paula FJ1, Maciel LM2.
Bone.Bone.2014 Oct;67:222-7. doi: 10.1016/j.bone.2014.07.017. Epub 2014 Jul 23.
CONTEXT: Resistance to thyroid hormone (RTH) is an inherited syndrome of reduced tissue responsiveness to thyroid hormone, which is usually due to mutations in the thyroid hormone receptor β gene (THRB). Few studies have been conducted to investigate bone and mineral metabolism in RTH.OBJECTIVE: Th
PMID 25063548

Impact of hemodialysis, left ventricular mass and FGF-23 on myocardial mechanics in end-stage renal disease: a three-dimensional speckle tracking study.

Kovács A1, Tapolyai M, Celeng C, Gara E, Faludi M, Berta K, Apor A, Nagy A, Tislér A, Merkely B.
The international journal of cardiovascular imaging.Int J Cardiovasc Imaging.2014 Oct;30(7):1331-7. doi: 10.1007/s10554-014-0480-2. Epub 2014 Jul 8.
Left ventricular (LV) hypertrophy and one of its inducers, the fibroblast growth factor-23 (FGF-23) were found to be associated with unfavourable outcome in end-stage renal disease (ESRD) patients. We sought to investigate the influence of hemodialysis (HD), increased LV mass and FGF-23 on LV mechan
PMID 25001896

Eldecalcitol replaces endogenous calcitriol but does not fully compensate for its action in vivo.

Saito H1, Harada S2.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2014 Oct;144PA:189-196. doi: 10.1016/j.jsbmb.2013.11.013. Epub 2013 Nov 26.
Calcitriol (1α,25-dihydroxyvitamin D3, 1α,25(OH)2D3) is an essential hormone that works in cooperation with parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) to regulate calcium and phosphorus homeostasis. Previous in vivo studies in rats have shown that eldecalcitol, a vitamin D
PMID 24291401

Japanese Journal

骨血管相関におけるリン代謝の重要性 (第15回日本骨粗鬆症学会シンポジウム1 骨粗鬆症と動脈硬化の接点)

今西康雄,与田真貴,三木隆己 [他]
オステオポローシスジャパン : 日本骨粗鬆症学会雑誌 22(1), 15-18, 2014
NAID 40019986923

これからのカルシウム・リン代謝マーカー : 25OHD,FGF-23 (AYUMI 骨代謝マーカーUpdate : 研究と臨床)

今西康雄,稲葉雅章
医学のあゆみ 246(12), 1049-1053, 2013-09-21
NAID 40019789924

新着論文要約と解説 2型糖尿病患者は経口リン摂取に対するFGF23の反応が障害される : 動脈硬化の推定機序

中原健裕,倉林正彦
O.li.v.e. : osteo lipid vascular & endocrinology : 骨代謝と生活習慣病の連関 3(3), 165-168, 2013-08
NAID 40019794777

Related Pictures

Fgf 23 Fgf23 Klotho Fgf 23 Fgf 23 Mecanismo de acción del FGF-23. Fgf 23 Fgf 23

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関連記事	「FGF」「F」「FGFs」

「FGF」

Fibroblast growth factor 23
	; PDB rendering based on 2p39.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2P39
Identifiers
Symbols	FGF23; ADHR; HPDR2; HYPF; PHPTC
External IDs	OMIM: 605380 MGI: 1891427 HomoloGene: 10771 GeneCards: FGF23 Gene
Gene Ontology
Molecular function	• type 1 fibroblast growth factor receptor binding; • growth factor activity;
Cellular component	• extracellular region; • extracellular space;
Biological process	• phosphate-containing compound metabolic process; • insulin receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • regulation of phosphate transport; • positive regulation of vitamin D 24-hydroxylase activity; • cell differentiation; • negative regulation of bone mineralization; • cellular phosphate ion homeostasis; • vitamin D catabolic process; • negative regulation of osteoblast differentiation; • positive regulation of transcription, DNA-dependent; • negative regulation of hormone secretion; • phosphate ion homeostasis; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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